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Stock Market Waffles, Biotech Jumps Ahead Of Friday’s September Jobs Report – $INDP $INVO $LTRN $MRTX $NUVL $SHIP $SNY $TEVA Rise!

By John F. Heerdink, Jr.
Quote of the Day —  “If opportunity doesn’t knock, build a door.” – Milton Berle


Happy Thursday!

I hope all went as planned or even better than you could have expected on this fourth day of the week.

As for the stock market on Thursday, the major indices closed slightly in the red after dipping more significantly earlier in the session today ahead of tomorrow’s key macroeconomic job related reports. Thursday’s macroeconomic schedule produced the Weekly Initial Claims report that came in at 207k & the Weekly Continuing Claims clocked in at 1.664M. The August Trade Balance report came in at -$58.3B. Oil prices pulled back once again to close at $82.47/bbl, down 2.08. The 2-yr note closed at 5.03% down 6bps & the 10-yr note closed at 4.71%, down 3bps. The US Dollar Index backed off .42%, but remains unseasonably high at $106.35.  The CBOE Volatility Index (^VIX) closed at $18.49, down .48%.   

The 10-yr note yield was at 4.71% just before the release and jumped to 4.77% in the immediate aftermath. It settled the day at 4.71%, which is down three basis points from yesterday. The 2-yr note yield was at 5.02% just before 8:30 a.m. ET and jumped to 5.07% in response to the data, ultimately settling the session six basis points lower at 5.03%.

At the end of today’s session the Dow 30 closed at 33,119.57 (-.03%). The S&P 500 closed at 4,258.19 (-.13%) with 7 of the 11 sectors closing in the red with the real estate sector up .7%, the health care sector up .5%, the financials sector up .4%, & the information technology sector up .3% the four sectors to close in positive territory. The Nasdaq closed at 13,219.83 (-.12%), while Cathie Wood’s ARK Innovation ETF (ARKK) closing at $38.54, +.03%. The Magnificent Seven closed as follows:  Alphabet (GOOG) closing at $135.99, -.21%,  Amazon (AMZN) closing at $125.96, -.82%, Apple (AAPL) closing at $174.91, +.72%, Meta Platforms (META) closing at $304.79, -.26%, Microsoft (MSFT) closing at $319.36, +.13%, NVIDIA (NVDA) closing at $446.88, +1.47% & Tesla (TSLA) closing at $260.05, -.43% today.   

The Russell 2000 closed at 1,731.51 (+.14%). The microcaps also fell as the iShares Micro-Cap ETF (IWC) closed today at $97,87, +.67%.

The beaten down biotech stocks that make up the SPDR S&P Biotech ETF (XBI) rebounded nicely today and closed at $72,15, +3.25% after establishing a new 52-wk low $69.09 this week. The iShares Biotechnology ETF (IBB) closed at $121.78, +1.33%. The 52-range is $116.05 – $138.74. 

The iShares U.S. Healthcare ETF (IYH) closed at $269.59, +.65%.

Banks stocks overall jumped sharply today as the SPDR S&P Regional Banking ETF (KRE) closed at $40.98, +1.66% and the SPDR S&P Bank ETF (KBE) rose 1.57% closing at $36.18.

Around the crypto and precious metals’ tree, Bitcoin (BTC) traded to $27,448.09, -.90% over the last 24 hours at the time of this writing. Gold prices closed at $1,823, -$5/oz. & silver closed at $20.99, -$.18/oz. on the day.  


FURTHER AFIELD 

Shares of Nuvalent, Inc. (Nasdaq: NUVL) closed at $62.41, +8.52% after yesterday’s +35% gain). Nuvalent, a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer,  announced yesterday preliminary data from the Phase 1 dose-escalation portion of its ongoing ALKOVE-1 Phase 1/2 clinical trial of NVL-655 for patients with advanced ALK-positive non-small cell lung cancer (NSCLC) and other solid tumors as reported in an abstract accepted for presentation at the 35th AACR-NCI-EORTC (ANE) Symposium in Boston, Massachusetts. Updated preliminary data will be presented at the conference and during a live webcast and conference call with management on October 13th at 8:00am EDT. NVL-655 is a novel brain-penetrant ALK-selective tyrosine kinase inhibitor (TKI) created with the aim to simultaneously overcome the clinical challenges of emergent treatment resistance, brain metastases, and off-target central nervous system (CNS) adverse events associated with tropomyosin receptor kinase (TRK) inhibition that may limit the use of currently available ALK TKIs.

Shares of Mirati Therapeutics (MRTX), a commercial stage research and development biotechnology company whose mission is to discover, design and deliver breakthrough therapies to transform the lives of patients with cancer and their loved ones, jumped a cool 45.44% to close at $62.38 and with a market cap that has swelled to $4.36B. This move came in concert with a Bloomberg story that declared that Sanofi (SNY, $54.05, +.41%) is exploring and acquisition of Mirati. This news came after this week’s announcement that Sanofi and Teva Pharmaceuticals, a U.S. subsidiary of Teva Pharmaceutical Industries Ltd. (TEVA, +1.63%) are collaborating to co-develop and co-commercialize asset TEV ‘574, currently in Phase 2b clinical trials for the treatment of Ulcerative Colitis and Crohn’s Disease, two types of inflammatory bowel disease.



MEMES CENTRAL

Memes stock GameStop Corp. (GME) closed at $14.71, -1.08% as the shorts won their ongoing daily battle today. 

Shares of AMC, the largest movie exhibition company in the United States, the largest in Europe and the largest throughout the world with approximately 950 theaters and 10,500 screens across the globe, closed today at $8.30, -.48%.  


VP WATCHLIST UPDATES 


Lantern (LTRN), closed at $3.17, +1.28% & has moved up to $3.33, +5.05% in the aftermarket. Lantern is an Artificial Intelligence (AI) firm that is transforming the cost, pace, and timeline of oncology drug discovery and development and specifically is developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs.

On Oct. 3, Lantern announced that in vivo data highlighting the enhanced efficacy of Lantern’s drug candidate LP-184 in glioblastoma (GBM) were published in Clinical Cancer Research, a journal of the American Association for Cancer Research. LP-184 is a unique small molecule with low nanomolar activity and favorable CNS penetration. LP-184 utilizes its powerful mechanism of action, known as synthetic lethality, to exploit common vulnerabilities in solid tumor and CNS cancers with DNA damage repair (DDR) deficiencies. In addition, Lantern’s AI platform, RADR®, has highlighted overlapping gene dependency profiles between GBM tumorigenesis and sensitivity to LP-184, such as EGFR activation pathways. The article, entitled “Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma” can be accessed here.

 

Panna Sharma is the President, CEO, and Board Member of Lantern Pharma Inc.

“The data highlighted in Clinical Cancer Research solidify LP-184 as a promising therapeutic for GBM, with LP-184 having inhibited the viability and growth of multiple GBM models including temozolomide-resistant and MGMT-expressing cells,” stated Panna Sharma, Lantern’s President and CEO.

“The rapid advancement of LP-184 into a first-in-human Phase 1 trial provides strong validation of the power of our AI-enabled approach to drug development. This approach is about more than just developing new treatments, it’s about making them more targeted, more effective, and ultimately doing all of this more efficiently. This publication demonstrates our ability to deliver on these aspirations and introduce new therapeutic programs in areas where there is significant unmet patient need.”



On September 25, Lantern announced the dosing of the first patient in the Phase 1 clinical trial evaluating Lantern’s investigational new drug LP-184 in patients with advanced solid tumors. LP-184 is being studied in a first-in-human Phase 1 clinical trial, having been developed with guidance from Lantern’s AI Platform, RADR®, as a potential therapy for a wide range of advanced solid tumors. LP-184 is one of two molecules in Lantern’s synthetic-lethal franchise that has been shown to have anti-cancer activity in tumors with DNA damage repair deficiency. Lantern estimates that LP-184 has a global aggregate market potential of approximately $11-13 billion, consisting of $6-7 billion for solid tumors and $5-6 billion for CNS cancers. To learn more click here.

On September 18, Lantern announced that the United States Food and Drug Administration (FDA) has cleared the investigational new drug (IND) application for LP-284. LP-284 is being developed for the treatment of relapsed or refractory non-Hodgkin’s lymphoma (NHL), including mantle cell lymphoma (MCL) and double hit lymphoma (DHL) and other high-grade B-cell lymphomas (HGBL). Lantern expects to commence enrollment of patients for the first-in-human Phase 1 trial for LP-284 during the fourth quarter of 2023. Lantern estimates that LP-284 can have the potential to improve outcomes for 40,000 to 80,000 patients with blood cancers annually, with a global annual market potential of $4 Billion USD.


On September 8, Lantern’s Chief Executive Officer, Panna Sharma, delivered a presentation titled “How Artificial Intelligence Is Crushing Drug Discovery Times & Costs In Cancer” at a Tribe Public CEO Presentation & Q&A Event. The Event video is now published at the Tribe Public YouTube Channel that you may view now by clicking here.

On August 31, Lantern announced that it will present positive data highlighting the anti-tumor potency of its drug candidate LP-284 for non-Hodgkin’s lymphoma (NHL) at the Society of Hematologic Oncology (SOHO) Eleventh Annual Meeting occurring on Sept. 6 – 9, 2023, at the George R. Brown Convention Center in Houston, Texas. LP-284 is a small molecule with a synthetically lethal mechanism of action that preferentially damages cancer cells.. Lantern is developing LP-284 for the treatment of relapsed or refractory NHL, including Mantle Cell Lymphoma and Double Hit Lymphomas. Lantern expects to initiate Phase 1 clinical trials for LP-284 during Q4 of 2023. Lantern’s LP-284 program has been accelerated and de-risked using AI insights and biological modeling powered by RADR®. Lantern has been able to advance LP-284 from initial RADR® insights regarding anti-cancer activity and potential mechanisms of action in hematological cancers, to selection of specific subtypes of lymphomas with superior response, to late-stage IND enabling studies, and initial design of first in human clinical trials in less than two years.

Details of the poster presentation are listed below and can be found on the SOHO website. A full version of the poster will be available on Lantern’s website on September 11, 2023.

Title: LP-284 – Targeting Homologous Recombination Deficiencies in B-Cell Non-Hodgkin’s Lymphomas with the Novel Anti-Tumor Small Molecule LP-284
Date and Time: September 6, 2023, 6:00pm CT
Poster Number: ABCL-180
Presenter: Jianli Zhou, Ph.D., Lantern Pharma

On August 28, Lantern announced a substantial increase in the power and capabilities of RADR® focused on improving the drug development process for immune checkpoint inhibitors (ICIs). These capabilities are expected to address the multiple challenges facing the increased usage of ICIs in cancer therapy. Since gaining regulatory approval in 2011, ICIs have improved the lives of tens of thousands of cancer patients as either monotherapies, and more recently, in combination regimens with other therapies. The success of ICIs has resulted in multiple competing ICI molecules, often from the same class, in overlapping cancer indications. Additionally, recent clinical trial failures reveal headwinds to the desired expansion of ICIs for a broader range of cancers and patient groups. Currently, there are over 5,200 ongoing clinical trials involving ICIs, many of these lacking adequate biomarker strategies or guidance from AI enabled approaches to optimize the selection of patient responder populations. In a recent study presented at the 2023 ASCO meeting, RADR’s® algorithms demonstrated an 88% accuracy rate in predicting which melanoma (skin cancer) patients exhibiting resistance to anti-PD1 therapy will respond to Elraglusib, a GSK-3ϐ inhibitor being developed by Actuate Therapeutics, which previously entered into a multi-year research and development collaboration with Lantern Pharma to leverage the RADR® platform. The continued growth of ICIs, especially the approval of new ICIs, will be predicated on: 1) efficiently identifying new biomarker or molecular signatures for optimal patient selection, stratification, and management, and 2) rapidly developing combination regimens that overcome treatment challenges facing current and emerging solid and hematological cancer indications. Lantern’s latest RADR® AI developments will focus on addressing these challenges by building automated and highly scalable computational analytics to generate clinically relevant tumor-specific and tumor-agnostic molecular signatures to guide the identification and development of drug combinations that can prolong ICI durability of response and improve patient survival. These developments will leverage RADR® to uncover molecular drivers of response and resistance influencing ICI treatment outcomes by coupling pathway and network-based analytics with the simultaneous screening of millions of targets from complex clinical and biological data sets. This capability will be powered by tens of billions of new data points from immunotherapy and checkpoint inhibitor studies that Lantern has begun to add to its RADR® platform.

Lantern plans to deploy its new RADR® ICI predictive module with biopharma partners and to identify potential combinatorial strategies for LP-184 and LP-284, the first of Lantern’s drug candidates developed internally with the assistance of the RADR® AI platform. The ICI market is projected to reach $67.8 billion in annual sales by 2025, according to GlobalData, with future growth dependent on approvals from precision-based approaches guiding the development and positioning of new combination therapies.

