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Rates Jump, Stocks Pull Back To Clock In Worst Week of 2023 – $CVX $INVO $HSAI $MSFT $NVDA $OXY $TSLA Rise!

By John F. Heerdink, Jr.
Quote of the Day:  “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia


Happy Saturday!

I hope that a wonderful week wherever it landed you and that you managed to make your fair share of profits in the stock market.

This weekend, I am looking forward to enjoying SuperBowl LVII with family and friends like so many others on this planet and am hoping to seeing an entertaining game between the Kansas Chiefs and the Philadelphia Eagles. Thanks for your replies letting me know who you believe will win the game. Our informal Vista poll currently has the Chiefs winning!  If you have not done so, please consider letting me know who you believe will win tomorrow’s game. 

As for the broad markets this week, investors, in general, were treated with a rather rude awakening after the recent overwhelmingly positive “January Effect’ and beginning of February run-up as the markets experienced the worst week of 2023.  Contributing to this decline the macroeconomic schedule offered a number of reports that left investors with the understanding that the Fed’s push to raise interest rates is not quite over and their risk appetite somewhat disappeared. On Tuesday, the December Trade Balance report came in at -$67.4B giving further evidence of a global slowdown. The Consumer credit report also confirmed a $11.6B rise in November. On Wednesday, the Weekly MBA Mortgage Applications Index report came in at 7.4%, while the December Wholesale Inventories report came in at .1%. On Thursday, the Initial claims report for the week ending February 4 that confirmed a 13k rise to 196k, while the Continuing jobless claims report for the week rose by 38k to 1.688M, but overall the jobs market remains tight. On Friday, the Preliminary February University of Michigan Consumer Sentiment Report came in at 66.4 & the Treasury Budget for January confirmed a $38.8B deficit. Key reports coming next week include Tuesday’s CPI inflation data and the retail sales growth report.

As a result, the yield curve jumped higher this week, with the 2-yr note yield moving up 22 basis points to close at 4.51% & the 10-yr note yield closed up 21 basis points at 3.74%. The U.S. Dollar Index moved up again this week from last Friday’s close of 102.99 to 103.58. 

At the end of the week, the S&P 500 closed at 4,090.46 (-1.1%) for the week and is now up 6.5% YTD. Only 1 of the 11 sectors closed in the green as the energy sector jumped 5% as oil prices rebounded from last week’s 8.1% drop to close at $79.79/bbl jumping 8.7% over the last 5-days and is down .6% YTD. The move came in concert with our good ole’ buddies in Russia threatening to cut production by 500k barrels/day in March as they are not happy with international sanctions. On the red side, the communication services took largest hit falling 6.6%. The 6.82% weighting of the shares of Apple (AAPL) helped push the markets lower this week as it closed at $151.01, -2.26% over the last 5-days. However, the shares of EV giant Tesla (TSLA) provided significant strength this week as it closed at $196.89, +3.64% over the last 5-days despite Friday’s 5.03% decline and remains up 59.84% YTD. A government report surfaced this week  that concluded a fatal Tesla car crash in 2021 was not caused by Tesla’s advanced driver-assistance features, but unfortunately do to driving to fast. Tesla’s CEO Elon Musk also made it widely known that he was going to share his ‘Master Plan part 3’ at the upcoming March 1 Investor Day that will be held at his Gigafactory in Texas =, which got many excited.

The Dow 30 slipped to close at 33,869.20 (-.2%) and is now up +2.2% YTD.  The Walt Disney Company (DIS) closed at $108.06, down 2.39% over the last 5-days, but gladly ended its highly active and publicized proxy battle with Trian’s Billionaire Nelson Peltz who stated “Now Disney plans to do everything we wanted them to do. We wish the very best to Bob, this management team and the board. We will be watching. We will be rooting.” This move came a day after Disney reported earnings for its first quarter ended December 31, 2022, highlighting revenues for the quarter grew 8%, diluted earnings per share (EPS) from continuing operations for the quarter increased to $.70 from $0.63 in the prior-year quarter. Robert A. Iger, CEO of Disney Company stated, “After a solid first quarter, we are embarking on a significant transformation, one that will maximize the potential of our world-class creative teams and our unparalleled brands and franchises. We believe the work we are doing to reshape our company around creativity, while reducing expenses, will lead to sustained growth and profitability for our streaming business, better position us to weather future disruption and global economic challenges, and deliver value for our shareholders.” Disney also confirmed that it plans to cut 7k jobs & eliminate $5.5B costs overall. Nike (NKE) closed at $122.23, down 4.22% over the last 5-days.

