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Large Caps Trend Lower As Russell 2000 & Biotechs Turn Green On Tuesday – $FATE $INMB $TSLA $XBI Rise!

By John F. Heerdink, Jr.
“Aim for the moon. If you miss, you may hit a star.” – W. Clement Stone, American Businessman, May 4, 1902 – September 3, 2002


Happy Tuesday!

I hope that you all had a wonderful holiday, you enjoyed the San Francisco Giants beat the Los Angles Dodgers last night, and that Tuesday followed up with a few boosts to your investment accounts.  As for the markets, it was a tale of two stories to some degree, as the large caps closed in the red today, while the small caps turned green.   The S&P 500 closed at 4,350.65 (-.24%), the Dow 30 closed at 34,378.34 (-.34%), & the Nasdaq closed at 14,465.93 (-.14%) as the large caps tripped lower when 6 of the 11 sectors closed in the red. On the positive side, the real estate sector led the day with a +1.3% move, while the consumer discretionary and the utilities sectors followed up equally with a +.7% move. The small caps on the Russell 2000 also caught a bid and closed higher at 2,234.27 (+.61%) as did the MicroCaps as the iShares Micro-Cap ETF (IWC) closed at $145.88, (+.65%). 

The macroeconomic schedule produced the Job openings report, which confirmed a drop to 10.439M in August & the NFIB Small Business Optimism Index report for September confirmed a drop  to 99.1. Tomorrow’s macroeconomic schedule will produce the Consumer Price Index for September, the weekly MBA Mortgage Applications Index report, & the September meeting’s FOMC Minutes.

The 2-yr yield moved up 4 basis points to close at .35%, while the 10-yr yield fell 3 basis points to close at 1.58%. The U.S. Dollar Index moved up .2% to close at 94.51.

Oil prices closed higher once again at $80.62/bbl, +.1%. 

GOLD/SILVER DROPS

The precious metals markets ended with gold prices closing at $1,762, +$7/oz. and silver closed at $22.59 flat on the day. 

BIOTECH BUMPS HIGHER

The SPDR S&P Biotech ETF (XBI) closed at $124.61, +.44%, the iShares Nasdaq Biotechnology ETF (IBB) closed at $154.69, +.12% & the NYSE ARCA Biotech Index (^BTK) closed at $5,597.50, +.50%.

Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Ridgeback Biotherapeutics today announced that Merck has submitted an Emergency Use Authorization (EUA) application to the U.S. Food and Drug Administration (FDA) for molnupiravir, an investigational oral antiviral medicine, for the treatment of mild-to-moderate COVID-19 in adults who are at risk for progressing to severe COVID-19 and/or hospitalization. The companies are actively working with regulatory agencies worldwide to submit applications for emergency use or marketing authorization in the coming months.


Shares of INmune Bio (NASDAQ: INMB) closed at $18.43, +3.31% on Tuesday, nearly +7% in 2 days this week. I hosted a FREE Tribe Public Presentation and Q&A event with INMB management,  Thursday, September 30. INmune Bio’s (NASDAQ: INMB) CEO Dr. Raymond J. Tesi, MD and CFO David J. Moss delivered their presentation titled “Improving White Matter Integrity In Alzheimer’s Disease” & and were available for a brief Q&A session. Please view the video now to learn more. 


AAPL, DISNEY, TSLA…

Shares of The Walt Disney Company (DIS) closed at $173.13, -.22%. Disney will discuss fiscal full year and fourth quarter 2021 financial results via a live audio webcast beginning at 4:30 p.m. ET / 1:30 p.m. PT on Wednesday, November 10, 2021. Results will be released after the close of regular trading on November 10, 2021. To listen to the webcast, please visit www.disney.com/investors.

Tesla (TSLA) closed at $805.72, +1.74%. On Monday, Tesla announced the production of approximately 238,000 vehicles & the delivery of over 240,000 vehicles in Q3. 

Apple (AAPL) closes at $141.51, -.91%.  Reportedly, Apple, whose CarPlay interface is used by motorists to control music, get directions & make phone calls, is now seeking looking increase its reach within cars. 

Shares of Microsoft Corp. (MSFT) closed at  $292.88, -.46%. According to Bloomberg, Former Amazon.com Inc. (AMZN) cloud computing executive Charlie Bell began his new role Monday working on cybersecurity issues at Microsoft Corp. after the rival companies resolved a dispute regarding the limits of his job, Microsoft said.


MEMES WATCH

AMC Entertainment (AMC) closed at $37.25, +.16%.  On Monday, Fathom Events, one of the top distributors of content to movie theaters in North America, which is owned by AMC Entertainment Inc. (NYSE: AMC); Cinemark Holdings, Inc. (NYSE: CNK); and Regal Cinemas, a subsidiary of the Cineworld Group (LSE: CINE.L), grossed more than $3.2 million dollars at the US box office this week marking its first multi-million sales week since COVID 19 shuttered theaters. God’s Not Dead: We The People (Pinnacle Peak Pictures) grossed close to $1.2MM over a three-day window, Studio Ghibli Fest 2021: Spirited Away 20th Anniversary (GKIDS) grossed over $865,000, After We Fell (Voltage Pictures) grossed $842,000, Universal Monsters: Dracula & Frankenstein Double Feature (Universal Pictures) grossed $151,000, and The Evil Dead 40th Anniversary (Grindhouse Releasing) reported a box office of $199,000.

GameStop (GME) closed at $178.10, +3.14%.  

Virgin Galactic Holdings (SPCE), a vertically integrated aerospace and space travel company, closed at $23.22, +.43%.  On September 29th, Virgin Galactic announced that it is cleared to fly FAA-licensed spaceflights following the conclusion of an FAA inquiry that focused on air traffic control clearance and real-time mission notification related to the Unity 22 flight in July.

Shares of infamous ‘meme brokerage’ firm Robinhood Markets, Inc., (HOOD) closed at $42.07, +.69% & above the $38 IPO offering price. HOOD had 22.5 million funded accounts at the end of June.

Shares of Seanergy Maritime Holdings Corp. (SHIP) closed at $1.41, +2.17%.

ENPH HOPS

Enphase Energy (ENPH) moved up 4.47% to close at $161.26. No news surfaced today, but on October 4, Enphase, a global energy technology company and the world’s leading supplier of microinverter-based solar-plus-storage systems, today announced it has further strengthened its presence in the European residential solar market with its expansion into Italy. Enphase will provide the IQ 7™ family of microinverters to residential installers across Italy. The Enphase microinverter systems for Italy include the IQ 7 family of microinverters, the Q-Relay™ safety devices, and the Enphase Envoy™ communications gateways, which connect Enphase systems to the Enphase Enlighten™ monitoring platform and make per-panel energy monitoring and insights for operations and maintenance easy. The Enphase microinverter systems meet Italy’s stringent regulatory requirement (CEI 0-21).

VP WATCHLIST HIGHLIGHTS

Our complete VP Watchlist is a list that we believe deserves consideration for short term and long term portfolio adds that include Apple, Tesla, Disney & 8 other names currently. The dedicated pages for each of these companies will enable you to stay informed and learn more about these companies daily. Please review few of the updates on a few of the VP Watchlist companies below:


  • Shares of VP Watchlist stock, INmune Bio (NASDAQ: INMB) closed trading at $18.43, +3.31% ( nearly +7% this week) after reaching an intraday high of $18.60. 
    • I hosted a FREE Tribe Public Presentation and Q&A event with INMB management today, Thursday, September 30 at 8:30am PT/11:30am ET. INmune Bio’s (NASDAQ: INMB) CEO Dr. Raymond J. Tesi, MD and CFO David J. Moss delivered their presentation titled “Improving White Matter Integrity In Alzheimer’s Disease” & and were available for a brief Q&A session. Please view the video now to learn more.
    • On Wednesday, Aug. 4th, INmune Bio, Inc. reported its financial results for the second quarter ended June 30, 2021 and provided a business update. Raymond J Tesi, M.D., CEO/CMO of INmuneBio (INMB) stated, “We continue our planning and setup for a Phase 2 clinical trial of our lead candidate, XPRO™ (Xpro1595™), in patients with mild Alzheimer’s disease, which we plan to initiate by year-end. We have already demonstrated that XPRO™ can reduce neuroinflammation and decreases biomarkers of neurodegeneration and improve synaptic function. If successful in Phase 2, we believe XPRO™ has the potential to be among the most significant advancements in the treatment of Alzheimer’s Disease (AD) and other neurodegenerative diseases in many years. At the Alzheimer’s Association International Conference last week, we introduced a new biomarker – Apparent Fiber Density (AFD), a measure of axonal integrity measured by MRI. XPRO™ increases AFD in patients receiving 1mg/kg/week. We believe the novel non-invasive white matter analytics of white matter free water and apparent fiber density will be very useful in the development of XPRO™ in AD, Treatment Resistant Depression (TRD) and the many other CNS indications we hope to attack in the future. Last month, we treated the first patient in the first Phase 1 clinical trial of our NK cell priming platform, INKmune, in high-risk myelodysplastic syndrome (MDS). We are calling INKmune a pseudokine because, in vitro, it converts the resting NK cells into memory-like NK cells that can kill cancer cells as well or better than NK cells treated cytokines such as IL-12, IL-15 and IL-18 alone or in combination.”
    • On July 26th, INmune Bio announced the design of its upcoming Phase 2 clinical trial of XProTM in patients diagnosed with mild Alzheimer’s disease (AD) at AAIC. The announcement was accompanied by the release of additional biomarker data from the Phase 1b AD trial that shows improvement in white matter (myelinated axons) that degenerate in AD patients. READ MORE. 
 

  • Shares of Fate Therapeutics (FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for patients with cancer, closed at $59.07/share, +4.46%. The 52-wk high is $121.16. 
    • On Oct. 1, Fate announced that one oral and four poster presentations for the Company’s induced pluripotent stem cell (iPSC) product platform were accepted for presentation at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) being held November 10-14, 2021. The oral presentation will highlight preclinical data for FT536, the Company’s off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor (CAR) NK cell product candidate that uniquely targets the α3 domain of the MHC class I related proteins A (MICA) and B (MICB). In a recent publication in Cancer Immunology Research (DOI: 10.1158/2326-6066.CIR-19-0483), Kai W. Wucherpfennig, M.D., Ph.D., Chair of the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute and co-leader of the Cancer Immunology Program at Dana-Farber / Harvard Cancer Center, demonstrated that cancers with loss of MHC Class I expression can be effectively targeted with MICA/B α3 domain-specific antibodies to restore NK cell-mediated immunity against solid tumors. The FT536 program is supported by an exclusive license from the Dana-Farber Cancer Institute to intellectual property covering novel antibody fragments binding MICA/B for iPSC-derived cellular therapeutics. The Company expects to submit an Investigational New Drug (IND) application for FT536 in the fourth quarter of 2021 for the treatment of advanced solid tumors, including in combination with monoclonal antibody therapy.
    • On September 15, Fate Therapeutics announced the publication of preclinical data demonstrating that its off-the-shelf, multiplexed-engineered, iPSC-derived NK cell product candidate FT538 exhibits significantly enhanced serial killing and functional persistence compared to peripheral blood NK cells. The superior anti-tumor activity of FT538 was attributable to its novel engineered components, including the knockout of CD38 and the expression of IL-15/IL-15R fusion protein, which were shown to improve metabolic fitness, increase resistance to oxidative stress, and induce transcription of proteins that control NK cell activation and effector function. The data were published in Cell Stem Cell in an online article entitled “Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy”.



  • INVO Bioscience (NASDAQ: INVO) is a medical device company focused on creating alternative treatments for patients diagnosed with infertility and developers of INVOcell®, the world’s only in vivo Intravaginal Culture System. Shares of INVO closed at $3.59, -2.59%, but has traded up to $3.73 in the after markets.  
    • On Oct. 1, INVO announced that it has entered into definitive agreements with institutional and accredited investors and members of INVO Bioscience’s management team to purchase 1,240,763 shares of its common stock at a purchase price of $3.26 per share, in a registered direct offering priced at-the-market under Nasdaq rules, for gross proceeds of approximately $4.0 million. The registered direct offering is expected to close on or about October 5, 2021, subject to the satisfaction of customary closing conditions.
      •  
          • The group of investors includes members of INVO Bioscience’s management team, including Steve Shum, CEO, and Andrea Goren, CFO. Paulson Investment Company, LLC is acting as the exclusive placement agent for the offering. The gross proceeds from the offering are expected to be approximately $4.0 million, before deducting placement agent’s fees and other offering expenses. INVO Bioscience currently intends to use the net proceeds from this registered direct offering for general corporate and working capital purposes.
          • Also, on Oct. 1, INVO entered into a separate Stock Purchase Agreement with Paradigm Opportunities Fund, LP an accredited institutional investor, pursuant to which we will issue to such investor 600,703 shares of their common stock, par value $0.0001 per share for a purchase price of $3.329 per share for an aggregate purchase price of $1,999,740.29. This transaction is set to close on November 30, 2021. The Shares will be issued under the exemption from registration under Section 4(a)(2) and/or Rule 506 of the Securities Act of 1933, as amended. The Purchase Agreement contains a $250,000 break-up fee whereby if either party fails to close, it will be required to pay the non-breaching party a fee of $250,000. The investor under the Purchase Agreement also agreed to a 1-year lock up period with respect to the Shares.
    • On September 9th, INVO Bioscience announced that it has completed the acquisition of a Canadian-based entity that was originally formed to offer INVOcell in Canada. The entity had previously completed a number of important procedures and documentation necessary to establish INVOcell within clinical operations in Canada. INVO Bioscience anticipates leveraging this entity to advance the distribution of INVOcell, and take advantage of the existing product registration which approved the device for sale based on 5-day incubation in the Canadian market. In addition, the Company is initiating the development of joint ventures to establish INVO Centers within the Canadian marketplace, similar to U.S. and Mexico markets, to further drive accelerated adoption of the INVOcell solution while also increasing much needed capacity and patient access within the fertility industry. Steve Shum, CEO of INVO Bioscience, commented, “We believe Canada offers an excellent opportunity to further expand our distribution efforts of INVOcell while also advancing our joint-venture based INVO Center model. With roughly 16% (or 1 in 6) couples in Canada experiencing infertility, a number that has doubled since the 1980s, and with a popultion of 37.74 million, Canada represents a sizable market opportunity. Canada also faces similar issues that hamper other parts of the world, including a large underserved population, access/capacity constraints and affordability challenges. We appreciate the key individuals in Canada that originally created this entity to help promote and bring our INVOcell technology into the marketplace and look forward to bringing greater resources to advance this effort. We anticipate this acquisition will serve as a platform to help accelerate building INVOcell’s presence in Canada.”
    • On September 7th,  INVO Bioscience announced that it has officially opened the Company’s 2nd INVO Center in the United States, based in Atlanta, Georgia after recently opening their first in Birmingham, AL called “Innovative Fertility Specialists, An INVO Center” on August 9th. INVO Centers are further scheduled this year to open in Monterrey, Mexico & the San Francisco Bay Area. This new joint-venture, named “Bloom Fertility, an INVO Center,” will focus on patients in need of advanced fertility care utilizing the efficient, effective, and affordable INVOcell solution. READ THE COMPLETE STORY. 

    • On August 16th, INVO announced their financial and operating results for the second quarter ended June 30, 2021 and provided a business update. Steve Shum , CEO of INVO stated. “Our team made excellent progress during the second quarter of 2021 toward our key objectives, headlined by last week’s official opening of our first INVO Center practice in Birmingham, AlabamaWe feel INVO is now well positioned for success based on the following core foundational elements developed over the past 2 years. We believe there is a substantial underserved patient population with infertility challenges and a real need to expand access to treatment. In our opinion, this is a multi-billion-dollar market expansion opportunity, and INVOcell is well positioned to address the unmet medical need.”
    • On Aug.2, INVO announced the Company’s first Joint Venture INVO Center practice in the United States, based in Birmingham, Alabama, was officially opening on August 9, 2021. Dr. Hammond commented, “With the opening of the country’s first INVOcell medical practice, we are advancing a core mission towards improving access to advanced fertility services for the many patients who would otherwise never have the opportunity. To date, we have already received numerous advanced inquiries via word of mouth and have dozens of patients scheduled for initial patient consultations who are eager to proceed with treatment. As we officially open the center next week, we expect to accelerate our marketing programs with the help of the INVO marketing team to enhance overall patient awareness around Innovative Fertility Specialists, An INVO Center.”
    • Over the past 40+ years, since the first IVF baby was born, the fertility market has grown into a $20+ billion global industry. Here in the U.S., according to the most recent 2019 CDC data, approximately 330,000 IVF cycles were performed across 448 clinics, which implies a roughly $5 billion domestic marketplace. However, this represents only a small portion of the actual market as approximately 90% of infertile couples go untreated each year. There are some real challenges with bridging the gap of treating the volume of patients that need care. Patient affordability and lack of insurance coverage is often the most discussed dynamic, but that is only one part of the challenge. We believe that there is an equal or even greater challenge related to capacity limitations in the industry given the relatively small number of IVF clinics and limited human resources available which are typically only available in major metropolitan areas. We believe that INVO Biosceince’s INVOcell, without the need of expensive lab build outs, can bring much needed capacity additions and access to the market beyond the major metropolitan areas at a more affordable price.


  • Shares of VP Watchlist firm, Seattle-based Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need with a current focus on breast cancer and COVID-19, closed at $3.03, -3.19% on 4.1M shares of trading volume after reaching a high of $3.13 in intraday trading. 
    • On September 30, Atossa announced it has begun to enroll participants in its clinical study of AT-H201 in Australia. The nebulized formulation, AT-H201, is being developed as an inhalation therapy for moderately to severely-ill hospitalized COVID-19 patients and for “long-haul” patients with post-infection pulmonary disease. “Even with vaccines becoming widely available, the COVID-19 pandemic continues to be an urgent global health crisis,” said Steven Quay, M.D., Ph.D., Atossa’s CEO and President. “Enrolling the first two participants in this study marks a significant milestone in our goal of ultimately developing nebulized AT-H201 to improve lung function in patients with active disease, which may reduce the number of patients requiring ventilators, and in ‘long-haul’ patients who have residual pulmonary function damage. Up to one third of hospitalized patients have pulmonary function changes 60 days or more after recovering from COVID. The portability of nebulizers, already routinely used for other chronic lung disease, should allow for treatment at home.”
    • On September 8th, Edward Woo, analyst at Ascendiant Capital Markets issued an update report titled “Q2 about inline. COVID-19 and breast cancer clinical trials expected to start soon should be catalysts for stock” and raided his P/T to $8.50.
    • On Aug 13th, Atossa announced financial results for the fiscal quarter ended June 30, 2021, and provided an update on recent company developments. “We continue to experience encouraging progress in our MBD and COVID-19 programs, with new regulatory approvals being granted in Sweden for a Phase 2 trial in MBD and authorization in Australia to commence a Phase 2 study of AT-H201 for respiratory illness associated with COVID-19. In the meantime, we continue to enjoy a strong balance sheet, which we have significantly expanded over the last three quarters and will facilitate our development plans over the near term. As we actively explore the possibility for strategic expansion into other areas where we might see near-term milestones and results, we also urge all of our shareholders to exercise their right to vote at our special stockholder’s meeting on September 7, 2021. We urge a vote in favor of the proposal to increase authorized shares, which will provide the Company with the flexibility to issue shares as part of these potential acquisitions, collaborations and partnerships, a common strategy successful biotech companies seeking to grow shareholder value employ in order to create a more attractive opportunity for all. We look forward to continuing to update our stockholders on these opportunities as they develop,” stated Dr. Steven Quay, Atossa’s President and Chief Executive Officer.


  • Shares of VP Watchlist stock, InMed Pharmaceuticals, Inc. (NASDAQ: INM), a leading clinical-stage pharmaceutical company developing cannabinoid-based drug candidates for high unmet medical needs and IntegraSyn, a proprietary and cost effective manufacturing approach for synthesized rare cannabinoids, closed trading at $1.47 and is up in the aftermarkets trading $1.58, +7.48%. The 52-wk range is $1.43 – $8.94. 
    • On September 30, INmed announced that it has commenced its Phase 2 clinical trial of INM-755 (cannabinol) cream in the treatment of Epidermolysis Bullosa (“EB”). This marks the first time cannabinol has advanced to a Phase 2 Clinical trial to be studied as a therapeutic option to treat a disease. This study will be taking place at eleven sites across seven countries including Austria, Germany, Greece, France, Italy, Israel and Serbia. Clinical Trial Applications (“CTAs”) have been filed in all participating countries with regulatory authority and ethics committee approvals currently in place in four countries (Austria, France, Greece, Israel). The first site initiation visit was completed at a clinical site in Austria, where screening for eligible patients will begin shortly. “The start of this Phase 2 clinical trial represents a very important step forward to test the efficacy of INM-755 (cannabinol) cream in treating epidermolysis bullosa, a disease that has very few treatment options,” stated Alexandra Mancini, Senior Vice President of Clinical and Regulatory Affairs at InMed. “Based on our earlier studies, we are hopeful that our cannabinol cream will prove to be a safe and effective treatment for people living with this severe genetic skin disease.”
    • I hosted the INM management team on the Tribe Public Network on Tuesday, September 21 for a 30-minute FREE Presentation and Q&A Webinar Event. Eric A. Adams, MIBS, CEO & President of InMed Pharmaceuticals (NASDAQ: INM) & Shane Johnson, MD, Co-Founder of BayMedica delievered a presentation titled “Accelerating The Commercialization of Rare Cannabinoids.” They held a Q&A session at the end of the presentation. You may view the video of the event at the Tribe Public YouTube Channel here.
    • On September 13th, InMed announced that it has entered into a definitive agreement to acquire BayMedica Inc., a private company based in the US that specializes in the manufacturing and commercialization of rare cannabinoids. The Definitive Agreement follows a previously signed letter of intent announced on June 29, 2021. The transaction, which is subject to certain standard closing conditions, is expected to close in the coming weeks. Upon closing, InMed will become a global leader in the manufacturing of rare cannabinoids, with expertise in three distinct and complementary cannabinoid manufacturing approaches. InMed’s proprietary cannabinoid manufacturing process, IntegraSyn™, combined with BayMedica’s synthetic biology and chemical synthesis capabilities, will provide InMed with complete manufacturing flexibility to select the most appropriate, cost-effective method based on the target cannabinoid and appropriate quality specifications for the desired market segment. In parallel to cannabinoid manufacturing, the combined company will continue to explore the therapeutic potential of cannabinoids and novel cannabinoid analogs for pharmaceutical drug development, as well as expand commercial sales of rare cannabinoids to the consumer health and wellness sector. Revenues of BayMedica’s initial rare cannabinoid product, Prodiol® CBC (cannabichromene), have grown steadily since sales commenced in December 2019, with cumulative revenues in excess of US$2.5M. BayMedica leads the industry in large batch production of CBC with current batch sizes of more than 200kg and an ability to increase to metric ton quantities as market demand increases. BayMedica is focused on the wholesale to consumer health and wellness markets, including nutraceuticals, cosmetic, functional food and beverage, as well as animal health markets. In addition to CBC, BayMedica has several high value non-intoxicating rare cannabinoids in various stages of commercial manufacturing scale-up including CBDV, THCV, CBGV, CBT and CBN for the health and wellness markets.

    • On July 9th, Roth Capital Partners analyst Scott Henry, CFA issued an update report with a BUY Rating titled, “INM: Favorable Take on BayMedica LOI” that includes a $11.50 12-Month Price target.
    • On Aug.9th, I published an informative story titled “A Recent Discussion With The CEO of InMed Pharmaceuticals (NASDAQ: INM) Regarding Development Of IntegraSyn™, A Proprietary Manufacturing Approach To Economically Produce Pharmaceutical-Grade Cannabinoids” PLEASE READ NOW.
    • On July 2nd, InMed announced that it had closed the previously announced private placement and after deducting the placement agent fees and estimated offering expenses payable by the Company, the Company received net proceeds of approximately US$11 million. H.C. Wainwright & Co. acted as the exclusive placement agent for the private placement. Under the terms of the private placement, an aggregate of 4,036,327 common shares (or common share equivalents in lieu thereof) and warrants to purchase up to an aggregate of 4,036,327 common shares were purchased, at an effective purchase price of US$2.973 per common share (or common stock equivalent in lieu thereof) and associated warrant. The warrants have an exercise price of US$2.848 per share, are exercisable immediately and have a term of five years. InMed intends to use the net proceeds from the offering to continue pipeline development, advance business development activities and for general working capital purposes.

Markets

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Bond Markets & US Dollar

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Economic Reports

  • On Monday,  no macroeconomic reports surfaced in honor of the the Columbus Day holiday.
  • On Tuesday, the Job openings report confirmed a drop to 10.439M in August & the NFIB Small Business Optimism Index report for September confirmed a drop  to 99.1.

Agriculture & Energy

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Investing & Inspiration

  1. “Aim for the moon. If you miss, you may hit a star.” – W. Clement Stone
  2. “If I had to live my life again, I’d make the same mistakes, only sooner.” – Tallulah Bankhead
  3. “The deal machinations many companies put themselves through, while certainly a bonanza for investment bankers, can confound the typical investor.” – Whitney Tilson
  4. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  5. “Procrastination is the art of keeping up with yesterday.” – Don Marquis
  6. “Do not fear mistakes. You will know failure. Continue to reach out.” – Benjamin Franklin

  7. “Success is peace of mind which is a direct result of self-satisfaction in knowing you did your best to become the best you are capable of becoming.” – John Wooden

  8. “One fails forward toward success.” – Charles Kettering

  9. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  10. “I hear and I forget. I see and I remember. I do and I understand.” – Confucius
  11. “I’m a very strong believer in listening and learning from others.” – Ruth Bader Ginsburg
  12. “Blessed are those who give without remembering and take without forgetting.” – Elizabeth Bibesco
  13. “As you walk down the fairway of life you must smell the roses, for you only get to play one round.” – Ben Hogan
  14. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  15. “Economics is all about consumption. People either spend money now or they use financial instruments – like bonds, stocks and savings accounts – so they can spend more later.” – Adam Davidson
  16. “Ever tried. Ever failed. No matter. Try Again. Fail again. Fail better.” -Samuel Beckett
  17. “In the post-industrial economy, ideas and great minds often provide far greater return on investment than any other resources or capital investments.” – Marvin Ammori
  18. “Work like you don’t need the money. Love like you’ve never been hurt. Dance like nobody’s watching.” – Satchel Paige
  19. “One of the rules I’ve learned is that struggling to try and think your way into making an investment is usually the best way to not have a great outcome.” – Stephen A. Schwarzman
  20. “The secret of business is to know something that nobody else knows.” – Aristotle Onassis
  21. “It takes a long time to grow an old friend.” – John Leonard
  22. “Life is a dream for the wise, a game for the fool, a comedy for the rich, a tragedy for the poor.”– Sholom Aleichem
  23. “The truth is you don’t know what is going to happen tomorrow. Life is a crazy ride, and nothing is guaranteed.” – Eminem
  24. “Man is only great when he acts from passion.” – Benjamin Disraeli
  25. “We need to stop thinking about infrastructure as an economic stimulant and start thinking about it as a strategy. Economic stimulants produce Bridges to Nowhere. Strategic investment in infrastructure produces a foundation for long-term growth.” – Roger McNamee
  26. “We must let go of the life we have planned, so as to accept the one that is waiting for us.” – Joseph Campbell
  27. “Put your heart, mind, and soul into even your smallest acts. This is the secret of success.” – Swami Sivananda
  28. “I can’t change the direction of the wind, but I can adjust my sails to always reach my destination.” – Jimmy Dean
  29. “Companies have too many experts who block innovation. True innovation really comes from perpendicular thinking.” – Peter Diamandis
  30. “By failing to prepare, you are preparing to fail.” – Benjamin Franklin
  31. “We cannot solve our problems with the same thinking we used when we created them.” – Albert Einstein
  32. “When you’re an investor, you can look at the quantitative and qualitative elements of an investment, but there’s a third aspect: What you feel in your gut.” – Kevin O’Leary
  33. “Set your course by the stars, not by the lights of every passing ship.” – Omar N. Bradley
  34. “Do not take life too seriously. You will never get out of it alive.” – Elbert Hubbard
  35. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey 
  36. “Every good painter paints what he is.” – Jackson Pollock
  37. “If you believe in yourself and have dedication and pride – and never quit, you’ll be a winner. The price of victory is high but so are the rewards.” – Bear Bryant
  38. “Your mindset matters. It affects everything – from the business and investment decisions you make, to the way you raise your children, to your stress levels and overall well-being.” – Peter Diamandis
  39. “You cannot have a positive life and a negative mind.” – Joyce Meyer 
  40. “Like wildebeest and zebra migration across the Serengeti, investment managers and consultants, too, have a habit of running together and, every now and then, changing direction.” – Sanjaya Baru
  41. “If people are anything but enthusiastic about the information or ideas that they’re sharing, they’re either not that invested in what they’re doing – or they’re not communicating that investment effectively.” – Ana Kasparian 
  42. “Life consists not in holding good cards but in playing those you hold well.” – Josh Billings 
  43. “Friend, there’s no greater investment in life than in being a people builder. Relationships are more important than our accomplishments.” – Joel Osteen
  44. “It’s only natural that the heavy users help contribute to the investment to keep the Web healthy. That is the most important concept of net neutrality.” – Lowell McAdam
  45. “The more sand that has escaped from the hourglass of our life, the clearer we should see through it.” – Jean Paul 
  46. “Eliminate emotion from your investment program.” -John C. Bogle

  47. “Modern medical advances have helped millions of people live longer, healthier lives. We owe these improvements to decades of investment in medical research.” – Ike Skelton
  48. “In every investment, before I get involved or invest, I always see what the mindset of the founder, the CEO, is.” – Zaza Pachulia
  49. “An investment said to have an 80% chance of success sounds far more attractive than one with a 20% chance of failure. The mind can’t easily recognize that they are the same.” – Daniel Kahneman
  50. “The return on investment in global health is tremendous, and the biggest bang for the buck comes from vaccines. Vaccines are among the most successful and cost-effective health investments in history.” – Seth Berkley
  51. “Few things in the world are more powerful than a positive push. A smile. A world of optimism and hope. A ‘you can do it’ when things are tough.” – Richard M. DeVos
  52. “To be yourself in a world that is constantly trying to make you something else is the greatest accomplishment.” – Ralph Waldo Emerson
  53. “We all have dreams. But in order to make dreams come into reality, it takes an awful lot of determination, dedication, self-discipline, and effort.”  – Jesse Owens
  54. “The pessimist complains about the wind; the optimist expects it to change; the realist adjusts the sails.” – William Arthur Ward- American Writer, Born 1921
  55. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
  56. “The secret of your future is hidden in your daily routine.” – Mike Murdock
  57.  “If somebody puts you down or criticizes you, just keep on believing in yourself and turn it into something positive.” – Leah LaBelle
  58. “Opportunity is missed by most people because it is dressed in overalls and looks like work”. -Thomas A. Edison
  59. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  60. “Human behavior flows from three main sources: desire, emotion, and knowledge.” – Plato

  61. “We are what our thoughts have made us; so take care about what you think. Words are secondary. Thoughts live; they travel far.” – Swami Vivekananda
  62. “Success is not final, failure is not fatal: it is the courage to continue that counts.” – Winston Churchill
  63. “If you don’t know where you are going, any road will get you there.” – Lewis Carroll

  64. “Don’t worry about being a star, worry about doing good work, and all that will come to you.” – Ice Cube

  65. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare

  66. Prediction is very difficult, especially if it’s about the future.” – Niels Bohr (Danish Physicist)
  67. “It is indeed true that the stock market can forecast the business cycle.” -Paul Samuelson

  68. “The wisest rule in investment is: when others are selling, buy. When others are buying, sell. Usually, of course, we do the opposite. When everyone else is buying, we assume they know something we don’t, so we buy. Then people start selling, panic sets in, and we sell too.” – Jonathan Sacks

  69. “What lies behind you and what lies in front of you, pales in comparison to what lies inside of you.” – Ralph Waldo Emerson
  70. “Each new generation born is in effect an invasion of civilization by little barbarians, who must be civilized before it is too late.” – Thomas Sowell
  71. “Life is 10% what happens to you and 90% how you react to it.” – Charles R. Swindoll
  72. “The truth is you don’t know what is going to happen tomorrow. Life is a crazy ride, and nothing is guaranteed.” – Eminem
  73. “View health as an investment, not an expense.” – John Quelch

  74. “Opportunity does not knock, it presents itself when you beat down the door.” – Kyle Chandler

  75. “If you don’t know where you are going, any road will get you there.” – Lewis Carroll
  76. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
  77. “That which does not kill us makes us stronger.” – Friedrich Nietzsche
  78. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  79. “A problem is a chance for you to do your best.”–  Duke Ellington
  80. “The best way to predict the future is to create it.” -Peter Drucker
  81. “I’m involved in the stock market, which is fun and, sometimes, very painful.” – Regis Philbin
  82. “Who owns the future? This is the question at the heart of every stock market.” – John Landgraf
  83. “One of the funny things about the stock market is that every time one person buys, another sells, and both think they are astute.” – William Feather
  84. While I’m sure some millennials are concerned with the ethical issues involved in mining for diamonds, the main reason they steer clear of the gems is because, well, they’re a dumb investment.” – Ana Kasparian
  85. “The wisest rule in investment is: when others are selling, buy. When others are buying, sell. Usually, of course, we do the opposite. When everyone else is buying, we assume they know something we don’t, so we buy. Then people start selling, panic sets in, and we sell too.” – Jonathan Sack
  86. “We must shift our thinking away from short-term gain toward long-term investment and sustainability, and always have the next generations in mind with every decision we make.” –  Deb Haaland
  87. “The only way to have a friend is to be one.” –  Ralph Waldo Emerson
  88. “If you believe in yourself and have dedication and pride – and never quit, you’ll be a winner. The price of victory is high but so are the rewards.” – Bear Bryant
  89. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” -Liya Kebede

  90. “Success is not final, failure is not fatal: it is the courage to continue that counts.”– Winston Churchill
  91. “Our greatest glory is not in never falling, but in rising every time we fall.” – Confucius

  92. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes
  93. “Who controls the past controls the future. Who controls the present controls the past.” – George Orwell
  94. “If you get up in the morning and think the future is going to be better, it is a bright day. Otherwise, it’s not.” – Elon Musk
  95. “The pessimist complains about the wind; the optimist expects it to change; the realist adjusts the sails.” – William Arthur Ward
  96. “Start where you are. Use what you have. Do what you can.” – Arthur Ashe
  97. “Netflix, Amazon, iTunes – whatever platforms emerge – we are looking at as having the same potential that home video had for the movie business. Which means there are entirely new opportunities to monetize our capital investment in content and do so in ways that work for distributors, for consumers and for creators.” – Bob Iger
  98. “When you have no one to answer to, vendetta as investment strategy is as legitimate as anything.” – Carl Icahn

  99. “No other investment yields as great a return as the investment in education. An educated workforce is the foundation of every community and the future of every economy.” – Brad Henry
  100. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  101. “Modern medical advances have helped millions of people live longer, healthier lives.

  102. We owe these improvements to decades of investment in medical research.”– Ike Skelton

  103. “Stock market goes up or down, and you can’t adjust your portfolio based on the whims of the market, so you have to have a strategy in a position and stay true to that strategy and not pay attention to noise that could surround any particular investment.” – John Paulson

  104. “Your mindset matters. It affects everything – from the business and investment decisions you make, to the way you raise your children, to your stress levels and overall well-being.” – Peter Diamandis
  105. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  106. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  107. “I think you have to learn that there’s a company behind every stock and there’s only one real reason why stocks go up. Companies go from doing poorly to doing well or small companies grow to large companies.” – Peter Lynch
  108. “Historically, there has been a bull market in the commodities every 20 or 30 years.” – Jim Rogers
  109. “The markets generally are unpredictable, so that one has to have different scenarios. The idea that you can actually predict what’s going to happen contradicts my way of looking at the market.” – George Soros
  110. “Stop trying to predict the direction of the stock market, the economy or the elections.” – Warren Buffett
  111. “An important key to investing is to remember that stocks are not lottery tickets.” – Peter Lynch
  112. “Learn everyday, but especially from the experiences of others. It’s cheaper!” – John Bogle
  113. “When purchasing depressed stock in troubled companies, seek out the ones with the superior financial positions and avoid the ones with loads of bank debt.” – Peter Lynch
  114. “No stock price is too low for bears or too high for bulls.” – John F. Heerdink, Jr.
  115. “Investment is most successful when it is most businesslike.” – Ben Graham

  116. “Value stocks are about as exciting as watching grass grow, but have you ever noticed just how much your grass grows in a week?” – Christopher Browne

  117. “Even the intelligent investor is likely to need considerable willpower to keep from following the crowd.” – Benjamin Graham
  118. “Individual who cannot master their emotions are ill-suited to profit from the investment process.” – Benjamin Graham
  119. “I made my first investment at age eleven. I was wasting my life until then.” – Warren Buffet
  120. “I don’t look to jump over seven-foot bars; I look around for one-foot bars that I can step over.” — Warren Buffett
  121. “There are only three measurements that tell you nearly everything you need to know about your organization’s overall performance: employee engagement, customer satisfaction, and cash flow. It goes without saying that no company, small or large, can win over the long run without energized employees who believe in the mission and understand how to achieve it.” – Jack Welch, former CEO of GE
  122. “Opportunities come infrequently. When it rains gold, put out the bucket, not the thimble” ― Warren Buffett
  123. “If you buy things you do not need, soon you will have to sell things you need.” – Warren Buffet
  124. “How many millionaires do you know who have become wealthy by investing in savings accounts? I rest my case.” — Robert G. Allen
  125. “It’s far better to buy a wonderful company at a fair price, than a fair company at a wonderful price.” – Warren Buffett
  126. “A market downturn doesn’t bother us. It is an opportunity to increase our ownership of great companies with great management at good prices.” — Warren Buffett
  127. “Every once in a while, the market does something so stupid it takes your breath away.” — Jim Cramer
  128. “The person who starts simply with the idea of getting rich won’t succeed; you must have a larger ambition.” — John D. Rockefeller
  129. “Know what you own, and know why you own it.” – Peter Lynch
  130. “Although it’s easy to forget sometimes, a share is not a lottery ticket… it’s part ownership of a business.” – Peter Lynch
  131. “Wise spending is part of wise investing. And it’s never too late to start.” – Rhonda Katz
  132. “Invest for the long haul. Don’t get too greedy and don’t get too scared.” – Shelby M.C. Davis

  133. “Fear incites human action far more urgently than does the impressive weight of historical evidence.”
    -Jeremy Siegel
  134. “With a good perspective on history, we can have a better understanding of the past and present, and thus a clear vision of the future.” — Carlos Slim Helu
  135. “If we like a business, we’re going to buy as much of it as we can and keep it as long as we can. And when we change our mind, we don’t take half measures.” – Warren Buffett
  136. “The most contrarian thing of all is not to oppose the crowd but to think for yourself.” — Peter Thiel

  137. “Never depend on a single income, make an investment to create a second source.” Warren Buffet

  138. Games are won by players who focus on the playing field –- not by those whose eyes are glued to the scoreboard.”
    ― Warren Buffett
  139. “The key to making money in stocks is not to get scared out of them.” – Peter Lynch
  140. “Courage taught me no matter how bad a crisis gets … any sound investment will eventually pay off.” — Carlos Slim Helu
  141. “Investing puts money to work. The only reason to save money is to invest it.” – Grant Cardone
  142. “As time goes on, I get more and more convinced that the right method of investment is to put fairly large sums into enterprises which one thinks one knows something about and in the management of which one thoroughly believes.” — John Maynard Keynes
  143. “Given a 10% chance of a 100 times payoff, you should take that bet every time.” — Jeff Bezos
  144. “Money is always eager and ready to work for anyone who is ready to employ it.” ― Idowu Koyenikan
  145. The secret to investing is to figure out the value of something – and then pay a lot less.” – Joel Greenblatt
  146. “We don’t have an analytical advantage, we just look in the right place.” – Seth Klarman
  147. “Men, it has been well said, think in herds. It will be seen that they go mad in herds, while they only recover their senses slowly, and one by one.” – Charles Mackay
  148. “It’s not whether you’re right or wrong that’s important, but how much money you make when you’re right and how much you lose when you’re wrong.” – George Soros
  149. “No Price is too low for a bear or too high for a bull.” — Anonymous
  150. “Investment is an asset or item that is purchased with the hope that it will generate income or appreciate in the future.” Anonymous
  151. “Behind every stock is a company. Find out what it’s doing.” — Peter Lynch
  152. “Wise spending is part of wise investing. And it’s never too late to start.” –Rhonda Katz
  153. “It amazes me how people are often more willing to act based on little or no data than to use data that is a challenge to assemble.” ― Robert Shiller
  154. “A bull market is like sex. It feels best just before it ends.” — Barton Biggs
  155. “The investor’s chief problem — even his worst enemy — is likely to be himself.” — Benjamin Graham
  156. “No profession requires more hard work, intelligence, patience, and mental discipline than successful speculation.” – Robert Rhea
  157. “Money is like a sixth sense – and you can’t make use of the other five without it.” – William Somerset Maugham
  158. “Compound interest is the eighth wonder of the world. He who understands it, earns it. He who doesn’t, pays it.” — Albert Einstein
  159. “Never count on making a good sale. Have the purchase price be so attractive that even a mediocre sale gives good results” — Warren Buffett
  160. “The stock market is a device for transferring money from the impatient to the patient.” – Warren Buffett
  161. “Thousands of experts study overbought indicators, head-and-shoulder patterns, put-call ratios, the Fed’s policy on money supply…and they can’t predict markets with any useful consistency, any more than the gizzard squeezers could tell the Roman emperors when the Huns would attack.” – Peter Lynch
  162. “Investing puts money to work. The only reason to save money is to invest it.” – Grant Cardone
  163. “You cannot save time for your future use however you can invest time for your future.” – John F. Heerdink, Jr. 
  164. “Know what you own, and know why you own it.” – Peter Lynch
  165. “Liquidity is only there when you don’t need it.” -Old Proverb
  166. “If you want to be a millionaire, start with a billion dollars and launch a new airline.” – Richard Branson
  167. “Fear incites human action far more urgently than does the impressive weight of historical evidence.” – Jeremy Siegel
  168. “In investing, what is comfortable is rarely profitable.” – Robert Arnott
  169. “Spend each day trying to be a little wiser than you were when you woke up.” – Charlie Munger
  170. “The entrance strategy is actually more important than the exit strategy.” – Edward Lampert
  171. “The rivers don’t drink their own water; Trees don’t eat their own fruits. The sun does not shine for itself, And flowers do not spread their fragrance For themselves. Living for others is a rule of nature” – Pope Francis
  172. “It is impossible to produce superior performance unless you do something different from the majority.” – John Templeton
  173. “An investment in knowledge pays the best interest.” – Benjamin Franklin.
  174. I believe the returns on investment in the poor are just as exciting as successes achieved in the business arena, and they are even more meaningful!” -Bill Gates
  175. “Every portfolio benefits from bonds; they provide a cushion when the stock market hits a rough patch. But avoiding stocks completely could mean your investment won’t grow any faster than the rate of inflation.” – Suze Orman
  176. “The tax on capital gains directly affects investment decisions, the mobility, and flow of risk capital… the ease or difficulty experienced by new ventures in obtaining capital, and thereby the strength and potential for growth in the economy.” – John F. Kennedy
  177. “If all the economists were laid end to end, they’d never reach a conclusion. -George Bernard Shaw
  178. “There are old traders and there are bold traders, but there are very few old, bold traders.”-Ed Seykota
  179. “Let this scenario play out on its own, in its own fashion. As you watch it unfold, you will soon be grateful that you choose the peaceful path. Remember — those who live by the sword, die by the sword.”
  180. “As long as you enjoy investing, you’ll be willing to do the homework and stay in the game.” -Jim Cramer
  181. “I rarely think the market is right. I believe non-dividend stocks aren’t much more than baseball cards. They are worth what you can convince someone to pay for it.” -Mark Cuban
  182. Michael Marcus taught me one other thing that is absolutely critical: You have to be willing to make mistakes regularly; there is nothing wrong with it. Michael taught me about making your best judgment, being wrong, making your next best judgment, being wrong, making your third best judgment, and then doubling your money.” -Bruce Kovner
  183. “The policy of being too cautious is the greatest risk of all.” -Jawaharlal Nehru
  184. “The only true test of whether a stock is “cheap” or “high” is not its current price in relation to some former price, no matter how accustomed we may have become to that former price, but whether the company’s fundamentals are significantly more or less favorable than the current financial-community appraisal of that stock.” -Philip Fisher
  185. “I learned to avoid trying to catch up or double up to recoup losses. I also learned that a certain amount of loss will affect your judgment, so you have to put some time between that loss and the next trade.” -Richard Dennis
  186. “The four most dangerous words in investing are: ‘this time it’s different.” -Sir John Templeton
  187. “Money doesn’t make you happy. I now have $50 million but I was just as happy when I had $48 million.” -Arnold Schwarzenegger
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