On August 14, Lantern announced that it has received a notice of allowance from the United States Patent and Trademark Office (USPTO) covering a method of treatment for Atypical Teratoid Rhabdoid Tumor (ATRT) using LP-184, an aggressive and rapidly growing form of cancer of the central nervous system (CNS). LP-184 is the first of Lantern’s drug candidates developed by leveraging Lantern’s AI and ML platform, RADR®, to advance to a first-in-human Phase 1 basket trial. Lantern has rapidly advanced the clinical development of LP-184, activated the initial clinical trial sites, and has begun screening patients. Indications for the LP-184 trial are anticipated to include relapsed/refractory advanced pancreatic cancer, glioblastoma (GBM), brain metastases (brain mets), and multiple other recurring, advanced solid tumors with DNA damage response deficiencies. The dosage and safety data obtained in the Phase 1 trial will be used to advance the CNS indications, including ATRT, for a future Phase 2 trial to be sponsored by Lantern’s wholly-owned subsidiary, Starlight Therapeutics Inc. Globally, the aggregate annual market potential of LP-184’s target indications is estimated to be approximately $10+ billion, consisting of $5+ billion for CNS cancers and $6+ billion for other solid tumors. The U.S. Food and Drug Administration (FDA) has previously granted LP-184 Rare Pediatric Disease Designation and Orphan Drug Designation (ODD) for the treatment of pediatric patients with ATRT. The FDA has also previously granted LP-184 ODD for the treatment of pancreatic cancer and for the treatment of malignant glioma, including GBM. A notice of allowance is issued after the USPTO determines that the prosecution on the merits of a patent has been completed and grants the patent upon payment of the patent issuance fee. Additional corresponding patent applications are pending in Europe, Japan, Canada, and Australia.



Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP) closed at $2.62, +2.34%  and in the aftermarket at $2.95.  Indaptus is a company with the ability to harness both the body’s innate and adaptive immune responses, believes that they are uniquely positioned to revolutionize the treatment of cancer and certain infectious diseases. Indaptus Therapeutics has evolved from more than a century of immunotherapy advances. The Company’s novel approach is based on the hypothesis that efficient activation of both innate and adaptive immune cells and pathways and associated anti-tumor and anti-viral immune responses will require a multi-targeted package of immune system-activating signals that can be administered safely intravenously (i.v.). Indaptus’ patented technology is composed of single strains of attenuated and killed, non-pathogenic, Gram-negative bacteria producing a multiple Toll-like receptor (TLR), Nucleotide oligomerization domain (Nod)-like receptor (NLR) and Stimulator of interferon genes (STING) agonist Decoy platform. The products are designed to have reduced i.v. toxicity, but largely uncompromised ability to prime or activate many of the cells and pathways of innate and adaptive immunity. Decoy products represent an antigen-agnostic technology that have produced single-agent activity against metastatic pancreatic and orthotopic colorectal carcinomas, single agent eradication of established antigen-expressing breast carcinoma, as well as combination-mediated eradication of established hepatocellular carcinomas and non-Hodgkin’s lymphomas in standard pre-clinical models, including syngeneic mouse tumors and human tumor xenografts.

In pre-clinical studies tumor eradication was observed with Decoy products in combination with anti-PD-1 checkpoint therapy, low-dose chemotherapy, a non-steroidal anti-inflammatory drug, or an approved, targeted antibody. Combination-based tumor eradication in pre-clinical models produced innate and adaptive immunological memory, involved activation of both innate and adaptive immune cells, and was associated with induction of innate and adaptive immune pathways in tumors after only one i.v. dose of Decoy product, with associated “cold” to “hot” tumor inflammation signature transition. IND-enabling, nonclinical toxicology studies demonstrated safe i.v. administration without sustained induction of hallmark biomarkers of cytokine release syndromes, possibly due to passive targeting to liver, spleen, and tumor, followed by rapid elimination of the product. Indaptus’ Decoy products have also produced significant single agent activity against chronic hepatitis B virus (HBV) and chronic human immunodeficiency virus (HIV) infections in pre-clinical models.


On Sept, 29, Tribe Public hosted a Webinar Presentation and Q&A Event titled “Immunotherapy Reimagined” Indaptus Therapeutics’ (NASDAQ: INDP) CEO, Jeffrey Meckler delivered a presentation & also addressed a 5-10 minute Q&A session at the end of the presentation. You may view it now by clicking here. 


On Sept. 19, Indaptus announced dosing of the first patient in the second cohort of patients to receive a single dose of Decoy20 in the INDP-D101 trial. This cohort dose is a dose reduction from the previous cohort based on the significant pharmacodynamic effect seen with the first cohort and anticipated optimal Decoy20 safety profile for both weekly dosing and combination approaches. Dr. Roger Waltzman, Indaptus’ Chief Medical Officer stated, “This cohort is important to the development of Decoy20 as it may provide sufficient data for us to move Decoy20 to a multi-dosing regimen. To date, we have seen positive signs of an immune response with an anticipated adverse effect profile, and we look forward to seeing whether this lower dose provides similar evidence of increased cytokines that can trigger both innate and adaptive immune responses.” Jeffrey Meckler, Chief Executive Officer stated,“We continue to be encouraged by the initial results of the first cohort and look forward to progressing into the multi-dosing regimen as soon as we have enough data. The study’s objectives are to assess the safety and tolerability of Decoy20, to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as well as to assess Decoy20 pharmacokinetics (PK), pharmacodynamics and clinical activity.  The Phase 1 study was initiated with a single dose escalation, which is planned to be followed by an expansion with continuous weekly administration of Decoy20. The study is enrolling patients with advanced/metastatic solid tumors, who have exhausted approved treatment options. More information can be found at www.clinicaltrials.gov.

On August 14, Indaptus announced financial results for the second quarter ended June 30, 2023 and provided a corporate update.


Jeffrey Meckler, CEO, Indaptus Therapuetics, Inc. (NASDAQ: INDP)

Jeffrey Meckler, Chief Executive Officer of Indaptus stated, “We have recently announced the completion of the first cohort of patients in our INDP-D101 trial evaluating Decoy20 for the treatment of solid tumors and receipt of authorization from the Safety Review Committee to advance into the second cohort. As previously announced, we are pleased to observe evidence of immune activation, along with short-lived adverse events consistent with Decoy20’s mechanism of action. We continue to analyze the data generated and anticipate that the data from the dose finding studies will guide the selection for the recommended Phase 2 dose for subsequent multi-dosing and combination studies, which are planned for 2024. An additional recent accomplishment is the appointment of industry veteran, Roger Waltzman, M.D., as our Chief Medical Officer. We anticipate benefiting from his expertise as we continue our Phase 1 trial and further develop the Decoy platform. In the meantime, we are prudently managing our cash position.”


Recent Corporate Highlights:

  • The Company announced the completion of the first cohort of its INDP-D101 trial and receipt of authorization from its Safety Review Committee to proceed into the second cohort of the Phase 1 trial.
  • A compound from the Company’s Decoy platform was presented in a poster titled, “A systemically administered killed bacteria-based multiple immune receptor agonist for pulsed anti-tumor immunotherapy,” at the American Association for Cancer Research Conference 2023. The poster highlighted that Decoy10 demonstrated 90% reduction of LPS-endotoxin activity and use of 100% killed, non-pathogenic bacteria.
  • The Company’s Chief Scientific Officer, Michael Newman, Ph.D., was named Chair for two of the three days of the 4th STING & TLR-Targeting Therapies Summit held in Boston from May 9 to 11, where he was also a featured speaker.
  • The Company received patent allowances for its Decoy immunotherapy platform in Brazil and India. The Indian patent allowance brought the number of countries in which the Company holds patent protection to 32.
  • Roger Waltzman, M.D. was appointed the Chief Medical Officer of Indaptus, effective August 7, 2023.


Learn more about Indaptus Therapeutics (NASDAQ: INDP) at the VP Watchlist page by clicking here.


 

INVO Bioscience, Inc. (NASDAQ: INVO, $.7802, +4.30%) is a healthcare services fertility company focused on expanding access to advanced treatment worldwide with its INVOcell® medical device and the intravaginal culture (“IVC”) procedure it enables. On Aug. 14, INVO announced financial results for the second quarter ended June 30, 2023 and provided a business update. Q2 2023 Financial Highlights (all metrics compared to Q2 2022 unless otherwise noted):

  • Revenue was $315,902, an increase of 116% compared to $146,135.
  • Clinic revenue increased 126% to $254,364, compared to $112,358. All reported clinic revenue is derived from the Company’s INVO Center in Atlanta, Georgia, which is consolidated in the Company’s financial statements.
  • Revenue from all clinics, inclusive of both those accounted for as consolidated and under the equity method, was $712,433, an increase of 145% compared to $290,517.
  • Recent Operational and Strategic Highlights
  • Acquired Wisconsin Fertility Institute (WFI), a profitable Madison-based fertility center that primarily offers conventional IVF procedures and generated approximately $5.4 million in revenue and approximately $1.7 million of net income in 2022.
  • Acquisition further accelerates INVO’s transition to a healthcare services company and provides an opportunity to advance IVC volume and the ability to secure a greater share of total fertility cycle revenue.
  • Implemented expense reductions as part of go-forward plan to focus on its healthcare service strategy and a near-term path to profitability.
  • Buildout of the Company’s new Tampa, Florida clinic – Tampa Fertility Institute, an INVO Center – is nearing completion.
  • Raised approximately $4.5 million in gross proceeds in a public offering of common stock and warrants. The Company used approximately $2.15 million of proceeds for the initial payment for the WFI acquisition.
  • Received 510(k) FDA clearance for expanded use of the INVOcell device.

Q2 2023 Financial Highlights (all metrics compared to Q2 2022 unless otherwise noted)

  • Revenue was $315,902, an increase of 116% compared to $146,135.

  • Clinic revenue increased 126% to $254,364, compared to $112,358. All reported clinic revenue is derived from the Company’s INVO Center in Atlanta, Georgia, which is consolidated in the Company’s financial statements.

  • Revenue from all clinics, inclusive of both those accounted for as consolidated and under the equity method, was $712,433, an increase of 145% compared to $290,517.

Recent Operational and Strategic Highlights

  • Acquired Wisconsin Fertility Institute (WFI), a profitable Madison-based fertility center that primarily offers conventional IVF procedures and generated approximately $5.4 million in revenue and approximately $1.7 million of net income in 2022.

  • Acquisition further accelerates INVO’s transition to a healthcare services company and provides an opportunity to advance IVC volume and the ability to secure a greater share of total fertility cycle revenue.

  • Implemented expense reductions as part of go-forward plan to focus on its healthcare service strategy and a near-term path to profitability.

  • Buildout of the Company’s new Tampa, Florida clinic – Tampa Fertility Institute, an INVO Center – is nearing completion.

  • Raised approximately $4.5 million in gross proceeds in a public offering of common stock and warrants. The Company used approximately $2.15 millionof proceeds for the initial payment for the WFI acquisition.

  • Received 510(k) FDA clearance for expanded use of the INVOcell device.

Management Commentary

“We believe we have successfully transformed INVO into a rapidly growing, innovative healthcare services company which allows us to help accelerate IVC volume and obtain a greater share of the total fertility cycle revenue. The closing of the WFI acquisition last week, coupled with the rapid 145% revenue growth in our existing INVO Center’s during this past quarter, should position our clinic operations to be cash flow positive in the third quarter of this year. Further, we have implemented a number of expense reductions as part of our go-forward plan to focus on our healthcare service strategy, which when coupled with the elimination of substantive costs associated with our successful 510(k) submission, should drive the business towards overall positive operating cash flow in 2024,” commented Steve Shum, CEO of INVO. 

 
 
 
 
Shares of Atossa Therapeutics (ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative medicines in areas of significant unmet medical need in oncology with a current focus on breast cancer and lung injury caused by cancer treatments, closed at $.7167, +.45%.
 
On Aug. 14, Atossa announced financial results for the quarter ended June 30, 2023, and provided an update on recent company developments highlighted by the following: Achieved significant enrollment milestones in three ongoing Phase 2 clinical trials, Broadened patent protection for proprietary (Z)-endoxifen, Strengthened management team with appointment of Greg Weaver as Chief Financial Officer, & Ended second quarter 2023 with $99.4 million of cash and cash equivalents.
 
Shares of ADT Inc. (ADT), the most trusted brand in smart home and small business security, closed at $6.41, +3.05%. On Oct. 2, GTCR, a leading private equity firm, announced that it has closed the acquisition of ADT’s commercial security, fire and life safety security businessfrom ADT Inc. (“ADT”, NYSE: ADT). Moving forward as a standalone organization, ADT Commercial will rebrand as Everon. GTCR will partner with former Protection1 executives Dan Bresingham and Tim Whall, along with other members of ADTC leadership, to acquire the Company, one of the leading national providers of electronic security and fire safety services to commercial enterprises and multi-site national accounts. Mr. Bresingham, former leader of ADT’s commercial security, fire and life safety business, will become Chief Executive Officer of Everon and Mr. Whall will serve as an active director on the Company’s Board.
 
Shares of Seanergy Maritime Holdings Corp. (SHIP), the only pure-play Capesize ship-owner publicly listed in the U.S. closed at $5.86, +3.35%. On Aug. 2, Seanergy announced its financial results for the second quarter and six months ended June 30, 2023.  They highlighted that Fleet Time Charter Equivalent (“TCE” 3) overperformance of Baltic Capesize Index (“BCI”) by 20% in 2Q23 & 1H23, a Quarterly cash dividend of $0.025 per share for Q2 2023 – total cash dividends of $1.325 per share or $23.9 million declared since March 2022,  a stock buyback of $1.6 million, or approximately 2% of its issued and outstanding shares – total repurchases of securities (common shares, convertible notes and warrants) of approximately $39.6 million since November 2021, an Agreement to acquire a 2011-built Newcastlemax dry bulk vessel through a 12-month bareboat charter with a purchase option, & $53.8 million in refinancings during the second quarter, on improved terms, adding $15.0 million of extra liquidity and removing any loan maturities until Q2 2025.
 

Economic Reports

On Monday, the September ISM Manufacturing PMO report confirmed another contraction for the 11th consecutive month as it came in at 49%. The Total construction spending report also confirmed .5% M/M rise in August & The Total private construction report also showed a .5% M/M increase. Lastly, the Total public construction report clocked in with a .6% M/M rise & now on Y/Y basis, total construction spending rose 7.4%.

On Tuesday, the Job Openings and Labor Turnover Survey report confirmed a rise in job openings.

On Wednesday, The ADP Employment Change Report confirmed private payrolls rose by 89k in September that was below expectations. The weekly MBA Mortgage Applications Index dropped by 6%as  purchase applications fell 6% & refinance applications dropped a cool 7%. The ISM Services PMI report came with lower at 53.6% in September & the Factory orders report showed a M/M 1.2% rise in August. The weekly EIA crude oil inventories report also confirmed a 2.22M barrel draw.

On Thursday, the Weekly Initial Claims report came in at 207k & the Weekly Continuing Claims clocked in at 1.664M. The August Trade Balance report came in at -$58.3B.