The Nasdaq cooled off after the mid-double digit run it enjoyed to start the year and closed the week at 11,718.10 (-2.4%) for the week and is up 12% YTD. However, the artificial intelligence (AI) theme and promotion was in full swing again. Shares of Microsoft Corp. (MSFT) closed at $263.10, +1.84% over the last 5-days. On Feb. 8, Adobe (Nasdaq:ADBE) and Microsoft announced that they have taken the next step in their commitment to transform the future of digital work and life by bringing Adobe Acrobat’s PDF capabilities to more than 1.4 billion Microsoft Windows users in Microsoft Edge. Recently, Microsoft raised its investment in OpenAI, ChatGPT’s San Francisco-based developer, and has committed another $10B in ChatGPT, the AI chatbot is reportedly on track to 100M monthly active users (MAUs). On Jan. 31, C3 AI (AI,$22.99 down 11.17% after the previous 5-days where it enjoyed a 45.64% jump), the Enterprise AI application software company, announced the launch of the C3 Generative AI Product Suite with the release of its first product — C3 Generative AI for Enterprise Search. C3 Generative AI for Enterprise Search provides enterprise users with a transformative user experience using a natural language interface to rapidly locate, retrieve, and present all relevant data across the entire corpus of an enterprise’s information systems. The C3 Generative AI Product Suite integrates the latest AI capabilities from organizations such as Open AI, Google, and academia, and the most advanced models, such as ChatGPT and GPT-3 into C3 AI’s enterprise AI products. The C3 Generative AI Product Suite embeds advanced transformer models with C3 AI’s pre-built AI applications accelerating customers’ ability to leverage these models across their value chains. C3 Generative AI will accelerate transformation efforts across business functions and industries, including supply chain, sustainability, reliability, CRM, ESG, aerospace, oil & gas, utilities, CPG, healthcare, financial services, and defense and intelligence. 

Another move in the markets came from Hesai Group (HSAI, $22.20, +5.36% Friday), a Chinese developer of sensor technologies used in self-driving cars, successfully raised $190m IPO or its initial public offering at $19/share and began trading on the Nasdaq valuing it at $2.4B on Thursday. This particularly interesting as there had not been a Chinese US IPO of this size since 2001 as US – China soured politics and trade relations had previously taken over. The IPO schedule in general is building again so hopefully we will see more coming to the market soon. 

The small caps on the Russell 2000 took a solid hit this week after last’s jump & closed at 1,918.81 (-3.4%) for the week & is now up +8.9 YTD. The MicroCaps also faltered widely this week as the iShares Micro-Cap ETF (IWC) closed at $117.29 down 3.63% this week & is now up 8.77% YTD.  

Biotech stocks retreated as well this week. On the larger side of things, the Nasdaq Biotechnology ETF (IBB) moved down and closed at $132.36, -3.10% and is up .89% YTD, the NYSE ARCA Biotech Index (^BTK) closed at 5,453.97, -2.60% over the last 5-days and is now up 3.27% YTD, & the SPDR S&P Biotech ETF (XBI) closed at $85.62, down 5.28% over the last 5-days & is now up 3.16% YTD. The 52-week range is is now $61.78-$97.19. The iShares U.S. Healthcare ETF (IYH) closed at $277.57,-.54% over the last 5-days and is now down 2.16% YTD. 

With the overall negative market swing in the broad markets, the CBOE Volatility Index (^VIX) and volatility lovers won handsomely as it closed at $20.53,  up 12% over the last 5-days and is now down 5.26% YTD.

FURTHER AFIELD 



Shares of JPMorgan (JPM) closed at $141.04, -.04% over the last 5-days. On Feb. 8, Chase announced that it intends to hire more than 500 small business bankers over the next two years as part of the firm’s ongoing efforts to expand small business relationships and increase access to credit, advice and education, while helping small business owners navigate current inflation and concerns of a recession.

Shares of Amazon.com, Inc. (AMZN) closed $97.61, -.64% over the last 5-days. On Feb. 8, S&P Global (NYSE: SPGI) and Amazon Web Services (AWS), an Amazon announced a new multi-year strategic collaboration agreement. With AWS as its preferred cloud provider, S&P Global will enhance its cloud infrastructure, accelerate business growth, engineer new innovations for key industry segments, and help their customers navigate rapidly changing market conditions.

On Feb. 2, Amazon.com, Inc. announced financial results for its fourth quarter ended December 31, 2022. Net sales increased 9% to $149.2 billion in the fourth quarter, compared with $137.4 billion in fourth quarter 2021. Excluding the $5.0 billion unfavorable impact from year-over-year changes in foreign exchange rates throughout the quarter, net sales increased 12% compared with fourth quarter 2021. North America segment sales increased 13% year-over-year to $93.4 billion, or increased 14% excluding changes in foreign exchange rates. International segment sales decreased 8% year-over-year to $34.5 billion, or increased 5% excluding changes in foreign exchange rates. AWS segment sales increased 20% year-over-year to $21.4 billion.Operating income decreased to $2.7 billion in the fourth quarter, compared with $3.5 billion in fourth quarter 2021.


Shares of Microsoft Corp. (MSFT) closed at $263.10, +1.84% over the last 5-days. On Feb. 8, Adobe (Nasdaq:ADBE) and Microsoft announced that they have taken the next step in their commitment to transform the future of digital work and life by bringing Adobe Acrobat’s PDF capabilities to more than 1.4 billion Microsoft Windows users in Microsoft Edge.

Recently, Microsoft raised its investment in OpenAI, ChatGPT’s San Francisco-based developer, and has committed another $10B in ChatGPT, the AI chatbot is reportedly on track to 100M monthly active users (MAUs).


On Jan. 31, C3 AI (NYSE: AI, at $22.99 down 11.17% after the previsous 5-days that saw 45.64% jump), the Enterprise AI application software company, announced last week the launch of the C3 Generative AI Product Suite with the release of its first product — C3 Generative AI for Enterprise Search. C3 Generative AI for Enterprise Search provides enterprise users with a transformative user experience using a natural language interface to rapidly locate, retrieve, and present all relevant data across the entire corpus of an enterprise’s information systems. The C3 Generative AI Product Suite integrates the latest AI capabilities from organizations such as Open AI, Google, and academia, and the most advanced models, such as ChatGPT and GPT-3 into C3 AI’s enterprise AI products. The C3 Generative AI Product Suite embeds advanced transformer models with C3 AI’s pre-built AI applications accelerating customers’ ability to leverage these models across their value chains. C3 Generative AI will accelerate transformation efforts across business functions and industries, including supply chain, sustainability, reliability, CRM, ESG, aerospace, oil & gas, utilities, CPG, healthcare, financial services, and defense and intelligence.


Shares of Salesforce, Inc. (CRM) closed at $167.03, -2.34% over the last five days. Salesforce will release its fourth quarter and full fiscal year 2023 results on Wednesday, Mar. 1, 2023, after the close of the market.


Shares of Intel (INTC) fell 8.31% to close at $30.32 over the last 5-days. On Feb 8, Intel issued “Intel Editorial: Unlocking the Potential of Generative AI” by Ilke Demir of Intel Corporation. It begins as follows: “Generative artificial intelligence (AI) describes the algorithms used to create new data that can resemble human-generated content, including audio, code, images, text, simulations and videos. This technology is trained with existing content and data, creating the potential for applications like natural language processing, computer vision, metaverse and speech synthesis. Generative AI is not new. It’s the tech that created voice assistants, infinitely evolving games, and chatbots…READ The balance of the piece it here.

Shares of NVIDIA (NVDA), a pioneer in accelerated computing, closed at $212.65, +.78% over the last 5-days. NVIDIA will host a conference call on Wednesday, February 22, at 2 p.m. PT (5 p.m. ET) to discuss its financial results for the fourth quarter and fiscal year 2023, which ended January 29, 2023. The call will be webcast live (in listen-only mode) on investor.nvidia.com.

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $39.15, -8.63% over the last 5-days.  

The Technology Select Sector SPDR Fund (XLK) closed at $140.38, -.98% over the last 5-days. 

Shares of McDonald’s (MCD) closed at $262.42, -.69% over the last 5-days.  On Feb, 2, McDonald’s Board of Directors declared a quarterly cash dividend of $1.52 per share of common stock payable on March 15, 2023 to shareholders of record at the close of business on March 1, 2023.

On Jan. 31, McDonald’s Corporation announced results for the fourth quarter and year ended December 31, 2022. Global comparable sales increased over 12% for the quarter, with double-digit growth across all segments.  Digital Systemwide sales* in their top six markets were over $7 billion for the quarter, representing more than 35% of their Systemwide sales. Full year comparable sales grew over 10%, and comparable guest counts grew 5%.


GOLD & SILVER

Gold prices closed at $1869/oz., +$0.00/oz. & silver prices closed at $22.03/oz., -$1.61/oz. for the week.

Hecla Mining (HL) closed at $5.72, -3,70% over the last 5-days after they announced plans to issue a news release reporting its fourth quarter and full-year 2022 operations and financial results before market open on Wednesday, February 15, 2023.

First Majestic (AG) closed at $7.31, -4.82% over the last 5-days. 


MEMES CENTRAL

AMC Entertainment (AMC) closed at $4.90, -19.41% & (APE) closed at $2.30, -23.59% over the last 5-days.  On Feb. 6, AMC Theatres®,the largest theatrical exhibitor in the United States and the world, announced Sightline at AMC – a ticket pricing initiative based on seat location within each auditorium, which provides AMC moviegoers with multiple options to meet their viewing preferences. With Sightline at AMC, moviegoers now have the option to pay less, or more, for a movie ticket based on their seat selection. The initiative has already rolled out to select AMC locations and will be expanded to all domestic AMC and AMC DINE-IN locations by the end of the year.

GameStop (GME) closed at $22.25, -2.50% over the last 5-days as the shorts won overall this week. 

Seanergy Maritime Holdings Corp. (SHIP) closed at $.5980, +3.10% over the last 5-days. On Jan. 20, Seanergy announced an aggregate of $8.8 million of buybacks of its securities consisting of:

(i) $8 million of its outstanding convertible note with 5.5% coupon and a conversion price of $1.20 per share (the “Note”), pursuant to the terms of the Note, and

(ii) $0.8 million in 4,038,114 warrants at $0.2 per warrant, pursuant to the recently completed tender offer. The repurchased securities represent approximately 47% of the outstanding Class E Warrants to purchase an equal number of shares at an exercise price of $0.524 per share.

Moreover, Seanergy’s Chairman & CEO, Stamatis Tsantanis, has since August 2022 purchased 300,000 of the Company’s common shares in the open market.



CRYPTO & BITCOIN

Bitcoin (BTC) closed at $21,607.08, -5.07% over the last 5-days at the time this report was prepared. 


ENERGY

The Energy Select Sector SPDR Fund or ETF (XLE) closed at $90.21, +4.94% over the last 5-days. 

Chevron (CVX) closed at $171.97, +1.49% over the last 5-days. On Feb. 9, Chevron announced that it has been awarded the 2023 Platinum Bell Seal for Workplace Mental Health by Mental Health America (MHA). The Bell Seal is a first-of-its-kind workplace mental health certification that recognizes employers who strive to create mentally healthy workplaces for their employees.

 On Jan. 27, Chevron reported earnings of $6.4 billion ($3.33 per share – diluted) for fourth quarter 2022, compared with $5.1 billion ($2.63 per share – diluted) in fourth quarter 2021. Included in the current quarter were $1.1 billion of international upstream write-off and impairment charges, and pension settlement costs of $17 million. Foreign currency effects decreased earnings by $405 million. Adjusted earnings of $7.9 billion ($4.09 per share – diluted) in fourth quarter 2022 compared to adjusted earnings of $4.9 billion ($2.56 per share – diluted) in fourth quarter 2021. Chevron reported full-year 2022 earnings of $35.5 billion ($18.28 per share – diluted), compared with $15.6 billion ($8.14 per share – diluted) in 2021. Adjusted earnings of $36.5 billion ($18.83 per share – diluted) in 2022 compared to adjusted earnings of $15.6 billion ($8.13 per share – diluted) in 2021. For a reconciliation of adjusted earnings, see Attachment 6. Sales and other operating revenues in fourth quarter 2022 were $55 billion, compared to $46 billion in the year-ago period.

Warren Buffet’s pick in the sector, Occidental Petroleum (OXY) closed at $65.63, +7.17% over the last 5-days. On Jan. 20, Occidental (NYSE:OXY) announced that Claire O’Neill, former Member of Parliament and Minister for Energy and Clean Growth in the UK Government, and a former Managing Director, Climate and Energy of the World Business Council for Sustainable Development (WBCSD), has been elected to its Board of Directors, effective as of January 17, 2023. Occidental will announce its fourth quarter 2022 financial results after close of market on Monday, February 27, 2023, and will hold a conference call to discuss results on Tuesday, February 28, 2023, at 1 p.m. Eastern/12 p.m. Central. The conference call may be accessed by calling 1-866-871-6512 (international callers dial 1-412-317-5417) or via webcast at oxy.com/investors. Participants may pre-register for the conference call at https://dpregister.com/sreg/10173524/f531c7c588.

Oil prices closed on Friday to end at $79.76/bbl and rebounding 7.62% over the last 5-days and is up 3.42% YTD.



NEXT WEEK



The markets will be back up and running for 5 full trading sessions in the stock market again next week.  

VP WATCHLIST UPDATES

Please review a select group of emerging names below and their updates below:

 
 
 
Shares of ADT Inc. (ADT), the most trusted brand in smart home and small business security, closed at $8.31, -2% over the last 5-days, after establishing a new 52-wk high at $10.10 recently. On Jan. 9, ADT announced the appointment of Wayne Thorsen to the newly created role of Executive Vice President and Chief Business Officer, effective immediately. Thorsen will be responsible for leading ADT’s product, innovation and new business development teams. “Wayne is a seasoned executive who brings valuable experience in business development, strategic partnerships and product marketing and development,” said Jim DeVries, ADT President and CEO. “Wayne’s expertise will accelerate our strategy to sustainably grow our business and continue to attract strategic partners by showcasing ADT’s market leadership.”
 
On Oct. 13, ADT, announced that it had issued and sold in a private placement to State Farm 133.3 million shares of ADT common stock for a gross purchase price of $1.2 billion. In September, ADT announced a new partnership with State Farm to revolutionize the homeownership experience through innovation in the detection and mitigation of property losses. In addition to the equity investment, State Farm has committed up to $300 million to fund product and technology innovation, customer growth and marketing activities in connection with the partnership. State Farm has funded the first $100 million and the two companies will collaborate to approve initiatives utilizing the funds.
 
 
 
  • Shares of Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need in oncology, with a current focus on breast cancer and radiation-induced lung injury, closed at $.726, down 12.53% over the last 5-days and but remains up 36.98% YTD. 
    • On Wednesday Jan. 25, Atossa Therapeutics announced the issuance of the following Letter to Shareholders from Steven C. Quay, M.D., Ph.D., the Company’s CEO and Chairman:

      TO OUR VALUED STOCKHOLDERS:

      2022 was a year of significant progress for Atossa. We focused our development efforts on advancing our breast cancer program with our patented (Z)-endoxifen, the highest potency Selective Estrogen Receptor Modifier (SERM). We currently have Phase 2 studies ongoing in the prevention and treatment settings, both focused on areas of unmet medical need. Our goal is to both help reduce the incidence of breast cancer and change the treatment paradigm for patients who are not benefiting from currently approved drugs.

      In October 2022, the U.S. Food and Drug Administration (FDA) authorized the initiation of our EVANGELINE study, a Phase 2 trial of (Z)-endoxifen and Exemestane + Goserelin as neoadjuvant treatment in premenopausal women with ER+/HER2- breast cancer. While there are several FDA-approved neoadjuvant therapies for ER- breast cancers, few exist for the ER+ patients, which account for approximately 78% of breast cancers. We expect to enroll approximately 175 patients at up to 25 sites across the United States.  READ THE BALANCE OF THE PROGRESS REPORT BY CLICKING HERE.

    • Jason McCarthy Ph.D., a biotech analyst at the Maxim Group, put out a note on July 28th reconfirming his BUY rating and a $4 target price on Atossa.
  •  

  • The multi-billion-dollar global fertility market is predicted to reach approximately US$47.9 billion by 2030, yet remains severely underserved with many patients (upwards of 90% by many estimates) unable to access affordable treatment. INVO Bioscience, Inc. (NASDAQ: INVO) offers the INVOcell solution which provides an advanced, effective and affordable infertility treatment to help increase access to care. INVO is commercially advancing INVOcell through the opening of INVO Centers, opportunistically now pursuing acquisitions of established fertility (IVF) clinics in the U.S., and continuing to offer the technology to existing fertility practices.  Shares INVO closed at $.645 and is up +4.03% over the last 5-days and is up 52.12% YTD.  The 52-wk range is $.3290 – $3.55.
  • On Jan. 5, INVO Bioscience announced it has entered an exclusive distribution agreement with Ming Mei Technology Co. Ltd (“Ming Mei”) for Taiwan. The agreement will have an initial 1-year term with renewals. Ming Mei is a leading distributor of fertility-based devices and components in Taiwan helping to bring the latest and most advanced medical equipment into the region. Ming Mei estimates it has approximately 90% coverage of reagents and consumables in the reproductive medicine market in Taiwan. With strong customer relationships in the region, and their familiarity with the field of reproductive medicine, Ming Mei is ideally suited to expand distribution of INVOcell in Taiwan. Taiwan is a destination for assisted reproductive technology (ART) throughout Asia and also has the lowest birthrate in the world. Taiwan’s birth rate has dropped as a result of similar trends elsewhere in Asia, such as later marriage and increasing cost of living. Further, the average age of patients requiring therapy is rising. Fortunately, according to the statistics published by “ICMART”, the overall implantation rate of therapy in Taiwan ranked second worldwide, almost equal to the level in the U.S., and a leading country in Asia. The stable high success rate derives from updated medical research and enriched clinical experience from the physicians, advanced laboratory facilities and technology as well as patient-centered customized treatment plans (depending on their age, ovarian functions and causes of infertility, etc.). Prior to the pandemic, in 2019 there were approximately 55,000 ART cases in Taiwan, an increase of approximately 55% compared to 2016. In July 2021, the government in Taiwan implemented a subsidy plan for ART with the goal of encouraging more local married couples to undergo ART treatments. The subsidies are also available to transnational couples in which one spouse holds a Taiwanese ID card.



    • On Nov. 30, INVO announced the birth of the first baby in Malaysia utilizing the INVOcell solution. The healthy baby boy weighed 3.53 kg and was born on November 11, 2022 at Tuanku Mizan Military Hospital in Kuala Lumpur. Physicians at Advanced Reproductive Centre (ARC), at Hospital Canselor Tuanku Muhriz (HCTM), at the National University of Malaysia conducted the IVC procedure. The patient was part of a prospective peer reviewed study of INVOcell compared to conventional IVF (“cIVF”) that took place at ARC at HCTM. The study, titled “Comparison of Treatment Outcomes among Sibling Oocytes Using Different Culture Systems—Conventional IVF versus INVOcell Device—And Evaluation of INVOcell User Satisfaction: The INVOcIVF Study,” was published in the International Journal of Environmental Research and Public Health. “We couldn’t be more pleased to have been a part of this family’s journey towards parenthood,” commented Steve Shum, CEO of INVO Bioscience. “The INVOcell solution is playing a key role in providing families across the world an alternative method to parenthood by leveraging its innovative medical device to allow fertilization and early embryo development to take place in vivo within the woman’s body; an approach that provides for affordable, high-quality, patient-centered fertility care.” Key findings of the study included:

      • The fertilization rate and good embryo quality were comparable (not significantly different) between INVOcell and cIVF.
      • Although both methods produce similar fertilization rates and good-quality embryos, the blastulation rates were better in the INVOcell group.
      • INVOcell can be used as an alternative method for reproductive treatment in carefully selected patients without jeopardizing outcomes.
      • cIVF is costly and not applicable in most rural and district areas, therefore, the INVOcell can be utilized as a cost-effective alternative to cIVF without sacrificing comfort and outcomes.


    • On Nov. 10, Chinook provided a business update and reported financial results for the quarter and nine months ended September 30, 2022. “During the third quarter of 2022, we continued advancing our pipeline of clinical and preclinical programs for rare, severe chronic kidney diseases. We are pleased with the strong data presented at ASN Kidney Weekend 2022 from both our lead programs, atrasentan and BION-1301, in IgA nephropathy (IgAN), as well as from CHK-336 and our preclinical research approach,” said Eric Dobmeier, president and chief executive officer of Chinook Therapeutics. “We look forward to 2023, when we plan to initiate a phase 3 study of BION-1301 in patients with IgAN, present data from the ongoing phase 1 clinical trial of CHK-336 in healthy volunteers in the first half and report topline proteinuria data from the ongoing phase 3 ALIGN study of atrasentan in the third quarter.”



  • Borqs Technologies, Inc. (Nasdaq: BRQS, $.30 up a cool 44.23% YTD), a global provider of 5G wireless solutions, Internet of Things (IoT) solutions, and innovative clean energy, recently provided the following updates on the Company.
  • On Dec. 19, Borqs announced the Company has received a letter dated December 13, 2022 (the “Letter”) from the Department of the Treasury on behalf of the Committee on Foreign Investment in the United States (“CFIUS”) stating that the Company is required to negotiate with CFIUS to fully divest its ownership interests and rights in Holu Hou Energy LLC (“HHE”) due to HHE solar energy storage system and EnergyShare technology for Multi-Dwelling Residential Units (“MDU’s”) being deemed a critical technology and therefore a potential national security risk. As stated in the Letter, HHE is considered a top ten solar energy storage supplier in Hawaii, has only been increasing its dominant market share, expects to grow at an exponential rate, and focuses on multi-family dwelling units which are common in military housing. Due to Borqs’ IoT software development and hardware sourcing capabilities in China, CFIUS is concerned that through Borqs, the PRC could gain significant visibility and exert influence over HHE’s business operations and get access to HHE critical technology. CFIUS is requiring the Company to design a plan to mitigate all identified national security risks to the satisfaction of CFIUS. Borqs intends to comply to the requirements from CFIUS and enter into a National Security Agreement with various departments of the U.S. Government with a plan that is effective, monitorable and verifiable to voluntarily divest Borqs’ investment interests and rights in HHE (the “Plan”). HHE’s commercialization of its solar energy storage system and novel EnergyShare technology for MDU’s has enabled the company to open up a new market segment for renewable energy in the USA – likely worth several billions of dollars. In the last year the Company’s MDU development pipeline has reached thousands of individual units in Hawaii alone, with California MDU potential being at least one to two orders of magnitude higher in the coming years. One segment of this new market is for communities of military and other government personnel. The overall MDU opportunity is significant for the company and significant for the USA. Since Borqs’ financial support in HHE starting from October 2021, HHE has signed approximately $50 million in contracts and has a growing pipeline approaching half a billion dollars. They believe this voluntary mitigation will enable the tremendous inherent value of HHE to be realized and that the divestment can be a profitable transaction for Borqs’ shareholders. The Plan to mitigate will include engaging a nationally recognized investment bank with experience in administering competitive sales and auction processes, assigning and hiring of security and monitoring personnel to directly communicate with CFIUS, immediate and complete removal of all Borqs administrative and technical influence over HHE, immediate voluntary reduction of Borqs ownership of HHE from a majority to a minority position and with the target of divesting all. The Company believes such points will enable the Company to accomplish the divestment in an orderly manner.

  • On Dec.8, Borqs announced its subsidiary, Holu Hou Energy (HHE), has received multiple purchase orders for its HoluPower xP solar energy storage systems for installation at homeowner locations in the Greater San Diego area in California. These orders represent the first for the Company in California. Whereas in Hawaii HHE works to develop and construct Single-Family Residential projects as an “end to end” provider, the Company will target the California homeowner market through already existing channel partners that will sell and construct the projects. For Multi-Dwelling Unit (MDU) Residential properties in the State, the Company will initially target apartment owners, REITs and other MDU stakeholders directly, then partner with existing licensed contractors for system construction. HHE has been focused on the Hawaii market since it began commercial shipments in 2020, in order to become successfully established in the largest market in the United States based upon solar installation penetration. Now it is turning to California, the largest market in terms of size of available opportunity. HHE recently completed the testing and documentation required for the HoluPower xP to be listed as an approved product by the California Energy Commission. The Company expects to be listed by early January 2023, after which permitting and installations can commence. In Hawaii, Holu Hou Energy has quickly become a leader for solar energy storage systems in the Single-Family Residential market, and has essentially created the previously untapped Multi-Dwelling Unit (“MDU”) Residential market for renewable energy by virtue of its “EnergyShare” technology. The same leading product attributes will benefit MDU property owners and homeowners in California. The potential available MDU market in California is believed to be in the billions of dollars. EnergyShare enables networked systems to share excess generation behind their respective utility meters, a game-changer for improving the project economics for the MDU market, including for low-income housing, rental property units and Home Owners Association managed condominiums and town homes. EnergyShare enables more energy to be delivered to load, and fewer batteries to be installed than the standard approach of a unit-by-unit installation.
  • On Dec. 8, Borqs announced its subsidiary, Holu Hou Energy (HHE), has received multiple purchase orders for its HoluPower xP solar energy storage systems for installation at homeowner locations in the Greater San Diego area in California. These orders represent the first for the Company in California. Whereas in Hawaii HHE works to develop and construct Single-Family Residential projects as an “end to end” provider, the Company will target the California homeowner market through already existing channel partners that will sell and construct the projects. For Multi-Dwelling Unit (MDU) Residential properties in the State, the Company will initially target apartment owners, REITs and other MDU stakeholders directly, then partner with existing licensed contractors for system construction. HHE has been focused on the Hawaii market since it began commercial shipments in 2020, in order to become successfully established in the largest market in the United States based upon solar installation penetration. Now it is turning to California, the largest market in terms of size of available opportunity. HHE recently completed the testing and documentation required for the HoluPower xP to be listed as an approved product by the California Energy Commission. The Company expects to be listed by early January 2023, after which permitting and installations can commence. In Hawaii, Holu Hou Energy has quickly become a leader for solar energy storage systems in the Single-Family Residential market, and has essentially created the previously untapped Multi-Dwelling Unit (“MDU”) Residential market for renewable energy by virtue of its “EnergyShare” technology. The same leading product attributes will benefit MDU property owners and homeowners in California. The potential available MDU market in California is believed to be in the billions of dollars. EnergyShare enables networked systems to share excess generation behind their respective utility meters, a game-changer for improving the project economics for the MDU market, including for low-income housing, rental property units and Home Owners Association managed condominiums and town homes. EnergyShare enables more energy to be delivered to load, and fewer batteries to be installed than the standard approach of a unit-by-unit installation.



Shares of InMed Pharmaceuticals Inc. (INM), a leader in the research, development and manufacturing of rare cannabinoids, closed at $1.91.

  • On Jan. 10. InMed issued a press release that outlined their key accomplishments from 2022 and provided business update and catalysts for 2023 including the following interesting milestones for 2023: Complete Phase 2 clinical trial enrollment in Epidermolysis Bullosa in 1Q 2023, Progress preclinical research in glaucoma in preparation for human trials, & Advance research using rare cannabinoids in treating neurodegenerative diseases such as Alzheimer’s, Huntington’s and Parkinson’s. Please read our latest PROGRESS REPORT by clicking here.

  • On Dec. 16, InMed confirmed that, at its annual general meeting of shareholders held on December 15, 2022 (the “Meeting”), all of the matters put forward before shareholders for consideration and approval as set out in InMed’s notice of meeting and management information circular, dated October 28, 2022, were approved by the shareholders. In particular, shareholders approved the election of all director nominees to hold office until the next annual meeting of shareholders or until their successors are elected or appointed. See results. 
  • On Dec. 12, InMed announced the Company has entered into a service contract with Brio Financial Group to provide senior financial leadership and bookkeeping services. Pursuant to the Contract, Mr. Jonathan Tegge, a member of Brio, will assume the role of Interim Chief Financial Officer for the Company effective December 12, 2022. Brio is a financial and management consulting group based in Bridgewater, New Jersey. The firm provides outsourced financial management and financial reporting support to small and middle market entities. Currently, the team provides consulting services to over 50 private and publicly traded companies. Additionally, the Company announces that its auditor, KPMG, has resigned effective as of December 8, 2022, and that the Audit Committee of the Board of Directors of the Company approved the engagement of Marcum LLP  as its auditor, subject to Marcum’s completion of their client acceptance procedures. Marcum will stand for appointment at the Company’s Annual General Meeting, currently scheduled for Thursday, December 15, 2022. KPMG has confirmed that there are no reportable events (as such term is defined in National Instrument 51-102 – Continuous Disclosure Obligations (“NI 51-102”)).






Cytovia Therapeutics aims to accelerate patient access to transformational cell therapies and immunotherapies, addressing several of the most challenging unmet medical needs in cancer. Cytovia focuses on harnessing the innate immune system by developing complementary and disruptive iPSC-derived Natural Killer (iNK) cell and Flex-NK™ bispecific antibody platforms. The company is developing three types of iNK cells: unedited iNK cells, TALEN® gene-edited iNK cells with improved function and persistence, and TALEN® gene-edited iNK cells with chimeric antigen receptors (CAR-iNKs) to improve tumor-specific targeting. The second complementary cornerstone technology is a quadrivalent multifunctional antibody platform designed to engage natural killer cells by targeting NKp46 using Cytovia’s proprietary Flex-NK™ technology. These two technology platforms are being used to develop treatment for patients with solid tumors such as HCC and glioblastoma as well as hematological malignancies such as refractory multiple myeloma. Headquartered in Aventura, FL., Cytovia has research and development laboratories in Natick, MA. The company’s own R&D work is augmented through scientific partnerships with Cellectis, CytoImmune, the Hebrew University of Jerusalem, INSERM, the New York Stem Cell Foundation, the National Cancer Institute, and the University of California San Francisco (UCSF). Cytovia has a partnership with CytoLynx Therapeutics focused on research and development, manufacturing, and commercialization activities in Greater China.

On Dec. 9, 2022, Cytovia announced new preclinical data for its CD38-targeted Flex-NK™ bispecific antibody at the American Society of Hematology’s 64th Annual Meeting (ASH 2022) taking place in New Orleans, LA, and virtually December 10-13th, 2022. “We’re delighted to see further progress on our CD38-targeted Flex-NK™ bispecific antibody program, with a pre-clinical package that supports clinical evaluation in 2023,” commented Cytovia CEO Dr. Daniel Teper. “The data presented at ASH suggests that CYT-338, our CD38-targeted Flex-NK™ Bispecific Antibody, has a differentiated profile compared to daratumumab, the leading CD38-targeted monoclonal antibody and that CYT-338 may have the ability to overcome NK cell exhaustion and dysfunction.”  Cytovia believes that by redirecting and activating NK cells to kill myeloma cells, bispecific antibodies have the potential to offer new options for patients not responding to first lines of treatment.”


Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again this year!

Investing & Inspiration

  1. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
  2. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
  3. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
  4. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
  5. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  6. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  7. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
  8. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
  9. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  10. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
  11. “No man was ever wise by chance.” – Lucius Annaeus Seneca
  12. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  13. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  14. “It does not matter how slowly you go as long as you do not stop.” – Confucius

  15. “I want to put a ding in the universe.” – Steve Jobs

  16. “Research is creating new knowledge.” – Neil Armstrong

  17. “The reward for work well done is the opportunity to do more.” – Jonas Salk
  18. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
  19. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey
  20. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

  21. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger
  22. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

  23. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

  24. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain
  25. “The best way out is always through.” – Robert Frost

  26. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi
  27. “Without labor nothing prospers.” – Sophocles

  28. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein
  29. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

  30. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

  31. “He who is brave is free.” – Lucius Annaeus Seneca
  32. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

  33. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

  34. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

  35. “He who knows that enough is enough will always have enough.” – Lao Tzu

  36. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall
  37. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

  38. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
  39. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  40. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
  41. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
  42. “You must do the things you think you cannot do.”- Eleanor Roosevelt
  43. “Success is dependent on effort.” – Sophocles
  44. “Nobody who ever gave his best regretted it.” – George Halas
  45. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
  46. “And when I breathed, my breath was lightning.” – Black Elk
  47. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
  48. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
  49. “If you want a guarantee, buy a toaster.” – Clint Eastwood
  50. “We are an impossibility in an impossible universe.” – Ray Bradbury
  51. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
  52. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
  53. Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
  54. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
  55. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
  56. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
  57. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
  58. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
  59. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
  60. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
  61. “There is more to life than increasing its speed.” – Mahatma Gandhi
  62. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
  63. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
  64. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
  65. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
  66. “Life is too short for long-term grudges.” – Elon Musk
  67. There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
  68. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
  69. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
  70. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
  71. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
  72. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
  73. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
  74. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  75. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
  76. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  77. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
  78. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  79. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
  80. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
  81. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
  82. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
  83. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
  84. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
  85. “Delete the negative; accentuate the positive!” – Donna Karan
  86. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
  87. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
  88. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
  89. “Everything has beauty, but not everyone sees it.” – Confucius
  90. A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
  91. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
  92. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
  93. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  94. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  95. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
  96. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  97. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
  98. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  99. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
  100. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
  101. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
  102. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
  103. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
  104. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  105. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
  106. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
  107. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
  108. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  109. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  110. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
  111. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
  112. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
  113. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
  114. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
  115. “Never do anything against conscience even if the state demands it.”– Albert Einstein
  116. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  117. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
  118. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  119. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  120. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
  121. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
  122. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
  123. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
  124. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
  125. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
  126. “The secret of getting ahead is getting started.” – Mark Twain
  127. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe

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