Stock Market Turns Deeply Green On Tuesday – $AAPL $AI $ARKK $ATOS $MLTX $SHIP TSLA Rise!

Happy Tuesday!

I hope that the second day of the week treated you better than you could have hoped.

As for the broad markets today, stocks were up solidly and widely today after the recent couple of days of selloff. The macroeconomic schedule produced a number of reports including the Total durable goods orders repot that came in 1.7% higher M/M in May. The FHFA Housing Price Index report also confirmed an increase of .7% in April. The S&P Case-Shiller Home Price Index report showed a 1.7% drop in April. The Conference Board’s Consumer Confidence Index report exhibited a significant mover up to 109.7 in June. The New home sales report showed a 12.2% M/M jump in May to a seasonally adjusted annual rate of 763k units & on a Y/Y basis, new home sales have moved up 20%. Crude oil prices chunked lower by 1.93% to close at $68.03/bbl, however, the yield curve edged higher as the 2-yr note yield moved up 2bps at 4.76% and the 10-yr note yield moved up 5 basis points to 3.77%, while the U.S. Dollar Index also closed at 102.51 down .18%.

The S&P 500 closed at 4,378.41 (+1.15%) as the majority of sectors closed higher with the consumer discretionary sector up 2.1% and the information technology sector up 2% led all. The heavily-weighted and recently hot technology giant Apple (AAPL) closed at $188.06, +1.51% & EV-maker Tesla (TSLA) rose 3.80% to close at $250.21, +3.80%.

The Dow 30 stayed  below the 34k level and closed at 33,926.74 (+.63%). Disney (DIS, $89.06, +.41%). Walgreens Boots Alliance, Inc. (WBA, $28.64, -9.34%) today announced financial results for the third quarter of fiscal 2023, which ended May 31, 2023, while revising Full-Year Guidance to reflect Consumer Market Trends and lower COVID-19 demand. Chief Executive Officer Rosalind Brewer said: “WBA achieved 8.9 percent constant currency sales growth in the third quarter despite a challenging operating environment. Consumers continue to appreciate the value, convenience, and range of services provided by Walgreens and Boots. However, significantly lower demand for COVID-related services, a more cautious and value-driven consumer, and a recently weaker respiratory season created margin pressures in the quarter. Our revised guidance takes an appropriately cautious forward view in light of consumer spending uncertainty, while still demonstrating clear drivers of a return to operating growth next fiscal year. We are raising our cost savings program target to $4.1 billion and taking immediate actions to optimize profitability for our U.S. Healthcare segment. I am confident that our turnaround strategy positions WBA to drive sustainable core growth and deliver long-term shareholder value.”

The Nasdaq made the largest mover higher today as it closed at 13,555.67 (+1.65%), while Cathie Wood’s ARK Innovation ETF (ARKK) closed at $43.32, +3.39%. NVIDIA Corporation (NVDA) rose 3.06% to close at $418.76. NVIDIA will present at the following event for the Piper Sandler Webinar: Networks for AI, Wednesday, June 28, 9 a.m. Pacific time Interested parties can listen to the live audio webcast of NVIDIA presentations at financial events at investor.nvidia.com. Intel Corporation (INTC) closed at $34.10, (+2.28%). On June 22, 2023, Argonne National Laboratory, Intel and HPE announced that the installation progress of the Aurora Supercomputer is complete.

The growth oriented small caps moved nicely positive today as the Russell 2000 closed at 1,849.93 (+1.46%) & the MicroCaps moved higher broadly as the Micro-cap ETF (IWC) closed at 107.71, +1.06%.

Banks stocks moved up again today as The SPDR S&P Regional Banking ETF (KRE) rose 1.70% to close at $40.76 & the SPDR S&P Bank ETF (KBE) moved up by 1.54% to close at $35.70.   

Biotech stocks on the SPDR S&P Biotech ETF (XBI) closed at $82.92, -.30%.  The 52-wk range is $72.44, – $95.18 and continues to get tighter. The iShares Biotechnology ETF (IBB) moved lower to close at $125.53, -1.21%. The 52-range is $113.37 – $138.74.

MoonLake Immunotherapeutics (Nasdaq: MLTX, $51.79, +95.88% over the last 5-days), a clinical-stage biotechnology company focused on creating next-level therapies for inflammatory diseases, announced on June 25 positive top-line results from its global Phase 2 MIRA trial evaluating the efficacy and safety of the Nanobody® sonelokimab in patients with moderate-to-severe hidradenitis suppurativa (HS). Moonlake also announced that it has commenced an underwritten public offering of $250 million of its Class A ordinary shares and, in lieu of Class A ordinary shares to certain investors that so choose, pre-funded warrants to purchase Class A ordinary shares. In addition, MoonLake is expected to grant the underwriters of the offering an option for a period of 30 days to purchase up to an additional $37.5 million of its Class A ordinary shares at the public offering price, less the underwriting discounts and commissions. 

The iShares U.S. Healthcare ETF (IYH) closed at $276.89, -.60%. The multi-billion-dollar global fertility market is predicted to reach approximately US$47.9 billion by 2030, yet remains severely underserved with many patients (upwards of 90% by many estimates) unable to access affordable treatment.

Today, INVO Bioscience, Inc. (NASDAQ: INVO,  $.2190 and up $.223, +1.83% in the aftermarket), a commercial-stage fertility company focused on expanding access to advanced treatment worldwide with its INVOcell® medical device and the intravaginal culture (“IVC”) procedure it enables, announced it has received U.S. Food and Drug Administration (FDA) 510(k) clearance to expand the labeling on the INVOcell device and its indication for use to provide for a 5-day incubation period. The data supporting the expanded 5-day incubation clearance demonstrated improved patient outcomes. Steve Shum, CEO of INVO stated, “This is a momentous day for INVO as the FDA has provided clearance for us to expand our labeling to cover a 5-day incubation period for INVOcell. This has been a multi-year effort to demonstrate INVOcell’s ability to improve patient outcomes using a longer incubation period, similar to conventional IVF results. We believe our ability to now communicate the improved success rates using INVOcell to patients and physicians will have a positive effect on the overall confidence and adoption of the technology going forward. The global fertility services market is a substantial, multi-billion-dollar industry and growing, with a significant underserved patient population. INVO’s commercial strategy remains focused on helping to expand affordable care to the underserved patients in need. The Company’s market approach includes the opening of dedicated “INVO Centers” offering INVOcell® and IVC procedure (three centers in North America now operational), the acquisition of existing profitable IVF clinics (signed binding agreements to acquire Wisconsin Fertility Institute), and the continued global distribution and sale of the INVOcell technology solution into existing fertility clinics. We believe the recent 510(k) clearance will help further support our overall commercial activities.”

Around the crypto and precious metals’ tree, Bitcoin (BTC) traded to $30,718.41, +1.79% over the last 24 hours at the time of this writing. Gold prices closed still below 2k at $1,917, -$9/oz. & silver closed at $22.87, +$.06/oz. on the day. Two mining producers closed the day as follows: Hecla Mining Company (HL) closed at $5.01, -2.72% & First Majestic (AG, $5.43, +.37%).  

The CBOE Volatility Index (^VIX) closed at $13.74, -3.58%. 

FURTHER AFIELD 

Shares of C3.ai, Inc. (NYSE: AI), the Enterprise AI application software company, moved up to close at $33.37,+4.41%. On May 31, AI announced financial results for its fiscal fourth quarter and full fiscal year ended April 30, 2023. Highlighting Total revenue for the quarter was $72.4 million. C3.ai is hosting an Investor Day on June 22, 2023 in New York City to provide C3 AI investors with a company update, including information about our product roadmap, product demonstrations including C3 Generative AI, and updates on our partner ecosystem. 

Shares of ADT Inc. (ADT), the most trusted brand in smart home and small business security, closed at $5.89, -1.01%. On May 2, ADT reported results for the first quarter of 2023 highlighting strong year-over-year growth in revenue; CSB and Commercial up 7% and 15%, respectively, versus prior year period, maintained record high customer retention and new record high recurring monthly revenue balance, improved capital efficiency with record revenue payback, & continued deleveraging with over $400 million debt reduction expected in 2023.