Investing & Inspiration

  1. “If opportunity doesn’t knock, build a door.” – Milton Berle
  2. “The greatest use of a life is to spend it on something that will outlast it.” – William James
  3. “Happiness is not something ready made. It comes from your own actions.” – Dalai Lama
  4. “Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.” – Thomas A. Edison
  5. “There are people who have money and people who are rich.” – Coco Chanel
  6. “The young man knows the rules, but the old man knows the exceptions.” – Oliver Wendell Holmes, Sr.
  7. “Let your mind alone, and see what happens.” – Virgil Thomson
  8. “I believe things cannot make themselves impossible.” – Stephen Hawking
  9. “There is nothing more uncommon than common sense.” – Frank Lloyd Wright 
  10. “To begin, begin.” – William Wordsworth
  11. “You can find peace amidst the storms that threaten you.” – Joseph B. Wirthlin
  12. “Everything that is made beautiful and fair and lovely is made for the eye of one who sees.” – Rumi
  13. “The secret of business is to know something that nobody else knows.” – Aristotle Onassis
  14. “Life is the art of drawing without an eraser.” – John W. Gardner
  15. “Learning never exhausts the mind.” – Leonardo da Vinci
  16. “Live as brave men; and if fortune is adverse, front its blows with brave hearts.” – Marcus Tullius Cicero
  17. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  18. “The end of labor is to gain leisure.” – Aristotle
  19. “Though we travel the world over to find the beautiful, we must carry it with us or we find it not.” – Ralph Waldo Emerson
  20. “Any sufficiently advanced technology is indistinguishable from magic.” – Arthur C. Clarke
  21. “Good questions outrank easy answers.” – Paul Samuelson
  22. “Experience is the teacher of all things.” – Julius Caesar
  23. To see things in the seed, that is genius.” – Lao Tzu
  24. “Lend yourself to others, but give yourself to yourself.” – Michel de Montaigne
  25. “People are not disturbed by things, but by the view they take of them.” – Epictetus
  26. “Knowledge comes, but wisdom lingers.” – Alfred Lord Tennyson
  27. “Hitch your wagon to a star.” – Ralph Waldo Emerson
  28. “If fear is cultivated it will become stronger, if faith is cultivated it will achieve mastery.” – John Paul Jones
  29. “Great minds discuss ideas; average minds discuss events; small minds discuss people.” –  Eleanor Roosevelt
  30. “Happiness is a direction, not a place.” – Sydney J. Harris
  31. “Don’t let making a living prevent you from making a life.” – John Wooden
  32. “The secret of your future is hidden in your daily routine.” – Mike Murdock
  33. “We boil at different degrees.” – Clint Eastwood
  34. “If we open a quarrel between past and present, we shall find that we have lost the future.” – Winston Churchill
  35. “Hope is patience with the lamp lit.” – Tertullian
  36. “All human wisdom is summed up in two words; wait and hope.” – Alexandre Dumas
  37. “Forgiveness is the key to action and freedom.” – Hannah Arendt
  38. “The unexamined life is not worth living.” – Socrates
  39. “I never think of the future – it comes soon enough.” – Albert Einstein
  40. “Today you are you! That is truer than true! There is no one alive who is you-er than you!” – Dr. Seuss
  41. “We live in a rainbow of chaos.” – Paul Cezanne
  42. “Real knowledge is to know the extent of one’s ignorance.” – Confucius
  43. “Better keep yourself clean and bright; you are the window through which you must see the world.” – George Bernard Shaw
  44. “Life consists not in holding good cards but in playing those you hold well.” – Josh Billings
  45. “The traveler sees what he sees, the tourist sees what he has come to see.” – Gilbert K. Chesterton
  46. “Goodness is the only investment that never fails.” – Henry David Thoreau
  47. “The return we reap from generous actions is not always evident.” – Francesco Guicciardini
  48. “Courage is knowing what not to fear.”– Plato
  49. “Freedom means the opportunity to be what we never thought we would be.” – Daniel J. Boorstin
  50. “Fishes live in the sea, as men do a-land; the great ones eat up the little ones.” – William Shakespeare
  51. “A man is what he thinks about all day long.” – Ralph Waldo Emerson
  52. “There are two ways of spreading light: to be the candle or the mirror that reflects it.” – Edith Wharton
  53. “We cannot live only for ourselves. A thousand fibers connect us with our fellow men.” – Herman Melville
  54. “Childhood is a short season” – Helen Hayes
  55. “Formula for success: rise early, work hard, strike oil.” – J. Paul Getty
  56. “The hardest arithmetic to master is that which enables us to count our blessings.” – Eric Hoffer
  57. “I fear not the man who has practiced 10,000 kicks once, but I fear the man who has practiced one kick 10,000 times.” – Bruce Lee
  58. “There are no shortcuts in evolution.” – Louis D. Brandeis
  59. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll
  60. “Our happiness depends on wisdom all the way.” – Sophocles
  61. “Life is the art of drawing without an eraser.” – John W. Gardner
  62. “Give light and people will find the way.” – Ella Baker
  63. “Without craftsmanship, inspiration is a mere reed shaken in the wind.” – Johannes Brahms
  64. “Either move or be moved.” – Ezra Pound
  65. “Time is but the stream I go a-fishing in.” – Henry David Thoreau
  66. “It’s easy to make a buck. It’s a lot tougher to make a difference.” – Tom Brokaw
  67. “If you can’t stand the heat, get out of the kitchen.” – Harry S Truman
  68. “Remember upon the conduct of each depends the fate of all.” – Alexander the Great
  69. “Silence is the sleep that nourishes wisdom.” – Francis Bacon
  70. “Have patience. All things are difficult before they become easy.” – Saadi
  71. “No man ever steps in the same river twice, for it’s not the same river and he’s not the same man.” – Heraclit
  72. “An effort made for the happiness of others lifts above ourselves.” – Lydia M. Child
  73. “It is amazing what you can accomplish if you do not care who gets the credit.” – Harry S Truman
  74. “If you do not think about your future, you cannot have one.” – John Galsworthy
  75. “Your own mind is a sacred enclosure into which nothing harmful can enter except by your permission.” – Arnold Bennett
  76. “There is always risk involved. You can’t be a capitalist only when there are investment profits but then a socialist when you experience losses.” – Cristina Kirchner
  77. “I hear, I know. I see, I remember. I do, I understand.” – Confucius
  78. “He has achieved success who has worked well, laughed often, and loved much.” – Elbert Hubbard
  79. “Nobody who ever gave his best regretted it.” – George Halas
  80. “We must not allow other people’s limited perceptions to define us.” – Virginia Satir
  81. “There is a wisdom of the head, and a wisdom of the heart.” – Charles Dickens
  82. “Perfection is the child of time.” – Joseph Hall
  83. “No matter what people tell you, words and ideas can change the world.” – Robin Williams
  84. “Find something you’re passionate about and keep tremendously interested in it.” – Julia Child
  85. “The glow of one warm thought is to me worth more than money.” – Thomas Jefferson
  86. “Between stimulus and response there is a space. In that space is our power to choose our response. In our response lies our growth and our freedom.” – Viktor E. Frankl
  87. “Progress lies not in enhancing what is, but in advancing toward what will be.” – Khalil Gibran
  88. “Cherish all your happy moments; they make a fine cushion for old age.” – Booth Tarkington
  89. “The most effective way to do it, is to do it.” – Amelia Earhart
  90. “If you’re going through hell, keep going.” – Winston Churchill
  91. “The only sure weapon against bad ideas is better ideas.” – Alfred Whitney Griswold
  92. “Words are, of course, the most powerful drug used by mankind.” – Rudyard Kipling
  93. “The more things change, the more they are the same.” – Alphonse Karr
  94. “Of all possessions a friend is the most precious.” – Herodotus
  95. “Everything has beauty, but not everyone sees it.” – Confucius
  96. “The man who is swimming against the stream knows the strength of it.” – Woodrow Wilson
  97. “Success is the sum of small efforts – repeated day in and day out.” – Robert Collier
  98. “You exist only in what you do.” – Federico Fellini
  99. “Most people have the will to win, few have the will to prepare to win.” – Bobby Knight
  100. “The true art of memory is the art of attention.” – Samuel Johnson
  101. The secret of happiness is something to do.” – John Burroughs
  102. “A will finds a way.” – Orison Swett Marden
  103. “To live is to think.” – Marcus Tullius Cicero
  104. “The sea hath fish for every man.” – William Camden
  105. “What is called genius is the abundance of life and health.” – Henry David Thoreau
  106. “Prosperity tries the fortunate, adversity the great.” – Rose Kennedy
  107. “No one can figure out your worth but you.” – Pearl Bailey
  108. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  109. “When one paints an ideal, one does not need to limit one’s imagination.” – Ellen Key
  110. “Perfection is attained by slow degrees; it requires the hand of time.” – Voltaire
  111. “Time passes irrevocably.” – Virgil
  112. “The world of reality has its limits; the world of imagination is boundless.” – Jean-Jacques Rousseau
  113. “The time you enjoy wasting is not wasted time.” – Bertrand Russell
  114. “Mastering others is strength. Mastering yourself is true power.” – Lao Tzu
  115. “You begin with the possibilities of the material.” – Robert Rauschenberg
  116. “If you live to be a hundred, I want to live to be a hundred minus one day so I never have to live without you.” – A. A. Milne
  117. “The only way to discover the limits of the possible is to go beyond them into the impossible.” – Arthur C. Clarke
  118. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha
  119. “Curiosity will conquer fear even more than bravery will.” – James Stephens
  120. “There are years that ask questions and years that answer.” – Zora Neale Hurston
  121. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller
  122. “Every failure is a step to success.” – William Whewell
  123. “If you aren’t fired with enthusiasm, you will be fired with enthusiasm.” – Vince Lombardi
  124. “Either you run the day or the day runs you.” – Jim Rohn
  125. “A computer once beat me at chess, but it was no match for me at kick boxing.” – Emo Philips
  126. “I attribute my success to this – I never gave or took any excuse.” – Florence Nightingale
  127. “I can’t change the direction of the wind, but I can adjust my sails to always reach my destination.” – Jimmy Dean
  128. “If you fell down yesterday, stand up today.” – H. G. Wells
  129. “The world breaks everyone, and afterward, some are strong at the broken places.” – Ernest Hemingway
  130. “The quality, not the longevity, of one’s life is what is important.” – Martin Luther King, Jr.
  131. “You can’t expect to hit the jackpot if you don’t put a few nickels in the machine.” – Flip Wilson
  132. “Put your heart, mind, and soul into even your smallest acts. This is the secret of success.” – Swami Sivananda
  133. “If the highest aim of a captain were to preserve his ship, he would keep it in port forever.” – Thomas Aquinas
  134. “The secret of your future is hidden in your daily routine.” – Mike Murdock
  135. “Happiness is not a matter of intensity but of balance, order, rhythm and harmony.” – Thomas Merton
  136. “Seek the lofty by reading, hearing and seeing great work at some moment every day.” – Thornton Wilder
  137. “Once you bring life into the world, you must protect it. We must protect it by changing the world.” – Elie Wiesel
  138. “Let us permit nature to have her way. She understands her business better than we do.” – Michel de Montaigne
  139. “Great minds have purposes; others have wishes.” – Washington Irving
  140. “The great thing about getting older is that you don’t lose all the other ages you’ve been.” – Madeleine L’Engle
  141. “If you’re alive, there’s a purpose for your life.” – Rick Warren
  142. “Dream in a pragmatic way.” – Aldous Huxley
  143. “The works must be conceived with fire in the soul but executed with clinical coolness.” – Joan Miro
  144. “Memories are the key not to the past, but to the future.” – Corrie Ten Boom
  145. “Great minds discuss ideas; average minds discuss events; small minds discuss people.” – Eleanor Roosevelt
  146. “Failure will never overtake me if my determination to succeed is strong enough.” – Og Mandino
  147. “I think about my work every minute of the day.” – Jeff Koons
  148. “I restore myself when I’m alone.” –  Marilyn Monroe
  149. “Success is peace of mind which is a direct result of self-satisfaction in knowing you did your best to become the best you are capable of becoming.” – John Wooden
  150. “Courage is found in unlikely places.” – J. R. R. Tolkien
  151. “The first wealth is health.” – Ralph Waldo Emerson
  152. “Courage is found in unlikely places.” – J. R. R. Tolkien
  153. “Do what you can, with what you have, where you are.” – Theodore Roosevelt
  154. “A good beginning makes a good end.” – Louis L’Amour
  155. “What you do today can improve all your tomorrows.” – Ralph Marston
  156. “One that would have the fruit must climb the tree.” – Thomas Fuller
  157. “Joy in looking and comprehending is nature’s most beautiful gift.” – Albert Einstein
  158. “The future belongs to those who believe in the beauty of their dreams.” – Eleanor Roosevelt
  159. “Never go to bed mad. Stay up and fight.” – Phyllis Diller
  160. “The undertaking of a new action brings new strength.” – Richard L. Evans
  161. “It’s kind of fun to do the impossible.” – Walt Disney
  162. “Real riches are the riches possessed inside.” – B. C. Forbes
  163. “Reject your sense of injury and the injury itself disappears.” – Marcus Aurelius
  164. “It is not enough to have a good mind; the main thing is to use it well.” – Rene Descartes
  165. “A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell
  166. “It takes an endless amount of history to make even a little tradition.” – Henry James”It’s not what you pay a man, but what he costs you that counts.” – Will Rogers
  167. “Halloween is not only about putting on a costume, but it’s about finding the imagination and costume within ourselves.” – Elvis Duran
  168. “Everything in the world may be endured except continual prosperity.” – Johann Wolfgang von Goethe
  169. “Where is all the knowledge we lost with information?” – T. S. Eliot
  170. “All I ask is the chance to prove that money can’t make me happy.” – Spike Milligan
  171. “Out of difficulties grow miracles.” – Jean de la Bruyere
  172. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
  173. “Time is money.” – Benjamin Franklin
  174. “I can, therefore I am.” – Simone Weil
  175. “Where there is no vision, there is no hope.” – George Washington Carver
  176. “Greatness is a road leading towards the unknown.” – Charles de Gaulle
  177. “Kind words do not cost much. Yet they accomplish much.” – Blaise Pascal
  178. “The world is round so that friendship may encircle it.” – Pierre Teilhard de Chardin
  179. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
  180. The greatest use of a life is to spend it on something that will outlast it.” – William James
  181. “Happiness is not something ready made. It comes from your own actions.” – Dalai Lama
  182. “If opportunity doesn’t knock, build a door.” – Milton Berle
  183. “I would define, in brief, the poetry of words as the rhythmical creation of Beauty.” – Edgar Allan Poe
  184. “There are people who have money and people who are rich.” – Coco Chanel
  185. “The young man knows the rules, but the old man knows the exceptions.” – Oliver Wendell Holmes, Sr.
  186. “The past always looks better than it was. It’s only pleasant because it isn’t here.” – Finley Peter Dunne
  187. “With the new day comes new strength and new thoughts.” – Eleanor Roosevelt
  188. “Give me the luxuries of life and I will willingly do without the necessities.” – Frank Lloyd Wright
  189. “To begin, begin.” – William Wordsworth
  190. “You can find peace amidst the storms that threaten you.” – Joseph B. Wirthlin
  191. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
  192. “Whenever you find yourself on the side of the majority, it is time to pause and reflect.” – Mark Twain
  193. “Adapt or perish, now as ever, is nature’s inexorable imperative.” – H. G. Wells
  194. “Won’t be long before we view gasoline cars the same way we view steam engines today.” – Elon Musk
  195. “The aim of life is to live, and to live means to be aware, joyously, drunkenly, serenely, divinely aware.” – Henry Miller
  196. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare“Opportunity is missed by most people because it is dressed in overalls and looks like work.” – Thomas A. Edison“Experience is one thing you can’t get for nothing.” – Oscar Wilde
  197. “Any sufficiently advanced technology is indistinguishable from magic.” – Arthur C. Clarke
  198. “Good questions outrank easy answers.” – Paul Samuelson
  199. “Thinking: the talking of the soul with itself.” – Plato
  200. “I don’t think of all the misery but of the beauty that still remains.” – Anne Frank
  201. “All money is a matter of belief.” – Adam Smith
  202. “People are not disturbed by things, but by the view they take of them.” – Epictetus
  203. “Uncertainty is seen to retard investment independently of considerations of risk or expected return.” – Ben Bernanke
  204. “I never called my work an ‘art’. It’s part of show business, the business of building entertainment.” – Walt Disney
  205. “Hitch your wagon to a star.” – Ralph Waldo Emerson
  206. “The greatest remedy for anger is delay.” – Lucius Annaeus Seneca
  207. “Great minds discuss ideas; average minds discuss events; small minds discuss people.” – Eleanor Roosevelt
  208. “Act as if what you do makes a difference. It does.” – William James
  209. “Success – keeping your mind awake and your desire asleep.” – Walter Scott
  210. “If I had to live my life again, I’d make the same mistakes, only sooner.” – Tallulah Bankhead
  211. “When one must, one can.” – Charlotte Whitton
  212. “Wealth consists not in having great possessions, but in having few wants.” – Epictetus
  213. “If we open a quarrel between past and present, we shall find that we have lost the future.” – Winston Churchill
  214. “Hope is patience with the lamp lit.” – Tertullian
  215. “A single sunbeam is enough to drive away many shadows.” – Francis of Assisi
  216. “With the past, I have nothing to do; nor with the future. I live now.” – Ralph Waldo Emerson
  217. “Laziness may appear attractive, but work gives satisfaction.” – Anne Frank
  218. “I never think of the future – it comes soon enough.” – Albert Einstein
  219. “Hope is but the dream of those who wake.” – Matthew Prior
  220. “The more sand that has escaped from the hourglass of our life, the clearer we should see through it.” – Jean Paul
  221. “Real knowledge is to know the extent of one’s ignorance.” – Confucius
  222. “Better keep yourself clean and bright; you are the window through which you must see the world.” – George Bernard Shaw
  223. “Nothing great in the world has ever been accomplished without passion.” – Georg Wilhelm Friedrich Hegel
  224. “History is a vast early warning system.” – Norman Cousins
  225. “We first make our habits, and then our habits make us.” – John Dryden
  226. “The traveler sees what he sees, the tourist sees what he has come to see.” – Gilbert K. Chesterton
  227. “Adventure is worthwhile.” – Aesop
  228. “We must build dikes of courage to hold back the flood of fear.” – Martin Luther King, Jr.
  229. “The return we reap from generous actions is not always evident.” – Francesco Guicciardini
  230. “Courage is knowing what not to fear.” – Plato
  231. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
  232. “Progress was all right. Only it went on too long.” – James Thurber
  233. “If you would know strength and patience, welcome the company of trees.” – Hal Borland
  234. “We aim above the mark to hit the mark.” – Ralph Waldo Emerson
  235. “Hope is being able to see that there is light despite all of the darkness.” – Desmond Tutu
  236. “Our chief want is someone who will inspire us to be what we know we could be.” – Ralph Waldo Emerson
  237. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
  238. “Great things are done when men and mountains meet.” – William Blake
  239. “The man who has no imagination has no wings.” – Muhammad Ali
  240. “Formula for success: rise early, work hard, strike oil.” – J. Paul Getty
  241. “Action is the foundational key to all success.” – Pablo Picasso
  242. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.” – Samuel Smiles
  243. “The backbone of surprise is fusing speed with secrecy.” – Carl von Clausewitz
  244. “There are no shortcuts in evolution.” – Louis D. Brandeis
  245. “I am fascinated by what is beautiful, strong, healthy, what is living. I seek harmony.” – Leni Riefenstahl
  246. “If one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours.” – Henry David Thoreau
  247. “Waste no more time arguing about what a good man should be. Be one.” – Marcus Aurelius
  248. “It is during our darkest moments that we must focus to see the light.” – Aristotle Onassis
  249. “Courage is fear holding on a minute longer.” – George S. Patton
  250. “You must be the change you wish to see in the world.” – Mahatma Gandhi
  251. “Don’t judge each day by the harvest you reap but by the seeds that you plant.” – Robert Louis Stevenson
  252. “It is in the character of very few men to honor without envy a friend who has prospered.” – Aeschylus
  253. “Life is a series of natural and spontaneous changes. Don’t resist them – that only creates sorrow. Let reality be reality. Let things flow naturally forward in whatever way they like.” – Lao Tzu
  254. “The more you praise and celebrate your life, the more there is in life to celebrate.” – Oprah Winfrey
  255. “Anything simple always interests me.” – David Hockney
  256. “He who angers you conquers you.” – Elizabeth Kenny
  257. “Concision in style, precision in thought, decision in life.” – Victor Hugo
  258. “The secret of genius is to carry the spirit of the child into old age, which means never losing your enthusiasm.” – Aldous Huxley
  259. “View health as an investment, not an expense.” – John Quelch

“The most effective way to do it, is to do it.” – Amelia Earhart
“Man needs his difficulties because they are necessary to enjoy success.” – A. P. J. Abdul Kalam
“Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha
“Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
“You must do the things you think you cannot do.”- Eleanor Roosevelt
“Success is dependent on effort.” – Sophocles
“Nobody who ever gave his best regretted it.” – George Halas
“Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
“And when I breathed, my breath was lightning.” – Black Elk
“Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
“You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
“If you want a guarantee, buy a toaster.” – Clint Eastwood
“We are an impossibility in an impossible universe.” – Ray Bradbury
“If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
“I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
“Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
“It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
“Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
Surprise is the greatest gift which life can grant us.” – Boris Pasternak
“Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran
“Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
“All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
“There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” – Colin Powell
“There is more to life than increasing its speed.” – Mahatma Gandhi
“Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
“Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
“Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
“In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
“Life is too short for long-term grudges.” – Elon Musk
“There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
“Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
“The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
“Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
“Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
“But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
“Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
“Let there be work, bread, water and salt for all.” – Nelson Mandela
“The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
“A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
“I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
“It is the fight alone that pleases us, not the victory.” – Blaise Pascal
“If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
“Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
“Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
“Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
“You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
“Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
“Delete the negative; accentuate the positive!” – Donna Karan
“It’s crazy how fast time flies and how things progress.” – Nathan Chen
“The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
“Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
“Everything has beauty, but not everyone sees it.” – Confucius
“A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
“Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
“A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
“The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
“Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
“I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
“Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
“But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
“Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
“Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
“No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
“Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
“Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
“Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
“If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
“Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
“The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
“There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
“There is little that can withstand a man who can conquer himself.” – Louis XIV
“In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
“A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
“The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
“Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese
“Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
“Never do anything against conscience even if the state demands it.”– Albert Einstein
“Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
“The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
“In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
“A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
“The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
“Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
“Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
“Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
“No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch
“Start where you are. Use what you have. Do what you can.”– Arthur Ashe
“The secret of getting ahead is getting started.” – Mark Twain
“The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe

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