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Nasdaq Ticks Higher As The Fed Hikes Interest Rates – $AAPL $ATOS $BRQS $IMGN $IMN $INVO $KVUE $LLY $TSLA $XBI Rise!

By John F. Heerdink, Jr.


Quote of the Day:  “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson


Happy Saturday!

I hope that you had a wonderful week and successful grew your investment accounts. 

As for the broad markets this week, the markets bacame a bit more volatile this week as the banking crisis paced up pace. In fact, The CBOE Volatility Index (^VIX) closed at $17.19, +8.94% over the last 5-days. US Banks once again added more pressure and worries in the markets again after First Republic Bank had to be bailed out early in the week by JPM and then the Fed proceeded to raise interest rates placing additional strain on the banking system and fear in investors’ minds. Shares of PacWest (PACW, $5.76, -43% over the last 5-days) & Western Alliance (WAL, $27.16, -26.83%) also took a nosedive as both are reportedly considering strategic alternatives and may be falling next. In turn, the SPDR S&P Regional Banking ETF (KRE) dropped a meaty 10.10% over the last 5-days to close at $38.35 & the SPDR S&P Bank ETF (KBE) dropped 8.14% over the last 5-days to close at $33.65. 

Numerous macroeconomic reports surfaced once again this week. On Monday, the Final April IHS Markit Manufacturing PMI report came in slightly lower at 50.2, while the March Construction Spending report ticked up to .3%. The April ISM Manufacturing Index report also came in below the medusa line at 47.1% confirming further contraction. On Tuesday, a couple of macroeconomic reports surfaced including the March Factory Orders report that came in lower than expected at .9% & the March JOLTS or Job Openings report came in at 9.590M. On Wednesday, the Fed made their expected move to raise interest rates by 25bps again. Curiously, the yield curve moved lower this week as the 2-yr yield dropped 15bps to 3.91% & the 10-yr note yield closed flat at 3.45%. The U.S. Dollar Index moved down .4% to close 101.24. The ADP Employment Change report confirmed a 296k rise in April. The final IHS Markit Services PMI report for April ticked lower to 53.6, while the ISM Non-Manufacturing Index report for April moved up to 51.9% and above the expansion line. The weekly EIA Crude Oil Inventories report came in with a 1.28M barrel draw. On Thursday, the Q1 Preliminary Productivity report came in at -2.7%, while the Q1 Preliminary Unit Labor Cost report came in at 6.3%. The March Trade Balance report clocked at -$64.2B. The Weekly Initial Claims report came in at 242k, while the Weekly Continuing Claims report cam in at 1.805 M. The weekly EIA Natural Gas Inventories report confirmed a 54 bcf build. On Friday, the Nonfarm payrolls report showed a 253k rise in April , while Nonfarm private payrolls moved 230k higher in April. The unemployment report showed that it ticked lower 3.4% in April. The average work week report clocked in flat in April at 34.4 hours, while it showed that the average hourly earnings rose by .5%. 


The S&P 500 closed at 4,136.25 (-.8%) for the week and is now up 7.7% YTD as only 3 of the 11 sectors closed in the green. The energy sector off 5.8% took the largest hit this week as oil prices fell a cool 7.15% to close at $71.36/bbl and is down 11.1% YTD. Not surprising the financials came in second place with a 2.7% drop, the communication services sector also took a solid hit of 2.3%. The 6.82% weighting of the shares of Apple (AAPL) closed at $173.57, +2.29% over the last 5-days as they announced their fiscal Q2 earnings beating Wall Street’s expectations on iPhone sales and also seeing revenues of $94.8B vs. $92.6B expected & Adj. EPS came at $1.52 versus $1.43 expected. EV giant Tesla (TSLA) closed at $170.06 rebounding 3.5% over the course of the week. 

The Dow 30 closed at 33,674.30 (-1.2%)  and is now up 1.6% YTD.  The Walt Disney Company (DIS) closed at $1000.52, -1.93% over the last 5-days as Disney continues its battle against Florida Governor Ron DeSantis. Nike (NKE) closed at $126.59, -.10% over the last 5-days.  

The Nasdaq closed at 12,235 (+.1%) and now up 16.9% YTD.  AMD ($89.84) and Microsoft (MSFT, $310.65) announced that they are working together in the AI race.

The small caps on the Russell 2000 closed at 1,759.88 (-.5%) for the week & is now down .1 YTD. The MicroCaps also moved solidly higher again this week as the iShares Micro-Cap ETF (IWC) closed at $102.11,+.59% this week & remains down 5.30% YTD.  

Biotech stocks moved higher overall this week. On the larger side of things, the Nasdaq Biotechnology ETF (IBB) closed at $131.921, +1.08% over the last 5-days and is +.48% YTD, the NYSE ARCA Biotech Index (^BTK) closed at 5,309.76, +.95% over the last 5-days and is now +.54% YTD, & the the lower side of the bother market the SPDR S&P Biotech ETF (XBI) closed at $85.38, up a very solid 6.46% over the last 5-days, & is +2.87% YTD. The 52-week range is is now $61.78-$95.18.  

Shares of ImmunoGen Inc. (Nasdaq: IMGN) moved higher this week to close at $13.17, +144.34% above the last 5-days. ImmunoGen is a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, and announced yesterday positive top-line data from the Phase 3 confirmatory MIRASOL trial (GOG 3045/ENGOT OV-55) evaluating the safety and efficacy of ELAHERE® (mirvetuximab soravtansine-gynx) compared to chemotherapy in patients with folate receptor alpha (FRα)-positive platinum-resistant ovarian cancer who have received one to three prior lines of therapy. Based on these data, the Company plans to submit a Marketing Authorization Application (MAA) in Europe and a supplemental Biologics License Application (sBLA) in the US for the conversion to a regular approval of ELAHERE. They also announced that it intends to offer and sell, subject to market and other conditions, $200 million of shares of its common stock in an underwritten public offering. ImmunoGen also intends to grant the underwriters a 30-day option to purchase up to an additional fifteen percent (15%) of the number of shares of common stock offered in the public offering at the public offering price, less underwriting discounts and commissions. All of the shares of common stock to be sold in the offering are to be offered by ImmunoGen. There can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering. ImmunoGen intends to use the net proceeds from this offering to fund its operations, including, but not limited to, global commercialization activities, supply of ELAHERE® (mirvetuximab soravtansine-gynx) drug product, clinical trial activities, pipeline research and development activities, business development activities, and capital expenditures. Jefferies, Goldman Sachs & Co. LLC, and Guggenheim Securities are acting as joint book-running managers for the proposed offering.

Eli Lilly and Company (NYSE: LLY, $427.81, +8.07% over the last 5-days) announced positive results of the TRAILBLAZER-ALZ 2 Phase 3 study showing that donanemab significantly slowed cognitive and functional decline in people with early symptomatic Alzheimer’s disease. Donanemab met the primary endpoint of change from baseline until 18 months on the integrated Alzheimer’s Disease Rating Scale (iADRS). The primary endpoint of iADRS measures cognition and activities of daily living such as managing finances, driving, engaging in hobbies, and conversing about current events. All secondary endpoints of cognitive and functional decline were also met and showed highly statistically significant clinical benefits with similar magnitude. Based on these results, Lilly will proceed with global regulatory submissions as quickly as possible and anticipates making a submission to the U.S. Food and Drug Administration (FDA) yet this quarter. Lilly will work with the FDA and other global regulators to achieve the fastest path to traditional approvals.

The iShares U.S. Healthcare ETF (IYH) closed at $281.284, +.23% over the last 5-days and is now down .66% YTD. Kenvue Inc. (KVUE), the world’s largest pure-play consumer health company by revenue & the new spinoff of Johnson & Johnson’s (JNJ, $162.13, -.45%) consumer brand segment, began trading on Thursday on the New York Stock Exchange in connection with its initial public offering. Chief Executive Officer and Director, Thibaut Mongon, and members of the Kenvue Leadership Team celebrated by ringing the Opening Bell. Kenvue’s IPO saw upsized pricing at $22/share & increased shares to 172.8 M that raised ~$3.8 giving it an approx. $45B valuation, KVUE shares rose to close at $26.50 on Friday. This still left J&J as the majority stakeholder with north of 90% of KVUE’s shares.

From the world of cryptocurrency, Bitcoin (BTC) managed to stay below the $30k level again this week, but moved up to $29,507.85 & up 5.04% over the course of the last 5-days at the time of the completion of this message. 

Further VP Watchlist Updates

  • The multi-billion-dollar global fertility market is predicted to reach approximately US$47.9 billion by 2030, yet remains severely underserved with many patients (upwards of 90% by many estimates) unable to access affordable treatment. INVO Bioscience, Inc. (NASDAQ: INVO) offers the INVOcell solution which provides an advanced, effective and affordable infertility treatment to help increase access to care. INVO is commercially advancing INVOcell through the opening of INVO Centers, opportunistically now pursuing acquisitions of established fertility (IVF) clinics in the U.S., and continuing to offer the technology to existing fertility practices.  Shares INVO closed at $.3735 up 3.75% over the last 5-days. The 52-wk range is $.3290 – $1.97.
  • On April 18, Maxim Group’s Analyst Jason McCarthy, Ph.D. issued a BUY rating on INVO Bioscience (INVO), a commercial-stage fertility company focused on expanding the assisted reproductive technology (ART) marketplace by making fertility care accessible and inclusive to people around the world. His report is titled, “4Q Results and Outlook: Fertility Space Remains Active as INVO Expands Strategy with IVF Clinic Acquisition.” His 12-month Price Target is $3. 

  • On April 17, INVO Bioscience announced financial results for the fourth quarter and fiscal year ended December 31, 2022 and provided a business update. Steve Shum, CEO of INVO stated, “2022 was another important year overall for INVO. Our initial three INVO centers made steady progress throughout their first full year of operation, reaching a combined total revenue of over $1.6 million, setting the stage for our plans to build additional INVO Centers with Tampa targeted to open soon. We further evolved our commercial efforts to build the Company by adding an acquisition strategy that is expected to allow us to synergistically introduce INVOcell into existing IVF clinics and to add profitable revenue sources to our operations. Additionally, we have made significant progress with our 5-day label enhancement efforts with the FDA. The signing of binding agreements to acquire Wisconsin Fertility Institute, an existing, established, profitable conventional IVF center is significant for a number of reasons, but most notably its ability to accelerate our business plan and substantially improve our financial profile. The acquisition approach is highly complementary to our ongoing efforts to build new INVO Centers and increase the distribution of INVOcell across existing IVF clinics. This multi-channel strategy greatly enhances our business and provides a solid foundation and strategy for our future growth.”

  • On April 5, INVO announced that it congratulates recently acquires Wisconsin Fertility Institute on being named one of America’s Best Fertility Clinics by Newsweek. During the survey period from November to December 2022, Newsweek and Statista invited over 3,000 reproductive endocrinologists, infertility specialists, obstetricians/gynecologists working in and referring patients to fertility clinics, other medical professionals (e.g., registered nurses, laboratory assistants) and fertility clinic administrators/managers working in fertility clinics to participate in the survey. Participants were asked to assess the quality in five categories for each recommended facility and to assign a ranking position to a set of fertility clinics. Only facilities defined as fertility clinics and ART (“Advanced Reproductive Technology”) providers by the Centers for Disease Control and Prevention (CDC) were considered. Click here for a full listing and methodology for inclusion.

  • On March 27, INVO Bioscience announced the closing of its previously announced registered direct offering of 3,680,000 shares of common stock (or pre-funded warrants in lieu thereof), priced at-the-market under Nasdaq rules. In a concurrent private placement, the Company also issued warrants to purchase up to an aggregate of 5,520,000 shares of common stock. The combined effective offering price for each share of common stock (or pre-funded warrant in lieu thereof) and warrant is $.815. The warrants are immediately exercisable, expire on the eight-year anniversary of the issuance date and have an exercise price of $0.63 per share. Maxim Group LLC is acting as the sole placement agent for the offering.

  • On Monday, March 20, INVO announced that they have signed binding agreements to acquire Wisconsin Fertility Institute, a materially transformative acquisition. The Madison-based fertility center primarily offers conventional IVF procedures and generated approximately $5.5 million in revenue and net income of approximately $1.9 million for the trailing 12-month period ended September 30, 2022. Wisconsin Fertility Institute is one of the state’s preeminent fertility centers, having helped to welcome over 5,000 babies since opening its doors in 2007 and with approximately 550 conventional IVF procedures completed in 2022. Wisconsin Fertility Institute is led by internationally renowned and well-respected fertility expert, Dr. Elizabeth Pritts, who will continue to serve as the clinic’s lead physician for a minimum period of three years from the closing of the acquisition. Dual-certified in General Obstetrics and Gynecology, as well as Reproductive Endocrinology and Infertility, Dr. Pritts completed a surgical fellowship in Advanced Gynecologic Laparoscopy and Hysteroscopy. She is also a national leader in the use of robotic surgery for gynecologic disorders. Dr. Pritts served as an assistant professor in reproductive endocrinology and infertility at the University of Wisconsin Medical School, as a clinical fellow at the University of California at San Francisco, and as an instructor at Yale University School of Medicine. She has authored more than 70 articles for scientific publications and has lectured throughout the world on reproduction and fertility. Read out latest Progress Report here. 

  • Borqs Technologies, Inc. (Nasdaq: BRQS, $.2172, up 3.43% over the last 5-days), a global provider of 5G wireless solutions, Internet of Things (IoT) solutions, and innovative clean energy, recently provided the following updates on the Company.
  • On April 26, Borqs Technologies published its Letter to Shareholders Regarding the Divestment of Solar Subsidiary. “Dear Shareholders of Borqs Technologies, Inc.: The purpose of this letter is to help clarify the proposed divestment of our company’s ownership in Holu Hou Energy, LLC (“HHE”) and the implications that this transaction may have to Borqs and our shareholders. Why the divestment? As we have stated in prior press releases, the Committee on Foreign Investment in the United States (“CFIUS”) has notified our company by a letter dated December 13, 2022, that CFIUS has identified risks to US national security arising as a result of Borqs’s investment in HHE. CFIUS advised us that the national security risks arising as a result of Borqs’s investment transaction with HHE relate to foreign proximity to U.S. military personnel and installations through HHE’s physical access to customers and their facilities, including at off-base military housing. CFIUS therefore required Borqs and HHE to enter into a National Security Agreement with CFIUS, pursuant to which Borqs must divest its interests in HHE. Proactive steps by Borqs. Read the balance here:” 
  • On April 20, Borqs announced that its subsidiary, Holu Hou Energy LLC (HHE), a provider of design-to-service solar plus energy storage systems, has signed a contract to install HHE’s HoluPower energy storage and solar photovoltaic (PV) systems on homes at Lendlease’s Island Palm Communities (IPC) in Honolulu, Hawaii. When completed, the project will be worth well into the nine figures in sales for HHE. Lendlease, a leading real estate and investment group that manages almost 8,000 homes for the U.S. Army on Oahu, is the purchaser of the electricity and the installations will come in the form of HHE’s EnergyCluster, where multiple residential units have their systems connected in an energy network or “cluster.” Excess solar generation from any unit’s system in the network that would normally be lost is directly shared in real time with other connected units that have load above solar generation. The benefit is that the optimized PV and energy storage systems can meet 75-80% or more of the overall residents’ energy needs while not exporting power to the utility grid. Lendlease and HHE began initial planning in 2021, which culminated in constructing a “pilot” project in May 2022. Since then, the pilot has been operating with outstanding results across six residential units. In a typical month, approximately a third of the total generated electricity is shared with other units in the “cluster” thereby solving issues related to vacancy and resident load variability, while proving out the superior value created through a clustered approach versus stand-alone systems. The savings realized by Island Palm Communities through deployment of HHE’s systems is being reinvested to enhance the housing and amenities Lendlease offers to military families on the installation. Additionally, residents now have resilient back-up power that can be utilized during grid outage events. These systems also take a load burden off the Oahu electric grid, which improves overall stability. Each residential unit will have approximately 10kW of PV and 25 kWh of energy storage, with six residences typically being connected in an HHE EnergyShare network. Construction is set to begin summer of 2023, with initial installations at the Aliamanu Military Reservation near Honolulu.
  • Shares of BRQS landed in the top ten Reddit Short Squeeze Mentions on Thursday, April 13.



Shares of InMed Pharmaceuticals Inc. (INM), a leader in the research, development and manufacturing of rare cannabinoids, closed at $1.23, up +2.50% over the last 5-days.

  • On March 28, InMed announced it has concluded enrollment of its Phase 2 clinical trial using investigational drug INM-755 cannabinol (“CBN”) cream for the treatment of patients with epidermolysis bullosa (“EB”), a rare genetic skin disease. The Phase 2 study, called INM-755-201-EB, enrolled 19 patients. All four subtypes of inherited EB, including EB Simplex, Dystrophic EB, Junctional EB, and Kindler Syndrome were accepted into the trial. The clinical trial is evaluating the safety of INM-755 cannabinol cream and its preliminary efficacy in treating symptoms of itch, pain, and wound healing in patients with epidermolysis bullosa. The study used a within-patient, double-blind design whereby matched index areas are randomized to INM-755 (cannabinol) cream or vehicle cream as a control. Results from this Phase 2 study of INM-755 CBN cream are expected to be released early calendar Q3 2023. “Enrollment completion of this Phase 2 clinical trial of a cannabinol formulation represents an important milestone for InMed and the scientific community studying rare cannabinoids,” said Eric A. Adams, InMed’s President and CEO. “As a class of compounds, we believe cannabinoids hold tremendous therapeutic potential for their innate interaction with the body, however, to date there have been limited evidence-based studies investigating their effects. Taking a rare cannabinoid formulation through several Ph 1 and Ph 2 clinical trials has been a major undertaking. We look forward to the data read-out in the summer, so we can evaluate our strategic options and next steps.”


Shares of Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need in oncology, with a current focus on breast cancer and radiation-induced lung injury, closed at $.6860,+7.19% over the last 5-days.



Atossa’s CEO, Steven Quay, M.D., Ph.D., presented at a Tribe Public even titled “Atossa Therapeutics (NASDAQ: ATOS) Redefining Breast Cancer Prevention and Treatment” on Thursday, May 4, 2023. Dr. Quay provided an update on the clinical development of Atossa’s proprietary Selective Estrogen Receptor Modulator (SERM), (Z)-endoxifen, which is currently being investigated in three separate Phase 2 studies. You may view the event at the following link at the Tribe Public YouTube Channel.


  • On March 22, Atossa announced financial results for the fiscal quarter and fiscal year ended December 31, 2022 and provided an update on recent company developments. Key developments from Q4 2022 and year to date included the Initiation and First Patient Dosed in Phase 2 EVANGELINE Study – EVANGELINE (Endoxifen Versus exemestANe GosEreLIn), is our Phase 2 randomized non-inferiority study of (Z)-endoxifen compared to exemestane plus goserelin as a neoadjuvant treatment for premenopausal women with Grade 1 or 2 ER+ / HER2- breast cancer. Participants receive neoadjuvant treatment for up to six months, followed by surgery. Several FDA-approved neoadjuvant therapies exist for ER- breast cancers, but few exist for ER+ patients, which account for approximately 78% of breast cancers. We expect to enroll approximately 175 patients at up to 25 sites across the United States. READ MORE.

 


    • On April 13, Chinook announced the appointment of Robert W. Azelby to its Board of Directors. Mr. Azelby brings more than 20 years of executive leadership and commercial experience in the biopharmaceutical industry to Chinook. “We are thrilled to welcome Bob to Chinook’s board of directors as we advance our pipeline through key milestones in 2023 and beyond,” said Eric Dobmeier, president and chief executive officer of Chinook Therapeutics. “Bob brings significant industry experience in building and growing companies and commercially launching new therapies, including in nephrology. His strategic counsel will be invaluable as we continue to advance treatments for patients with rare, severe chronic kidney diseases.” Mr. Azelby has more than two decades of experience leading biotech companies through key periods of development. Most recently, he served as president and chief executive officer of Eliem Therapeutics, a biotechnology company focused on developing novel therapies for neurology disorders, where he led the company through early growth with a $190 million in financing and a successful IPO. Previously, he served as the president and chief executive officer and a member of the board of directors of Alder BioPharmaceuticals, Inc. where he negotiated the successful sale of the company to Lundbeck. Prior to that, Mr. Azelby served as executive vice president and chief commercial officer of Juno Therapeutics through its acquisition by Celgene, and spent 15 years at Amgen in commercial roles across their nephrology and oncology business units. Mr. Azelby currently serves on the board of Clovis Oncology. He holds an M.B.A. from Harvard Business School and a B.A. in Economics and Religious Studies from the University of Virginia.

    • On March 23, Chinook announced presentations at the ISN World Congress of Nephrology 2023 from March 30 – April 2, 2023 in Bangkok, Thailand.



Cytovia Therapeutics aims to accelerate patient access to transformational cell therapies and immunotherapies, addressing several of the most challenging unmet medical needs in cancer. Cytovia focuses on harnessing the innate immune system by developing complementary and disruptive iPSC-derived Natural Killer (iNK) cell and Flex-NK™ bispecific antibody platforms. The company is developing three types of iNK cells: unedited iNK cells, TALEN® gene-edited iNK cells with improved function and persistence, and TALEN® gene-edited iNK cells with chimeric antigen receptors (CAR-iNKs) to improve tumor-specific targeting. The second complementary cornerstone technology is a quadrivalent multifunctional antibody platform designed to engage natural killer cells by targeting NKp46 using Cytovia’s proprietary Flex-NK™ technology. These two technology platforms are being used to develop treatment for patients with solid tumors such as HCC and glioblastoma as well as hematological malignancies such as refractory multiple myeloma. Headquartered in Aventura, FL., Cytovia has research and development laboratories in Natick, MA. The company’s own R&D work is augmented through scientific partnerships with Cellectis, CytoImmune, the Hebrew University of Jerusalem, INSERM, the New York Stem Cell Foundation, the National Cancer Institute, and the University of California San Francisco (UCSF). Cytovia has a partnership with CytoLynx Therapeutics focused on research and development, manufacturing, and commercialization activities in Greater China.

On Dec. 9, 2022, Cytovia announced new preclinical data for its CD38-targeted Flex-NK™ bispecific antibody at the American Society of Hematology’s 64th Annual Meeting (ASH 2022) taking place in New Orleans, LA, and virtually December 10-13th, 2022. “We’re delighted to see further progress on our CD38-targeted Flex-NK™ bispecific antibody program, with a pre-clinical package that supports clinical evaluation in 2023,” commented Cytovia CEO Dr. Daniel Teper. “The data presented at ASH suggests that CYT-338, our CD38-targeted Flex-NK™ Bispecific Antibody, has a differentiated profile compared to daratumumab, the leading CD38-targeted monoclonal antibody and that CYT-338 may have the ability to overcome NK cell exhaustion and dysfunction.”  Cytovia believes that by redirecting and activating NK cells to kill myeloma cells, bispecific antibodies have the potential to offer new options for patients not responding to first lines of treatment.”


Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again this year!

Investing & Inspiration

  1. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
  2. “Action is the foundational key to all success.” – Pablo Picasso
  3. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
  4. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
  5. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
  6. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
  7. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
  8. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
  9. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
  10. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
  11. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
  12. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
  13. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  14. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
  15. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
  16. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
  17. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
  18. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
  19. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  20. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  21. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
  22. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
  23. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  24. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
  25. “No man was ever wise by chance.” – Lucius Annaeus Seneca
  26. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  27. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  28. “It does not matter how slowly you go as long as you do not stop.” – Confucius

  29. “I want to put a ding in the universe.” – Steve Jobs

  30. “Research is creating new knowledge.” – Neil Armstrong

  31. “The reward for work well done is the opportunity to do more.” – Jonas Salk
  32. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
  33. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey
  34. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

  35. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger
  36. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

  37. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

  38. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain
  39. “The best way out is always through.” – Robert Frost

  40. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi
  41. “Without labor nothing prospers.” – Sophocles

  42. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein
  43. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

  44. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

  45. “He who is brave is free.” – Lucius Annaeus Seneca
  46. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

  47. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

  48. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

  49. “He who knows that enough is enough will always have enough.” – Lao Tzu

  50. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall
  51. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

  52. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
  53. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  54. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
  55. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
  56. “You must do the things you think you cannot do.”- Eleanor Roosevelt
  57. “Success is dependent on effort.” – Sophocles
  58. “Nobody who ever gave his best regretted it.” – George Halas
  59. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
  60. “And when I breathed, my breath was lightning.” – Black Elk
  61. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
  62. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
  63. “If you want a guarantee, buy a toaster.” – Clint Eastwood
  64. “We are an impossibility in an impossible universe.” – Ray Bradbury
  65. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
  66. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
  67. Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
  68. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
  69. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
  70. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
  71. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
  72. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
  73. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
  74. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
  75. “There is more to life than increasing its speed.” – Mahatma Gandhi
  76. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
  77. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
  78. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
  79. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
  80. “Life is too short for long-term grudges.” – Elon Musk
  81. There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
  82. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
  83. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
  84. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
  85. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
  86. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
  87. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
  88. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  89. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
  90. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  91. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
  92. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  93. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
  94. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
  95. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
  96. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
  97. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
  98. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
  99. “Delete the negative; accentuate the positive!” – Donna Karan
  100. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
  101. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
  102. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
  103. “Everything has beauty, but not everyone sees it.” – Confucius
  104. A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
  105. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
  106. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
  107. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  108. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  109. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
  110. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  111. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
  112. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  113. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
  114. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
  115. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
  116. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
  117. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
  118. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  119. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
  120. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
  121. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
  122. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  123. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  124. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
  125. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
  126. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
  127. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
  128. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
  129. “Never do anything against conscience even if the state demands it.”– Albert Einstein
  130. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  131. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
  132. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  133. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  134. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
  135. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
  136. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
  137. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
  138. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
  139. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
  140. “The secret of getting ahead is getting started.” – Mark Twain
  141. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe

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