Stock Market Ends May With A Bang – $AAPL $INDP $MODD $NVDA $SHIP $TSLA Rise!

Happy Saturday!

I hope that you experienced amazing success this week wherever the world landed you. I spent the balance of the holiday-shortened week getting back to nature in NorCal and specifically at Camp Taylor within the beautiful Samuel P. Taylor Park. If you have not been, then I highly suggest taking a break within its wonderful redwoods, trails, and tide pools. 

As for the broad stock market this week, equities overall trended and closed down over the course of the week, but near Friday’s closing bell we experienced a bit of a melt up and stocks flow up broadly into the close. Possibly an also or tow were triggered and or a few fund managers wanted to end the month on a high note.

This week’s US macroeconomic schedule offered a number of reports. On Tuesday, the March FHFA Housing Price Index report came in lower at .1% & the March S&P Case-Shiller Home Price Index report that came slighter higher than expected at 7.4%. The May Consumer Confidence report also showed a move higher to 102. On Wednesday, the weekly MBA Mortgage Applications Index report confirmed a sizable 5.7% drop as refinance applications plunged 14% & purchase applications fell by 1%. The Fed’s latest Beige Book stated that national economic activity continues to expand. On Thursday, the Advanced April International Trade in Goods report came in at -$99.4B, while the Advanced April Retail Inventories report clocked in higher at .7% & the Advanced April Wholesale Inventories report came in higher at .2%. Te Weekly Initial Claims clocked in as expected at 219k and the Weekly Continuing Claims came in slightly higher at 1.791M. The Q1 GDP (Second Estimate) came in s expected at 1.3% & the Q1 GDP Deflator (Second Estimate) clocked in slighter lower at 3% as some weakness in spending surfaced. The April Pending Home Sales report also confirmed a much larger than expected drop of -7.7%. On Friday, the April Personal Income came in lower, but in line at .3% and the April Personal Spending report came in at .2%, while the April PCE Prices cam in as expected at .3%. The May Chicago PMI report also came in lower than expected at 35.4.

Over the course of the week, the yield curve diverged this week with the 10-yr note yield closing up 4bps at 4.51% & the 2-yr note yield moving down by 6bps to 4.89%.

Oil prices closed at $77.719/bbl, -.7%, & are now up 7.7% YTD & the U.S. Dollar Index moved lower this week from 104.75 to 104.63.

The CBOE Volatility Index (^VIX) fell again over the course of the week down -0.0% to close at $12.92.

At the end of the week, the Dow 30 closed at 38,686.32 (-1%) this week and is up +2.6% YTD. 

The S&P 500 closed at 5,277.51 (-.5%) and is now up 10.6% YTD.

The Nasdaq closed at 16,735.02 (-1.1%) and is now up 11.5% YTD. The Magnificent 7 closed across the board as follows over the last 5-days: Alphabet (GOOG) closing at $173.96,-.63%, Amazon (AMZN) closing at $176.44, -2.55%, Apple (AAPL) at $192.25, +2.85%, Meta Platforms (META) closing at $466.83, +.23%, Microsoft (MSFT) closing at $415.13, -2.78%, NVIDIA (NVDA) closing at $1,096.33, +5.62%, & Tesla (TSLA) closing at $178.08, +2.50%. 

The small caps on the Russell 2000 closed at 2,070.13 (+0.0%)  for the week & is now up 2.1% YTD, while the MicroCaps closed higher this week as the iShares Micro-Cap ETF (IWC) closed at $117.50, +.77% over the week.

Bank stocks on The SPDR S&P Regional Banking ETF (KRE) moved up to close at $48.85, +.29% over the last 5-days & the SPDR S&P Bank ETF (KBE) moved up over the last 5-days to close at $46.23, +.65% this week.  

Overall, The Nasdaq Biotechnology ETF (IBB) closed at $133.88, -1.29% & the SPDR S&P Biotech ETF (XBI) closed at $89.13,-.21% over the last 5-days. The iShares U.S. Healthcare ETF (IYH) closed at $60.23, -.94% over the last 5-days. 

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $42.45, -2.66% over the last 5-days.

From the world of cryptocurrency, Bitcoin (BTC) moved from $68,843.33 to $67,582.92 over the course of the last 5-days at the time of the completion of this message.

Gold prices closed at $2,330/.oz down from $2,355/.oz over the last 5-days. Silver prices closed at $30.42.oz up from $30.36/oz. 

VP Watchlist Updates

 

Modular Medical, Inc. (NASDAQ: MODD, $1.63, +5.84% over the last 5-days and up +25.38% over the last 6-months), is a development-stage medical device company that intends to launch the next generation of insulin delivery technology. Using its patented technologies, the company seeks to eliminate the tradeoff between complexity and efficacy, thereby making top quality insulin delivery both affordable and simple to learn. Their mission is to improve access to the highest standard of glycemic control for people with diabetes taking it beyond “superusers” and providing “diabetes care for the rest of us.” Modular Medical was founded by Paul DiPerna, a seasoned medical device professional and microfluidics engineer. Prior to founding Modular Medical, Mr. DiPerna was the founder (in 2005) of Tandem Diabetes and invented and designed its t:slim insulin pump. More information is available at https://modular-medical.com.

 

 

On March 6, Modular Medical’s CEO Jeb Besser presented at Tribe Public’s Webinar Presentation and Q&A Event titled “Revolutionizing Diabetes Care.”  You may view the event video now to learn more by clicking this link.

Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP), a clinical stage biotechnology company dedicated to pioneering innovative cancer and viral infection treatments, closed at  $2.37, +.42% over the last 5-days and is up 34.66% YTD. Click to watch a brief video on Indaptus Therapeutics’ Decoy20 Cancer Treatment Approach.

Indaptus to present poster titled, “Preliminary results of a phase 1 study of Decoy20, an intravenous, killed, multiple immune receptor agonist bacterial product in patients with advanced solid tumors,” at the American Society of Clinical Oncology annual meeting on June 1, 2024, in Chicago.

On May 22, Indaptus announced the successful advancement of its Phase 1 trial for Decoy20, an investigational novel package of broad immune agonists for cancer immunotherapy that has first-in-class potential across a diverse range of cancers including liver, pancreatic, colorectal and non-small cell lung. Following review by a Safety Review Committee (SRC) of the company’s initial clinical data, which will be presented at the annual meeting of the American Society of Clinical Oncology (ASCO), the Company has successfully dosed the first patient in the multi-dose portion of the trial with Decoy20. The primary goal of this stage of the trial is to determine the safety of Decoy20 when administered multiple times to the same patient, and to begin to examine efficacy across multiple types of cancer. Decoy20 is composed of attenuated and killed, intact, non-pathogenic Gram-negative bacteria which are designed to act as a “decoy,” tricking the body into activating a broad antitumor response from both its innate and adaptive immune systems. In preclinical studies, the treatment has been shown to activate specialized immune receptors called TLRs, that facilitate a potent defense against tumors, without inducing excessive toxicity. The product candidate is designed to induce a strong and broad pulse of immune activation, followed by rapid clearance from the body.“Current immunotherapies usually target a few immune system pathways and have low cure rates in advanced cancers. Indaptus is investigating an incredibly exciting and differentiated approach to fighting cancerous tumors that deviates from a focus on targeted therapies in the field. The advancement of this trial is a significant milestone that builds on strong evidence that Decoy20 successfully and broadly activates potent tumor-fighting cytokines and chemokines in both the innate and adaptive immune systems, and was administered systemically without intolerable adverse events,”stated Roger Waltzman, MD, Chief Medical Officer of Indaptus.

On May 8, Indaptus announced financial results for the first quarter ended March 31, 2024, and provided a corporate update. 

 

Jeffrey Meckler, CEO, Indaptus Therapuetics, Inc. (NASDAQ: INDP)

Jeffrey Meckler, Chief Executive Officer of Indaptus, commented, “We continue to make steady progress in our clinical development plans and are receiving regular validation for results reported to date, both through a presentation in April at the American Association for Cancer Research (AACR) annual meeting, and the acceptance of further data to be presented in a poster at the American Society of Clinical Oncology (ASCO) annual meeting, which is considered among the top annual oncology conferences. We are encouraged by the results we have reported, along with the early results we are seeing as we advance our trial, and believe they are indicative of the potential for Decoy20, and indeed our platform as a whole. We look forward to reporting more about our progress as it develops.”

On April 11, Indaptus announced it was proud to unveil its poster at the 2024 Annual Meeting of the American Association for Cancer Research (AACR) in San Diego on Wednesday, April 10th. The poster details mechanism of action data that demonstrates the Company’s Decoy platform successfully induces, matures or activates multiple immune cell types involved in anti-tumor responses. The latest findings significantly enhance the Company’s understanding of its “Decoy” platform technology, which uses killed, non-pathogenic bacteria engineered to activate the immune system to attack tumors. The study highlights the platform’s effectiveness in engaging key innate and adaptive immune cells, including, natural killer cells, natural killer T cells, dendritic cells, CD4+, and CD8+ T cells. In some settings, the platform also produced additive or synergistic activity in combination with IL-2, an approved cancer drug. Additionally, the data reveal that the Decoy platform may not only boost the immune system’s ability to recognize and kill tumor cells, but potentially also overcome a mechanism that suppresses the immune response. The results suggest that the Company’s Decoy bacteria can both directly and indirectly prime the immune system to more effectively fight cancer. Jeffrey Meckler, Indaptus’ Chief Executive Officer, added, “We are encouraged by the promising results observed in our preclinical studies and our ongoing Phase 1 clinical trial. The recognition and validation from prestigious organizations such as the AACR, coupled with the support and insights we are receiving from medical experts, partners and investors at the conference, inspire us to continue advancing our technology and demonstrating its significant therapeutic potential for the treatment of solid tumors.” The full poster can be accessed on the Indaptus Therapeutics website by clicking here.

Dr. Michael Newman, Indaptus’ Founder, Chief Scientific Officer, and lead author, commented, “The new data are consistent with our preclinical animal tumor model studies and provide evidence for our hypothesis that patented Decoy bacteria can activate a wide range of innate and adaptive human immune cells involved in fighting tumors. This aligns with what we’ve observed in our ongoing Phase 1 clinical trial of Decoy20 – broad immune activation, as evidenced by transiently increased levels of many key cytokines and chemokines following single dose administration. These findings bolster our confidence in Decoy20’s potential as a multifaceted immunotherapy.”

Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again as we move forward!

Investing & Inspiration

1. “A friend may well be reckoned the masterpiece of nature.” –  Ralph Waldo Emerson
2. “Nature uses as little as possible of anything.” – Johannes Kepler
3. “Every new beginning comes from some other beginning’s end.” – Seneca
4. “Nothing ever becomes real till it is experienced.” – John Keats
5. “Nobody who ever gave his best regretted it.” – George Halas
6. “Honest disagreement is often a good sign of progress.” – Mahatma Gandhi
7. “A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell
8. “They always say time changes things, but you actually have to change them yourself.” – Andy Warhol
9. “The secret of happiness is something to do.” – John Burroughs
10. “The world of reality has its limits; the world of imagination is boundless.”
11. “You begin with the possibilities of the material.” – Robert Rauschenberg
12. “The only Zen you can find on the tops of mountains is the Zen you bring up there.” – Robert M. Pirsig
13. “Leadership is the capacity to translate vision into reality.” – Warren Bennis
14. “A man should always consider how much he has more than he wants.” – Joseph Addison
15. “Happiness is good health and a bad memory.” –  Ingrid Bergman
16. “We pass through this world but once.” – Stephen Jay Gould
17. “Christmas waves a magic wand over this world, and behold, everything is softer and more beautiful.” – Norman Vincent Peale
18. “Nothing can have value without being an object of utility.” – Karl Marx
19. “Always turn a negative situation into a positive situation.” – Michael Jordan
20. “Courage is found in unlikely places.” – J. R. R. Tolkien
21. “One that would have the fruit must climb the tree.” – Thomas Fuller
22. “Someone is sitting in the shade today because someone planted a tree a long time ago.” – Warren Buffett
23. “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes
24. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” – George Bernard Shaw
25. “Everything in the world may be endured except continual prosperity.”  – Johann Wolfgang von Goethe
26. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
27. “Time is money.” – Benjamin Franklin
28. “Change before you have to.” – Jack Welch
29. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
30. “The Universe is under no obligation to make sense to you.” – Neil deGrasse Tyson
31. “Care and diligence bring luck.” – Thomas Fuller
32. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
33. “A man who is a master of patience is master of everything else.” – George Savile
34. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
35. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
36. “Act as if what you do makes a difference. It does.” – William James
37. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
38. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
39. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
40. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
41. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
42. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
43. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
44. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
45. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
46. “Action is the foundational key to all success.” – Pablo Picasso
47. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
48. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
49. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
50. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
51. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
52. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
53. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
54. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
55. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
56. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
57. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
58. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
59. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
60. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
61. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
62. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
63. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
64. “There is little that can withstand a man who can conquer himself.” – Louis XIV
65. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
66. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
67. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
68. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
69. “No man was ever wise by chance.” – Lucius Annaeus Seneca
70. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
71. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare

72. “It does not matter how slowly you go as long as you do not stop.” – Confucius

73. “I want to put a ding in the universe.” – Steve Jobs

74. “Research is creating new knowledge.” – Neil Armstrong

75. “The reward for work well done is the opportunity to do more.” – Jonas Salk
76. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
77. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey

78. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

79. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger

80. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

81. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

82. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain

83. “The best way out is always through.” – Robert Frost

84. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi

85. “Without labor nothing prospers.” – Sophocles

86. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein

87. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

88. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

89. “He who is brave is free.” – Lucius Annaeus Seneca

90. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

91. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

92. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

93. “He who knows that enough is enough will always have enough.” – Lao Tzu

94. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall

95. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

96. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
97. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
98. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
99. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
100. “You must do the things you think you cannot do.”- Eleanor Roosevelt
101. “Success is dependent on effort.” – Sophocles
102. “Nobody who ever gave his best regretted it.” – George Halas
103. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
104. “And when I breathed, my breath was lightning.” – Black Elk
105. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
106. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
107. “If you want a guarantee, buy a toaster.” – Clint Eastwood
108. “We are an impossibility in an impossible universe.” – Ray Bradbury
109. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
110. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
111. “Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
112. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
113. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
114. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
115. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
116. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
117. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
118. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
119. “There is more to life than increasing its speed.” – Mahatma Gandhi
120. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
121. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
122. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
123. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
124. “Life is too short for long-term grudges.” – Elon Musk
125. “There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
126. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
127. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
128. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
129. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
130. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
131. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
132. “Let there be work, bread, water and salt for all.” – Nelson Mandela
133. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
134. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
135. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
136. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
137. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
138. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
139. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
140. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
141. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
142. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
143. “Delete the negative; accentuate the positive!” – Donna Karan
144. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
145. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
146. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
147. “Everything has beauty, but not everyone sees it.” – Confucius
148. “A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
149. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
150. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
151. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
152. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
153. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
154. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
155. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
156. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
157. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
158. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
159. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
160. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
161. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
162. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
163. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
164. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
165. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
166. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
167. “There is little that can withstand a man who can conquer himself.” – Louis XIV
168. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
169. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
170. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
171. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
172. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
173. “Never do anything against conscience even if the state demands it.”– Albert Einstein
174. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
175. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
176. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
177. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
178. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
179. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
180. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
181. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
182. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
183. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
184. “The secret of getting ahead is getting started.” – Mark Twain
185. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe