As per reports, The Walt Disney Company’s (DIS) latest Marvel film, “The Marvels,” had an opening weekend with domestic and Canadian box office earnings of $47 million, marking the lowest ever debut for the renowned superhero franchise. This result fell within the range of Boxoffice Pro’s estimate of $35 million to $49 million but fell short of the studio’s own prediction of around $60 million. Internationally, the movie raked in $110.3 million.
Historically, Marvel Studios, under the leadership of President Kevin Feige, had been a consistently strong performer in the film industry. With a total of 33 films to its name, the franchise had amassed approximately $30 billion in global box office revenue since the release of “Iron Man” in 2008.
However, the company has recently faced challenges with films like “The Eternals” and “Ant-Man and the Wasp: Quantumania,” which received weaker reviews and generated lower-than-usual revenue. Additionally, some Marvel TV shows produced for Disney’s streaming service, Disney+, such as “She-Hulk: Attorney at Law” and “Secret Invasion,” failed to capture the same level of critical and viewer acclaim.`
Dow 30 Component, The Walt Disney Company (DIS), and its subsidiaries is a diversified worldwide entertainment company that operates in four business segments: Studio Entertainment, Media Networks, Parks and Resorts, and Consumer Products & Interactive Media. To learn more about this Dow 30 Component, The Walt Disney Company (DIS), and to continue to track its progress please visit the Vista Partners Walt Disney Company, Coverage Page.
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DID YOU KNOW?
Lantern (LTRN) is an Artificial Intelligence (AI) firm that is transforming the cost, pace, and timeline of oncology drug discovery and development and specifically is developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs.
- Received IND clearance from FDA to initiate Phase 1 clinical trial for LP-284, a first-in-human trial for advanced, refractory non-Hodgkin’s lymphomas (NHL).
- Dosed initial patient in Phase 1 with LP-184, a clinical trial for multiple advanced solid tumors that are refractory to standard-of-care therapies.
- Progressed Phase 2 LP-300 Harmonic™ clinical trial towards enrollment in East Asian countries where 30-35+% of all lung cancer cases occur in never-smokers with NSCLC; continued expansion of additional clinical trial sites in the US and increased focus on recruitment activity with advocacy groups.
- Developed initial proof-of-concept and preclinical evidence for a novel cryptophycin-based ADC (antibody-drug conjugate); initial data is planned to be shared in January 2024.
- Furthered development of Lantern’s AI platform, RADR®, to include modules for the streamlined development of ADCs and the prediction of drug combinations with existing approved checkpoint inhibitors.
- Approximately $45 million in cash, cash equivalents, and marketable securities as of September 30, 2023, is anticipated to provide a cash runway into at least Q3 of 2025.
As a quick follow up to Tribe Public’s recent CEO Presentation events that were held on the West Coast, our sister organization held a brief webinar-based Q&A session with Panna Sharma, CEO of Lantern, to have him address a few questions. The video has now ben published at the Tribe Public YouTube Channel the brief ~10-minute informative session can be viewed now by clicking here.
Lantern Pharma will host its third quarter 2023 operating and financial results webcast on Wednesday, November 8, 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time. Management intends to discuss the operating and financial results for the third quarter ended September 30, 2023 and provide guidance on upcoming milestones, clinical trials and developments of the A.I. platform, RADR®. Panna Sharma, President and Chief Executive Officer of Lantern Pharma, will lead the call and will be joined by other members of the management team. To register for the webinar, please sign up at the Zoom webcast link provided in the link: Lantern Pharma Q3, 2023 earnings Zoom webcast registration link. A replay of the earnings call webcast will be available after the call on the investor relations section of the Company’s website: ir.lanternpharma.com.
On Oct. 3, Lantern announced that in vivo data highlighting the enhanced efficacy of Lantern’s drug candidate LP-184 in glioblastoma (GBM) were published in Clinical Cancer Research, a journal of the American Association for Cancer Research. LP-184 is a unique small molecule with low nanomolar activity and favorable CNS penetration. LP-184 utilizes its powerful mechanism of action, known as synthetic lethality, to exploit common vulnerabilities in solid tumor and CNS cancers with DNA damage repair (DDR) deficiencies. In addition, Lantern’s AI platform, RADR®, has highlighted overlapping gene dependency profiles between GBM tumorigenesis and sensitivity to LP-184, such as EGFR activation pathways. The article, entitled “Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma” can be accessed here.
Panna Sharma is the President, CEO, and Board Member of Lantern Pharma Inc.
“The data highlighted in Clinical Cancer Research solidify LP-184 as a promising therapeutic for GBM, with LP-184 having inhibited the viability and growth of multiple GBM models including temozolomide-resistant and MGMT-expressing cells,” stated Panna Sharma, Lantern’s President and CEO.
“The rapid advancement of LP-184 into a first-in-human Phase 1 trial provides strong validation of the power of our AI-enabled approach to drug development. This approach is about more than just developing new treatments, it’s about making them more targeted, more effective, and ultimately doing all of this more efficiently. This publication demonstrates our ability to deliver on these aspirations and introduce new therapeutic programs in areas where there is significant unmet patient need.”