Shares of Seanergy Maritime Holdings Corp. (SHIP), the only pure-play Capesize ship-owner publicly listed in the U.S. closed at $4.44, +3.26%.  On June 13, SHIP released its Q1 financial results and issued a share dividend of $.025 per share. Its spinoff, United Maritime Corp., also released Q1 financial results, with a share dividend of $0.075 per share. Despite what the company described as a seasonally weak quarter, Seanergy outperformed the daily average of the industry Baltic Capesize Index (“BCI”) of $9,144, achieving a daily Time Charter Equivalent (TCE) of $11,005. The company attributes these remarkable results, in part, to the quality of its vessels and its strategic hedging. Despite the seasonally weaker quarter, Seanergy demonstrated resilience, with an adjusted net loss of $0.3 million and cash and cash equivalents amounting to $20.5 million as of March 31, 2023. The company maintains a positive outlook for the rest of 2023, as evident by the board’s approval of the latest share dividend. With this decision, the total cash dividends now amount to $1.30 per share, or $23.4 million declared since March 2022, in addition to dividends from the successful spinoff United Maritime.

On May 15, INVO Bioscience, Inc. (NASDAQ: INVO, $.2190 and up $.223, +1.83% in the aftermarket) offers the INVOcell solution which provides an advanced, effective and affordable infertility treatment to help increase access to care is commercially advancing INVOcell through the opening of INVO Centers, opportunistically now pursuing acquisitions of established fertility (IVF) clinics in the U.S., and continuing to offer the technology to existing fertility practices, announced financial results for the quarter ended March 31, 2023 and provided a business update. Steve Shum, CEO of INVO stated, “We made significant progress on nearly every key operational metric during the first quarter, particularly within our three existing INVO Centers in Atlanta, Birmingham and Monterrey achieving record levels of revenue and patient cycles. These three centers combined to generate $646,707 in revenue, an increase of 108% from the first quarter of the prior year and were ahead 46% sequentially from Q4 2022, as patients increasingly recognize and value the remarkable opportunity INVO offers to assist families with affordable fertility options. We are extremely pleased to see the existing clinics nearing break-even and look forward to each of them generating positive cashflows and profits in the near future. Tampa Fertility Institute, our planned INVO Center in Tampa, is progressing with a mid-summer target opening and we are also executing on the early preparation work for an INVO Center in Kansas City. To build on the success we are achieving with our INVO Centers, we expanded our commercialization approach to include the acquisition of established and profitable US IVF clinics and announced the execution of binding agreements to acquire Wisconsin Fertility Institute,” Shum continued. “We view our acquisition strategy as highly complementary to our ongoing efforts to build new INVO Centers, increase sales of our INVOcell® device and expand adoption of the IVC procedure. We expect this strategy to accelerate our corporate development efforts and our path to profitability, as we integrate IVC alongside IVF. We view these two procedures as highly complementary to each other and to our mission of expanding access and affordability for the millions of people for whom the cost of IVF is out of reach. We look forward to closing the acquisition in the current quarter.”

On April 18, Maxim Group’s Analyst Jason McCarthy, Ph.D. issued a BUY rating on INVO Bioscience (INVO). His report is titled, “4Q Results and Outlook: Fertility Space Remains Active as INVO Expands Strategy with IVF Clinic Acquisition.” His 12-month Price Target is $3. 

On April 5, INVO announced that it congratulates recently acquires Wisconsin Fertility Institute on being named one of America’s Best Fertility Clinics by Newsweek. During the survey period from November to December 2022, Newsweek and Statista invited over 3,000 reproductive endocrinologists, infertility specialists, obstetricians/gynecologists working in and referring patients to fertility clinics, other medical professionals (e.g., registered nurses, laboratory assistants) and fertility clinic administrators/managers working in fertility clinics to participate in the survey. Participants were asked to assess the quality in five categories for each recommended facility and to assign a ranking position to a set of fertility clinics. Only facilities defined as fertility clinics and ART (“Advanced Reproductive Technology”) providers by the Centers for Disease Control and Prevention (CDC) were considered. Click here for a full listing and methodology for inclusion.

On March 27, INVO Bioscience announced the closing of its previously announced registered direct offering of 3,680,000 shares of common stock (or pre-funded warrants in lieu thereof), priced at-the-market under Nasdaq rules. In a concurrent private placement, the Company also issued warrants to purchase up to an aggregate of 5,520,000 shares of common stock. The combined effective offering price for each share of common stock (or pre-funded warrant in lieu thereof) and warrant is $.815. The warrants are immediately exercisable, expire on the eight-year anniversary of the issuance date and have an exercise price of $0.63 per share. Maxim Group LLC is acting as the sole placement agent for the offering.

On Jan. 16, BioSpectrum published an article titled “INVO Bioscience introduces next-gen technologies to fertility market in Taiwan.”

On Jan. 5, INVO Bioscience announced it has entered an exclusive distribution agreement with Ming Mei Technology Co. Ltd (“Ming Mei”) for Taiwan. The agreement will have an initial 1-year term with renewals. Ming Mei is a leading distributor of fertility-based devices and components in Taiwan helping to bring the latest and most advanced medical equipment into the region. Ming Mei estimates it has approximately 90% coverage of reagents and consumables in the reproductive medicine market in Taiwan. With strong customer relationships in the region, and their familiarity with the field of reproductive medicine, Ming Mei is ideally suited to expand distribution of INVOcell in Taiwan. Taiwan is a destination for assisted reproductive technology (ART) throughout Asia and also has the lowest birthrate in the world. Taiwan’s birth rate has dropped as a result of similar trends elsewhere in Asia, such as later marriage and increasing cost of living. Further, the average age of patients requiring therapy is rising. Fortunately, according to the statistics published by “ICMART”, the overall implantation rate of therapy in Taiwan ranked second worldwide, almost equal to the level in the U.S., and a leading country in Asia. The stable high success rate derives from updated medical research and enriched clinical experience from the physicians, advanced laboratory facilities and technology as well as patient-centered customized treatment plans (depending on their age, ovarian functions and causes of infertility, etc.) Prior to the pandemic, in 2019 there were approximately 55,000 ART cases in Taiwan, an increase of approximately 55% compared to 2016. In July 2021, the government in Taiwan implemented a subsidy plan for ART with the goal of encouraging more local married couples to undergo ART treatments. The subsidies are also available to transnational couples in which one spouse holds a Taiwanese ID card.

On Jan. 3, 2023 INVO announced it has signed an agreement with Shelly W. Holmström, M.D. FACOG, to serve as the physician operator for the Company’s thought to be opening Tampa, Florida INVO Center in the mid-dummer time frame.

 

 

Shares of Atossa Therapeutics (ATOS), a clinical-stage biopharmaceutical company seeking to develop innovative medicines in areas of significant unmet medical need in oncology with a current focus on breast cancer and lung injury caused by cancer treatments rose to an intraday high of $.9770 & closed at $.955, +8.50% on 1.7M shares of trading volume.

 

On June 21, Atossa announced that the United States Patent and Trademark Office (USPTO) has granted a new patent (No. 11,680,036) directed to enterically encapsulated endoxifen compositions formulated as a suspension. These include all liquid suspension formulations suitable for oral administration and dispersible tablets, powders, granules, pellets or sprinkles for reconstitution, which are commonly used for pediatric administration. A suspension is a heterogeneous mixture. It differs from a solution, which is a homogeneous mixture, in that the particles in a solution are much smaller and are dissolved in a solvent, therefore staying mixed together. In a suspension, the particles are large, do not dissolve, and will separate. Advantages of suspension formulations may include ease of delivery of low soluble therapeutic agents, increased bioavailability of drug dosage, controlled drug delivery and resistance to degradation. Dr. Steven Quay, Atossa’s President and Chief Executive Officer, “Our new patent covering suspension formulations is important as we continue to learn more about the potential therapeutic role of endoxifen beyond breast cancer and mammographic breast density. Suspension formulations are particularly useful in pediatric applications where drugs are often dosed by weight and delivered via powders or sprinkles mixed with food and dispersible tablets, which are easier for children to ingest compared to tablets.”

On June 12, Atossa announced that the pharmacokinetic (PK) run-in cohort of the Phase 2 EVANGELINE (Endoxifen Versus exemestANe GosEreLIn) study has fully enrolled. EVANGELINE is a randomized non-inferiority trial of Atossa’s patented Selective Estrogen Receptor Modulator (SERM), (Z)-endoxifen, and exemestane plus goserelin as a neoadjuvant treatment for pre-menopausal women with Grade 1 or 2 Estrogen Receptor positive (ER+) / Human Epidermal Growth Factor Receptor 2 negative (HER2-) breast cancer. The PK run-in cohort consists of six patients, all of whom will be treated with (Z)-endoxifen at 40mg/day for four weeks. The goal of the PK run-in cohort is to determine if the 40mg dose delivers steady-state plasma concentrations (Css) between 500 – 1000 ng/mL, which are optimal to target PKCβ1 inhibition and enhance (Z)-endoxifen’s antitumor mechanism of action. Once the optimal dose of (Z)-endoxifen is determined, the Treatment Cohort will commence. Participants in the treatment cohort will receive neoadjuvant treatment for up to six months, followed by surgery. The study is expected to enroll approximately 175 patients at up to 25 sites across the United States.

 

Atossa’s CEO, Steven Quay, M.D., Ph.D., presented at a Tribe Public even titled “Atossa Therapeutics (NASDAQ: ATOS) Redefining Breast Cancer Prevention and Treatment” on Thursday, May 4, 2023. Dr. Quay provided an update on the clinical development of Atossa’s proprietary Selective Estrogen Receptor Modulator (SERM), (Z)-endoxifen, which is currently being investigated in three separate Phase 2 studies. You may view the event at the following link at the Tribe Public YouTube Channel. 

 

 

 

Last week, Lantern Pharma Inc. (NASDAQ: LTRN, $5.17, -1.90% up +20.89% at $6.25 in the aftermarket), an artificial intelligence (“AI”) company developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs and with a mission to transform the cost, pace, and timeline of oncology drug discovery and development, announced that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug (IND) application for LP-184, which is being developed for multiple advanced solid tumors and central nervous system (CNS) cancers. The first-in-human Phase 1A trial for LP-184 is anticipated to launch and dose its first patient during the current quarter. LP-184 is a novel, synthetically-lethal, small molecule that has been developed using insights from Lantern’s AI platform, RADR®. Lantern has been granted multiple Orphan Drug Designations by the FDA for LP-184 in pancreatic cancer, malignant gliomas, and atypical teratoid rhabdoid tumors (ATRT); in addition the FDA granted Rare Pediatric Disease Designation granted for LP-184 in ATRT. The cancer indications being pursued for LP-184 are estimated to have an annual market potential of $11-13 billion; $6-7 billion for solid tumors and $5-6 billion for brain and CNS cancers.

On June 8, Lantern announced it will be leveraging its AI platform, RADR®, in a research collaboration with Bielefeld University (Bielefeld, Germany) to develop antibody-drug conjugates (ADCs) with high therapeutic and antitumor potential. The collaboration will leverage insights from Lantern’s recently developed RADR® AI ADC module in combination with research from Professor Norbert Sewald, Ph.D., the principal investigator for Bielefeld and leader of Magicbullet::reloaded, a European consortium focused on developing novel drug delivery mechanisms, including ADCs. Outcomes from the collaboration are expected to pave the way for next-generation ADCs and other drug conjugates that are designed using AI and that can be developed with potentially higher efficacy, at a faster pace, and with significantly reduced costs. The collaboration with Bielefeld University (Germany) will be led by Professor Norbert Sewald, Ph.D., a leading expert in the synthesis of cryptophycins, development of ADCs, and the coordinator of the “Magicbullet::reloaded” consortium. Lantern is receiving an exclusive and worldwide option to license intellectual property from Bielefeld University related to the collaboration and IP generated from the collaboration. The global ADC market is currently over $4.0 billion and is projected to reach $14.0 billion by 2027.

 Lantern Pharma’s proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, they have accelerated the development of our growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program. On average, their newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program. Lantern is targeting the $200 Billion current global oncology drug market.

 

 

Chief Executive Officer, President and Director Panna Sharma

Panna Sharma Lantern’s CEO and President stated recently, “As part of our team’s relentless efforts to advance RADR®, we recently developed top-ranked and highly accurate algorithms to predict any compound’s blood-brain-barrier (BBB) permeability, which is one of the major obstacles to developing effective brain cancer drugs. Continued innovations like this will position us for additional high-value biopharma collaborations and will also advance our own AI-powered pipeline of brain and CNS cancer drug candidates.”

Learn more about Lantern at their website https://www.lanternpharma.com. 

Shares of Chinook Therapeutics, Inc. (KDNY), a biopharmaceutical company focused on the discovery, development and commercialization of precision medicines for kidney diseases, closed at $38.58, +.36% after rising +58.32% on June 12 when they announced that it has entered into an agreement and plan of merger with Novartis AG pursuant to which Novartis will acquire Chinook for $40 per share in cash, or a total of $3.2 billion. This offer represents a premium of 83 percent to Chinook’s 60-day volume-weighted average stock price and 67 percent to Chinook’s closing price on June 9, 2023. In addition, Chinook shareholders will receive contingent value rights (CVRs) providing for payment of up to $4 per share upon the achievement of certain future regulatory milestones with respect to Chinook’s lead product candidate, atrasentan. Total consideration including the contingent value right, if the milestones are achieved, would be approximately $3.5 billion. The transaction has been unanimously approved by the Boards of Directors of both companies.`

Economic Reports

On Tuesday, the Total durable goods orders repot that came in 1.7% higher M/M in May. The FHFA Housing Price Index report also confirmed an increase of .7% in April. The S&P Case-Shiller Home Price Index report showed a 1.7% drop in April. The Conference Board’s Consumer Confidence Index report exhibited a significant mover up to 109.7 in June. The New home sales report showed a 12.2% M/M jump in May to a seasonally adjusted annual rate of 763k units & on a Y/Y basis, new home sales have moved up 20%.

Investing & Inspiration

“The future belongs to those who believe in the beauty of their dreams.” – Eleanor Roosevelt

“Never go to bed mad. Stay up and fight.” – Phyllis Diller

“The undertaking of a new action brings new strength.” – Richard L. Evans

“It’s kind of fun to do the impossible.” – Walt Disney

“Real riches are the riches possessed inside.” – B. C. Forbes

“Reject your sense of injury and the injury itself disappears.” – Marcus Aurelius

“It is not enough to have a good mind; the main thing is to use it well.” – Rene Descartes

“A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell

“It takes an endless amount of history to make even a little tradition.” – Henry James”It’s not what you pay a man, but what he costs you that counts.” – Will Rogers

“Halloween is not only about putting on a costume, but it’s about finding the imagination and costume within ourselves.” – Elvis Duran

“Everything in the world may be endured except continual prosperity.” – Johann Wolfgang von Goethe

“Where is all the knowledge we lost with information?” – T. S. Eliot

“All I ask is the chance to prove that money can’t make me happy.” – Spike Milligan

“Out of difficulties grow miracles.” – Jean de la Bruyere

“Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt

“Time is money.” – Benjamin Franklin

“I can, therefore I am.” – Simone Weil

“Where there is no vision, there is no hope.” – George Washington Carver

“Greatness is a road leading towards the unknown.” – Charles de Gaulle

“Kind words do not cost much. Yet they accomplish much.” – Blaise Pascal

“The world is round so that friendship may encircle it.” – Pierre Teilhard de Chardin

“Our deeds determine us, as much as we determine our deeds.” – George Eliot

“The greatest use of a life is to spend it on something that will outlast it.” – William James

Happiness is not something ready made. It comes from your own actions.” – Dalai Lama

“If opportunity doesn’t knock, build a door.” – Milton Berle

“I would define, in brief, the poetry of words as the rhythmical creation of Beauty.” – Edgar Allan Poe

“There are people who have money and people who are rich.” – Coco Chanel

“The young man knows the rules, but the old man knows the exceptions.” – Oliver Wendell Holmes, Sr.

“The past always looks better than it was. It’s only pleasant because it isn’t here.” – Finley Peter Dunne
“With the new day comes new strength and new thoughts.” – Eleanor Roosevelt
“Give me the luxuries of life and I will willingly do without the necessities.” – Frank Lloyd Wright
“To begin, begin.” – William Wordsworth
“You can find peace amidst the storms that threaten you.” – Joseph B. Wirthlin
“Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
“Whenever you find yourself on the side of the majority, it is time to pause and reflect.” – Mark Twain
“Adapt or perish, now as ever, is nature’s inexorable imperative.” – H. G. Wells
“Won’t be long before we view gasoline cars the same way we view steam engines today.” – Elon Musk
“The aim of life is to live, and to live means to be aware, joyously, drunkenly, serenely, divinely aware.” – Henry Miller
“It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare“Opportunity is missed by most people because it is dressed in overalls and looks like work.” – Thomas A. Edison“Experience is one thing you can’t get for nothing.” – Oscar Wilde
“Any sufficiently advanced technology is indistinguishable from magic.” – Arthur C. Clarke
“Good questions outrank easy answers.” – Paul Samuelson
“Thinking: the talking of the soul with itself.” – Plato
“I don’t think of all the misery but of the beauty that still remains.” – Anne Frank
“All money is a matter of belief.” – Adam Smith
“People are not disturbed by things, but by the view they take of them.” – Epictetus
“Uncertainty is seen to retard investment independently of considerations of risk or expected return.” – Ben Bernanke
“I never called my work an ‘art’. It’s part of show business, the business of building entertainment.” – Walt Disney
“Hitch your wagon to a star.” – Ralph Waldo Emerson
“The greatest remedy for anger is delay.” – Lucius Annaeus Seneca
“Great minds discuss ideas; average minds discuss events; small minds discuss people.” – Eleanor Roosevelt
“Act as if what you do makes a difference. It does.” – William James
“Success – keeping your mind awake and your desire asleep.” – Walter Scott
“If I had to live my life again, I’d make the same mistakes, only sooner.” – Tallulah Bankhead
“When one must, one can.” – Charlotte Whitton
“Wealth consists not in having great possessions, but in having few wants.” – Epictetus
“If we open a quarrel between past and present, we shall find that we have lost the future.” – Winston Churchill
“Hope is patience with the lamp lit.” – Tertullian
“A single sunbeam is enough to drive away many shadows.” – Francis of Assisi
“With the past, I have nothing to do; nor with the future. I live now.” – Ralph Waldo Emerson
“Laziness may appear attractive, but work gives satisfaction.” – Anne Frank
“I never think of the future – it comes soon enough.” – Albert Einstein
Hope is but the dream of those who wake.” – Matthew Prior
“The more sand that has escaped from the hourglass of our life, the clearer we should see through it.” – Jean Paul
“Real knowledge is to know the extent of one’s ignorance.” – Confucius
“Better keep yourself clean and bright; you are the window through which you must see the world.” – George Bernard Shaw
“Nothing great in the world has ever been accomplished without passion.” – Georg Wilhelm Friedrich Hegel
“History is a vast early warning system.” – Norman Cousins
“We first make our habits, and then our habits make us.” – John Dryden
“The traveler sees what he sees, the tourist sees what he has come to see.” – Gilbert K. Chesterton
“Adventure is worthwhile.” – Aesop
“We must build dikes of courage to hold back the flood of fear.” – Martin Luther King, Jr.
“The return we reap from generous actions is not always evident.” – Francesco Guicciardini
“Courage is knowing what not to fear.” – Plato
“Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
“Progress was all right. Only it went on too long.” – James Thurber
“If you would know strength and patience, welcome the company of trees.” – Hal Borland
“We aim above the mark to hit the mark.” – Ralph Waldo Emerson
“Hope is being able to see that there is light despite all of the darkness.” – Desmond Tutu
“Our chief want is someone who will inspire us to be what we know we could be.” – Ralph Waldo Emerson
“Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
“Great things are done when men and mountains meet.” – William Blake
“The man who has no imagination has no wings.” – Muhammad Ali
“Formula for success: rise early, work hard, strike oil.” – J. Paul Getty
“Action is the foundational key to all success.” – Pablo Picasso
“Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.” – Samuel Smiles
“The backbone of surprise is fusing speed with secrecy.” – Carl von Clausewitz
“There are no shortcuts in evolution.” – Louis D. Brandeis
“I am fascinated by what is beautiful, strong, healthy, what is living. I seek harmony.” – Leni Riefenstahl
“If one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours.” – Henry David Thoreau
“Waste no more time arguing about what a good man should be. Be one.” – Marcus Aurelius
“It is during our darkest moments that we must focus to see the light.” – Aristotle Onassis
“Courage is fear holding on a minute longer.” – George S. Patton
“You must be the change you wish to see in the world.” – Mahatma Gandhi
“Don’t judge each day by the harvest you reap but by the seeds that you plant.” – Robert Louis Stevenson
“It is in the character of very few men to honor without envy a friend who has prospered.” – Aeschylus
“Life is a series of natural and spontaneous changes. Don’t resist them – that only creates sorrow. Let reality be reality. Let things flow naturally forward in whatever way they like.” – Lao Tzu
“The more you praise and celebrate your life, the more there is in life to celebrate.” – Oprah Winfrey
“Anything simple always interests me.” – David Hockney
“He who angers you conquers you.” – Elizabeth Kenny
“Concision in style, precision in thought, decision in life.” – Victor Hugo
“The secret of genius is to carry the spirit of the child into old age, which means never losing your enthusiasm.” – Aldous Huxley
“View health as an investment, not an expense.” – John Quelch
“The most effective way to do it, is to do it.” – Amelia Earhart
“Man needs his difficulties because they are necessary to enjoy success.” – A. P. J. Abdul Kalam
“Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha
“Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
“You must do the things you think you cannot do.”- Eleanor Roosevelt
“Success is dependent on effort.” – Sophocles
“Nobody who ever gave his best regretted it.” – George Halas
“Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
“And when I breathed, my breath was lightning.” – Black Elk
“Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
“You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
“If you want a guarantee, buy a toaster.” – Clint Eastwood
“We are an impossibility in an impossible universe.” – Ray Bradbury
“If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
“I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
“Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
“It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
“Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
Surprise is the greatest gift which life can grant us.” – Boris Pasternak
“Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran
“Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
“All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
“There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” – Colin Powell
“There is more to life than increasing its speed.” – Mahatma Gandhi
“Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
“Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
“Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
“In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
“Life is too short for long-term grudges.” – Elon Musk
“There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
“Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
“The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
“Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
“Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
“But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
“Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
“Let there be work, bread, water and salt for all.” – Nelson Mandela
“The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
“A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
“I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
“It is the fight alone that pleases us, not the victory.” – Blaise Pascal
“If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
“Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
“Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
“Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
“You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
“Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
“Delete the negative; accentuate the positive!” – Donna Karan
“It’s crazy how fast time flies and how things progress.” – Nathan Chen
“The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
“Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
“Everything has beauty, but not everyone sees it.” – Confucius
“A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
“Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
“A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
“The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
“Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
“I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
“Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
“But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
“Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
“Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
“No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
“Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
“Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
“Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
“If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
“Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
“The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
“There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
“There is little that can withstand a man who can conquer himself.” – Louis XIV
“In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
“A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
“The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
“Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese
“Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
“Never do anything against conscience even if the state demands it.”– Albert Einstein
“Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
“The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
“In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
“A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
“The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
“Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
“Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
“Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
“No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch
“Start where you are. Use what you have. Do what you can.”– Arthur Ashe
“The secret of getting ahead is getting started.” – Mark Twain
“The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe