Roaring Kitty Surfaces While Large Caps & AI Stocks Move Higher This Week – $ADT $AMZN $AAPL $GME $MSFT $NVDA $XBI Rise!

Happy Saturday!

I hope that you had a wonderful week & that it proved to be profitable one as well. As for me, I spent the week traveling to and from Nashville and Boston meeting with a number of CEO’s and investors at our sister firm Tribe Public (www.tribepublic.com)  CEO Presentation and Q&A Luncheon and Dinner Events and continued to gain great insights across the board via this direct corporate access platform.  I will be back to Nashville to co-host with Panna Sharma of Lantern Pharma (LTRN) on Wednesday, June 12. Please let me know if you would like to join either the luncheon event or the dinner event that day. 

As for the broad stock market this week, large equities overall trended higher, while the small came under pressure. Interestingly, one of the stories of the week came from memes stock world and particularly from GamesStop (GME, $28.22, +21.95% ver the last 5-days) and Keith Gill’s righteous return to YouTube. However, on Friday GameStop posted an adjusted loss of $.12/sh missing estimates & Net sales fell 29% to $882M.

This week’s US macroeconomic schedule offered a number of reports that keep the inflation story alive. On Monday, the Final May S&P Global US Manufacturing PMI report came in higher at 51.3 & the May ISM Manufacturing Index report that clocked in lower than expected at 48.7% showing significant contraction. The April Construction Spending report came in lower than expected at -.1%. On Tuesday, the April Factory Orders report came in slightly higher than expected at .7% & the April JOLTS report came in lower at 8.059M. On Wednesday, the Weekly MBA Mortgage Applications Index report confirmed a 5.2% drop, while the May ADP Employment Change report came in lower at 152k. The Final May S&P Global US Services PMI report came in higher at 54.8, while the May ISM Non-Manufacturing Index report also increased  to 53.8%. On Thursday, the Weekly Initial Claims report clocked higher than expected at 229k, while the Weekly Continuing Claims ticked higher to 1.792M as the jobs market may just be showing some cracks. The Q1 Productivity clocked in below expectations at .2%, while Q1 Unit Labor Costs came in lower than expected at 4.0%. The April Trade Balance report came in at -$74.6. On Friday, the May Nonfarm Payrolls report clocked in at 272k & May Nonfarm Private Payrolls was at 229k. The average May Hourly Earnings report came in at .4% & the May Unemployment Rate was 4% and the May Average Workweek was at 34.3. The April Wholesale Inventories report was at .1%.

Over the course of the week, the yield curve pulled back this week with the 10-yr note yield closing down 8bps at 4.43% & the 2-yr note yield moving down by 2bps to 4.87%.

Oil prices closed at $75.25/bbl, -.7% now up 5% YTD & the U.S. Dollar Index moved lower this week from 104.63 to 104.94.

The CBOE Volatility Index (^VIX) fell again over the course of the week down -6.79% to close at $12.22.

At the end of the week, the Dow 30 closed at 38,798.99 (+.3%) this week and is up +2.9% YTD. 

The S&P 500 closed at 5,346.99 (+1.3%) and is now up 12.1% YTD.

The Nasdaq closed at 16,735.02 (+2.4%) and is now up 14.1% YTD. The Magnificent 7 closed across the board as follows over the last 5-days: Alphabet (GOOG) closing at $175.96, +1.14%, Amazon (AMZN) closing at $184.30, +4.45%, Apple (AAPL) at $196.89, +2.41%, Meta Platforms (META) closing at $492.96, +5.60%, Microsoft (MSFT) closing at $423.85, +2.10%, NVIDIA (NVDA) closing at $1,208.88, +10.27%, & Tesla (TSLA) closing at $177.48, -.34%. 

The small caps on the Russell 2000 closed at 2,026.55 (-2.1%) for the week & is now up 0.0% YTD, while the MicroCaps closed higher this week as the iShares Micro-Cap ETF (IWC) closed at $113.95, -3.02% over the week.

Bank stocks on The SPDR S&P Regional Banking ETF (KRE) moved down to close at $47.21, -3.38% over the last 5-days & the SPDR S&P Bank ETF (KBE) moved down over the last 5-days to close at $45.03, -2.60% this week.  

Overall, The Nasdaq Biotechnology ETF (IBB) closed at $136.72, +2.12% & the SPDR S&P Biotech ETF (XBI) closed at $91.39, +2.54% over the last 5-days. The iShares U.S. Healthcare ETF (IYH) closed at $61.31, +1.79% over the last 5-days. 

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $43.80, +3.18% over the last 5-days.

From the world of cryptocurrency, Bitcoin (BTC) moved from $67,582.92 to 69,378.74 over the course of the last 5-days at the time of the completion of this message.

Gold prices closed at $2,297/.oz down from $2,330/.oz over the last 5-days. Silver prices closed at $29.20/.oz down from $30.42/oz. 

VP Watchlist Updates

 

Modular Medical, Inc. (NASDAQ: MODD, $1.585, -2.76% over the last 5-days), is a development-stage medical device company that intends to launch the next generation of insulin delivery technology. Using its patented technologies, the company seeks to eliminate the tradeoff between complexity and efficacy, thereby making top quality insulin delivery both affordable and simple to learn. Their mission is to improve access to the highest standard of glycemic control for people with diabetes taking it beyond “superusers” and providing “diabetes care for the rest of us.” Modular Medical was founded by Paul DiPerna, a seasoned medical device professional and microfluidics engineer. Prior to founding Modular Medical, Mr. DiPerna was the founder (in 2005) of Tandem Diabetes and invented and designed its t:slim insulin pump. More information is available at https://modular-medical.com.

 

 

On March 6, Modular Medical’s CEO Jeb Besser presented at Tribe Public’s Webinar Presentation and Q&A Event titled “Revolutionizing Diabetes Care.”  You may view the event video now to learn more by clicking this link.

Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP), a clinical stage biotechnology company dedicated to pioneering innovative cancer and viral infection treatments, closed at  $2.65, +11.81% over the last 5-days and is up 50.57% YTD. Click to watch a brief video on Indaptus Therapeutics’ Decoy20 Cancer Treatment Approach.

On June 4, Indaptus announced that it will present a poster titled, “Preliminary results of a phase 1 study of Decoy20, an intravenous, killed, multiple immune receptor agonist bacterial product in patients with advanced solid tumors,” at the American Society of Clinical Oncology annual meeting on June 1, 2024, in Chicago.

On May 22, Indaptus announced the successful advancement of its Phase 1 trial for Decoy20, an investigational novel package of broad immune agonists for cancer immunotherapy that has first-in-class potential across a diverse range of cancers including liver, pancreatic, colorectal and non-small cell lung. Following review by a Safety Review Committee (SRC) of the company’s initial clinical data, which will be presented at the annual meeting of the American Society of Clinical Oncology (ASCO), the Company has successfully dosed the first patient in the multi-dose portion of the trial with Decoy20. The primary goal of this stage of the trial is to determine the safety of Decoy20 when administered multiple times to the same patient, and to begin to examine efficacy across multiple types of cancer. Decoy20 is composed of attenuated and killed, intact, non-pathogenic Gram-negative bacteria which are designed to act as a “decoy,” tricking the body into activating a broad antitumor response from both its innate and adaptive immune systems. In preclinical studies, the treatment has been shown to activate specialized immune receptors called TLRs, that facilitate a potent defense against tumors, without inducing excessive toxicity. The product candidate is designed to induce a strong and broad pulse of immune activation, followed by rapid clearance from the body.“Current immunotherapies usually target a few immune system pathways and have low cure rates in advanced cancers. Indaptus is investigating an incredibly exciting and differentiated approach to fighting cancerous tumors that deviates from a focus on targeted therapies in the field. The advancement of this trial is a significant milestone that builds on strong evidence that Decoy20 successfully and broadly activates potent tumor-fighting cytokines and chemokines in both the innate and adaptive immune systems, and was administered systemically without intolerable adverse events,”stated Roger Waltzman, MD, Chief Medical Officer of Indaptus.

On May 8, Indaptus announced financial results for the first quarter ended March 31, 2024, and provided a corporate update. 

 

Jeffrey Meckler, CEO, Indaptus Therapuetics, Inc. (NASDAQ: INDP)

Jeffrey Meckler, Chief Executive Officer of Indaptus, commented, “We continue to make steady progress in our clinical development plans and are receiving regular validation for results reported to date, both through a presentation in April at the American Association for Cancer Research (AACR) annual meeting, and the acceptance of further data to be presented in a poster at the American Society of Clinical Oncology (ASCO) annual meeting, which is considered among the top annual oncology conferences. We are encouraged by the results we have reported, along with the early results we are seeing as we advance our trial, and believe they are indicative of the potential for Decoy20, and indeed our platform as a whole. We look forward to reporting more about our progress as it develops.”

On April 11, Indaptus announced it was proud to unveil its poster at the 2024 Annual Meeting of the American Association for Cancer Research (AACR) in San Diego on Wednesday, April 10th. The poster details mechanism of action data that demonstrates the Company’s Decoy platform successfully induces, matures or activates multiple immune cell types involved in anti-tumor responses. The latest findings significantly enhance the Company’s understanding of its “Decoy” platform technology, which uses killed, non-pathogenic bacteria engineered to activate the immune system to attack tumors. The study highlights the platform’s effectiveness in engaging key innate and adaptive immune cells, including, natural killer cells, natural killer T cells, dendritic cells, CD4+, and CD8+ T cells. In some settings, the platform also produced additive or synergistic activity in combination with IL-2, an approved cancer drug. Additionally, the data reveal that the Decoy platform may not only boost the immune system’s ability to recognize and kill tumor cells, but potentially also overcome a mechanism that suppresses the immune response. The results suggest that the Company’s Decoy bacteria can both directly and indirectly prime the immune system to more effectively fight cancer. Jeffrey Meckler, Indaptus’ Chief Executive Officer, added, “We are encouraged by the promising results observed in our preclinical studies and our ongoing Phase 1 clinical trial. The recognition and validation from prestigious organizations such as the AACR, coupled with the support and insights we are receiving from medical experts, partners and investors at the conference, inspire us to continue advancing our technology and demonstrating its significant therapeutic potential for the treatment of solid tumors.” The full poster can be accessed on the Indaptus Therapeutics website by clicking here.

Dr. Michael Newman, Indaptus’ Founder, Chief Scientific Officer, and lead author, commented, “The new data are consistent with our preclinical animal tumor model studies and provide evidence for our hypothesis that patented Decoy bacteria can activate a wide range of innate and adaptive human immune cells involved in fighting tumors. This aligns with what we’ve observed in our ongoing Phase 1 clinical trial of Decoy20 – broad immune activation, as evidenced by transiently increased levels of many key cytokines and chemokines following single dose administration. These findings bolster our confidence in Decoy20’s potential as a multifaceted immunotherapy.”

Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again as we move forward!

Investing & Inspiration

1. “There are no shortcuts in evolution.” – Louis D. Brandeis
2. “A friend may well be reckoned the masterpiece of nature.” –  Ralph Waldo Emerson
3. “Nature uses as little as possible of anything.” – Johannes Kepler
4. “Every new beginning comes from some other beginning’s end.” – Seneca
5. “Nothing ever becomes real till it is experienced.” – John Keats
6. “Nobody who ever gave his best regretted it.” – George Halas
7. “Honest disagreement is often a good sign of progress.” – Mahatma Gandhi
8. “A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell
9. “They always say time changes things, but you actually have to change them yourself.” – Andy Warhol
10. “The secret of happiness is something to do.” – John Burroughs
11. “The world of reality has its limits; the world of imagination is boundless.”
12. “You begin with the possibilities of the material.” – Robert Rauschenberg
13. “The only Zen you can find on the tops of mountains is the Zen you bring up there.” – Robert M. Pirsig
14. “Leadership is the capacity to translate vision into reality.” – Warren Bennis
15. “A man should always consider how much he has more than he wants.” – Joseph Addison
16. “Happiness is good health and a bad memory.” –  Ingrid Bergman
17. “We pass through this world but once.” – Stephen Jay Gould
18. “Christmas waves a magic wand over this world, and behold, everything is softer and more beautiful.” – Norman Vincent Peale
19. “Nothing can have value without being an object of utility.” – Karl Marx
20. “Always turn a negative situation into a positive situation.” – Michael Jordan
21. “Courage is found in unlikely places.” – J. R. R. Tolkien
22. “One that would have the fruit must climb the tree.” – Thomas Fuller
23. “Someone is sitting in the shade today because someone planted a tree a long time ago.” – Warren Buffett
24. “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes
25. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” – George Bernard Shaw
26. “Everything in the world may be endured except continual prosperity.”  – Johann Wolfgang von Goethe
27. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
28. “Time is money.” – Benjamin Franklin
29. “Change before you have to.” – Jack Welch
30. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
31. “The Universe is under no obligation to make sense to you.” – Neil deGrasse Tyson
32. “Care and diligence bring luck.” – Thomas Fuller
33. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
34. “A man who is a master of patience is master of everything else.” – George Savile
35. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
36. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
37. “Act as if what you do makes a difference. It does.” – William James
38. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
39. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
40. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
41. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
42. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
43. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
44. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
45. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
46. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
47. “Action is the foundational key to all success.” – Pablo Picasso
48. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
49. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
50. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
51. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
52. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
53. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
54. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
55. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
56. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
57. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
58. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
59. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
60. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
61. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
62. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
63. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
64. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
65. “There is little that can withstand a man who can conquer himself.” – Louis XIV
66. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
67. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
68. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
69. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
70. “No man was ever wise by chance.” – Lucius Annaeus Seneca
71. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
72. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare

73. “It does not matter how slowly you go as long as you do not stop.” – Confucius

74. “I want to put a ding in the universe.” – Steve Jobs

75. “Research is creating new knowledge.” – Neil Armstrong

76. “The reward for work well done is the opportunity to do more.” – Jonas Salk
77. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
78. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey

79. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

80. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger

81. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

82. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

83. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain

84. “The best way out is always through.” – Robert Frost

85. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi

86. “Without labor nothing prospers.” – Sophocles

87. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein

88. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

89. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

90. “He who is brave is free.” – Lucius Annaeus Seneca

91. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

92. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

93. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

94. “He who knows that enough is enough will always have enough.” – Lao Tzu

95. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall

96. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

97. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
98. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
99. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
100. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
101. “You must do the things you think you cannot do.”- Eleanor Roosevelt
102. “Success is dependent on effort.” – Sophocles
103. “Nobody who ever gave his best regretted it.” – George Halas
104. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
105. “And when I breathed, my breath was lightning.” – Black Elk
106. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
107. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
108. “If you want a guarantee, buy a toaster.” – Clint Eastwood
109. “We are an impossibility in an impossible universe.” – Ray Bradbury
110. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
111. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
112. “Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
113. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
114. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
115. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
116. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
117. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
118. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
119. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
120. “There is more to life than increasing its speed.” – Mahatma Gandhi
121. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
122. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
123. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
124. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
125. “Life is too short for long-term grudges.” – Elon Musk
126. “There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
127. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
128. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
129. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
130. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
131. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
132. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
133. “Let there be work, bread, water and salt for all.” – Nelson Mandela
134. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
135. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
136. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
137. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
138. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
139. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
140. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
141. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
142. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
143. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
144. “Delete the negative; accentuate the positive!” – Donna Karan
145. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
146. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
147. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
148. “Everything has beauty, but not everyone sees it.” – Confucius
149. “A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
150. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
151. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
152. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
153. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
154. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
155. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
156. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
157. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
158. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
159. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
160. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
161. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
162. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
163. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
164. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
165. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
166. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
167. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
168. “There is little that can withstand a man who can conquer himself.” – Louis XIV
169. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
170. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
171. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
172. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
173. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
174. “Never do anything against conscience even if the state demands it.”– Albert Einstein
175. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
176. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
177. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
178. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
179. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
180. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
181. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
182. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
183. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
184. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
185. “The secret of getting ahead is getting started.” – Mark Twain
186. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe