Oil Prices Jump, Core CPI Drops As Stocks Straddle This Week – $ADT $ARM $INDP $RYZB $SHIP $SIL $TSLA Rise

Happy Saturday!

I hope that you had a wonderful week and are out and about enjoying the weekend.

As for the broad markets this week, the stock indices managed to waffle about a bit after last week’s drop and ahead of Fed’s next interest rate decision on Sept. 20, while the tech/growth/small stocks took another widely again. Clouding all views and potentially hitting the bottomline of a number of industries, including the airlines who widely warned throughout the week about the situation, OPEC+’s continued restrictive supply measures pushed oil prices a sizable 4.1% higher again to close at $91.10/bbl, while making the trip to the local gas station painful at best. The yield curve also moved uncomfortably higher as the 2-yr yield moved up 7bps to 5.04% and the 10-yr note hit 4.33% also moving up 7bps.

A number of macroeconomic reports hit the presses again this week as well sending a bit of a mixed message in the US and China actually surprised on Friday with improved retail numbers. On Tuesday, the August NFIB Small Business Optimism index report confirmed a drop to 91.3. On Wednesday, the August CPI data report overall showed a bit of improvement on a Y/Y basis. The Total CPI report came in with a .6% M/M rise in August meeting expectations and as gasoline prices was responsive for the majority of the rise. However, The Core CPI repot came in a bit better than expected at .3% M/M. The Total CPI rose 3.7% Y/Y .The macroeconomic schedule also produced the weekly MBA Mortgage Index report that showed a was down .8%. The Refinance Index report also showed a 5.4% decrease, but the the Purchase Index increased 1.3%. The August Treasury Budget report also came in with a $89.2B surplus. Lastly the Weekly crude oil inventories report confirmed a 3.954M barrel increase. On Thursday, the Weekly Initial Claims report came in at 220k, while the Weekly Continuing Claims report clocked in at 1.688M and remains relatively low. The August PPI came in higher at .7% and pushed higher by energy prices, while the August Core PPI came in at .2% and inline with expectations. The August Retail Sales report was confirmed at .6%. The July Business Inventories report came in at .0%. On Friday, the August Import Prices report came in higher at .5%, however August Import Prices sans-oil scam in at -.1%. The August Export Prices report came in at 1.3%. The September Empire State Manufacturing repot came in at 1.9. The August Industrial Production report came in at .4%, while the August Capacity Utilization report came in relatively flat at 79.7%. Lastly, the Preliminary September University of Michigan Consumer Sentiment repot came in lower at 67.7.

At the end of the week, the small caps on the Russell 2000 closed at 1,847.03 (-.2%) for the week & is now up 4.9% YTD. The Nasdaq fell .4% for the week & closed further below the 14k level at 13,708.30 and is now up 31% YTD. The Dow 30 closed at 34,618.20 (+.1%) this week and is now up 4.4% YTD. The S&P 500 closed at 4,450.32 (-.2%) for the week and is now up 15.9% YTD with 8 of the 11 sectors closing in the green with the information technology sector taking the heaviest hit off 2.2% and led by the 1.78% drop in Apple (AAPL, $175.01).

The balance of the Magnificent Seven (sans Apple) had a mixed week and performed as follows over the last 5-days: Alphabet (GOOG) closing at $137.20, -.11%, Amazon (AMZN) closing at $138.30, +.80%, Meta Platforms (META) closing at $300.31, +.81%, Microsoft (MSFT) closing at $330.22, -2.50%, NVIDIA (NVDA) closing at $439, -3.67% & Tesla (TSLA) closing at $274.39, +10.42% had a stellar week after analysts upgraded the stock.

The MicroCaps also moved lower this week as the iShares Micro-Cap ETF (IWC) closed at $104.23, -.58% this week & is now down 3.34% YTD. The CBOE Volatility Index (^VIX) fell .07% closing at $13.79 over the last 5 days.

The U.S. Dollar Index also rose again this week from 1.05.06 to 105.33 this week.  

Bank stocks rose in general as the SPDR S&P Regional Banking ETF (KRE) moved up .81% over the last 5-days to close at $43.71 and is now down 25.59% YTD & the SPDR S&P Bank ETF (KBE) also moved up by 1% over the last 5-days to close at $38.55.

Biotech sector valuations dropped back this week across the board.  The Nasdaq Biotechnology ETF (IBB) closed at $126.61, -.19% over the last 5-days and is now down 3.56% YTD, the NYSE ARCA Biotech Index (^BTK) closed at 5,183.08, -.33% over the last 5-days and is now down 1.86% YTD, & the SPDR S&P Biotech ETF (XBI) closed at $77.11, -1.96% over the last 5-days, & is now down 7.10% YTD. The 52-week range is is now $72.44-$92.60 and continues to get tighter.

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $43.06, -1.42% over the last 5-days and is up 37.84% YTD.   

The iShares U.S. Healthcare ETF (IYH) closed at $278.01, -.18% over the last 5-days and is now down 2.01% YTD.   

From the world of cryptocurrency, Bitcoin (BTC) moved to $26.674.98 up 3.26% over the course of the last 5-days at the time of the completion of this message.

Gold prices closed at $1,945.60, +$18.60/oz over the last 5-days. Silver prices closed at $23.305, +$.1705/oz over the last 5-days. The Gobal X Silver ETF (SIL) closed at $26.40, +5.68% over the last 5-days.

A couple of IPO’s entered showed up in the market favorably this week as follows: 

• On September, 13, Arm Holdings plc announced the pricing of its initial public offering of 95,500,000 American depositary shares (“ADSs”), each representing one of its ordinary shares, at a price to the public of $51.00 per ADS. The ADSs are expected to begin trading on the Nasdaq Global Select Market (“Nasdaq”) on September 14, 2023 under the symbol “ARM.” The selling shareholder, a wholly-owned subsidiary of SoftBank Group Corp., in the IPO has granted the underwriters an option to purchase up to an additional 7,000,000 ADSs to cover over-allotments, if any, for 30 days after the date of the final prospectus. The IPO is expected to close on September 18, 2023, subject to customary closing conditions. Raine Securities LLC is acting as financial advisor in connection with the IPO. Barclays, Goldman Sachs & Co. LLC, J.P. Morgan, and Mizuho are acting as joint book-running managers for the IPO. Barclays is acting as Billing and Delivery Agent, Goldman Sachs & Co. LLC is acting as IPO Allocation Coordinator, J.P. Morgan is acting as Stabilization Agent, and Mizuho is acting as Roadshow Launch Coordinator & Salesforce Presentation Host. Shares of ARM closed at $60.75 with a market valuation of $62.33 billion!

• On September 14, RayzeBio, Inc. (Nasdaq: RYZB, $24, +33%), a targeted radiopharmaceutical company developing an innovative pipeline against validated solid tumor targets,  announced the pricing of its upsized $311 million initial public offering of 17,277,600 shares of common stock at a price to the public of $18.00 per share. RayzeBio is offering 16,114,600 shares of common stock and the selling stockholder named in the prospectus is offering 1,163,000 shares of common stock. RayzeBio will not receive any proceeds from the sale of shares by the selling stockholder. The gross proceeds to RayzeBio from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by RayzeBio, are expected to be approximately $290.1 million. In addition, RayzeBio has granted the underwriters a 30-day option to purchase up to an additional 2,591,640 shares of common stock at the initial public offering price, less underwriting discounts and commissions. The shares are expected to begin trading on The Nasdaq Global Market on September 15, 2023 under the symbol “RYZB.” The offering is expected to close on September 19, 2023, subject to the satisfaction of customary closing conditions. J.P. Morgan, Jefferies, Evercore ISI and Truist Securities are acting as joint book-running managers for the offering.

VP Watchlist Updates

Lantern Pharma Inc. (NASDAQ: LTRN) closed at $4.06 and is up to $4.22, +3.94% in the aftermarket on Friday. Lantern is developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs. Lantern believes that the use of machine learning, genomics and computational methods can help accelerate the development and commercialization of small molecule-based therapies. These drugs can be targeted to patients whose genomic profile identifies them as having the highest probability of benefiting from the drug, thereby creating the potential to achieve better outcomes.Their proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. Learn more about Lantern at the VP Watchlist Page.  

On September 8, Lantern’s Chief Executive Officer, Panna Sharma, delivered a presentation titled “How Artificial Intelligence Is Crushing Drug Discovery Times & Costs In Cancer” at a Tribe Public CEO Presentation & Q&A Event. The Event video is now published at the Tribe Public YouTube Channel that you may view now by clicking here.

On August 31, Lantern announced that it will present positive data highlighting the anti-tumor potency of its drug candidate LP-284 for non-Hodgkin’s lymphoma (NHL) at the Society of Hematologic Oncology (SOHO) Eleventh Annual Meeting occurring on Sept. 6 – 9, 2023, at the George R. Brown Convention Center in Houston, Texas. LP-284 is a small molecule with a synthetically lethal mechanism of action that preferentially damages cancer cells.. Lantern is developing LP-284 for the treatment of relapsed or refractory NHL, including Mantle Cell Lymphoma and Double Hit Lymphomas. Lantern expects to initiate Phase 1 clinical trials for LP-284 during Q4 of 2023. Lantern’s LP-284 program has been accelerated and de-risked using AI insights and biological modeling powered by RADR®. Lantern has been able to advance LP-284 from initial RADR® insights regarding anti-cancer activity and potential mechanisms of action in hematological cancers, to selection of specific subtypes of lymphomas with superior response, to late-stage IND enabling studies, and initial design of first in human clinical trials in less than two years.

Details of the poster presentation are listed below and can be found on the SOHO website. A full version of the poster will be available on Lantern’s website on September 11, 2023.

Title: LP-284 – Targeting Homologous Recombination Deficiencies in B-Cell Non-Hodgkin’s Lymphomas with the Novel Anti-Tumor Small Molecule LP-284
Date and Time: September 6, 2023, 6:00pm CT
Poster Number: ABCL-180
Presenter: Jianli Zhou, Ph.D., Lantern Pharma

On August 28, Lantern announced a substantial increase in the power and capabilities of RADR® focused on improving the drug development process for immune checkpoint inhibitors (ICIs). These capabilities are expected to address the multiple challenges facing the increased usage of ICIs in cancer therapy. Since gaining regulatory approval in 2011, ICIs have improved the lives of tens of thousands of cancer patients as either monotherapies, and more recently, in combination regimens with other therapies. The success of ICIs has resulted in multiple competing ICI molecules, often from the same class, in overlapping cancer indications. Additionally, recent clinical trial failures reveal headwinds to the desired expansion of ICIs for a broader range of cancers and patient groups. Currently, there are over 5,200 ongoing clinical trials involving ICIs, many of these lacking adequate biomarker strategies or guidance from AI enabled approaches to optimize the selection of patient responder populations. In a recent study presented at the 2023 ASCO meeting, RADR’s® algorithms demonstrated an 88% accuracy rate in predicting which melanoma (skin cancer) patients exhibiting resistance to anti-PD1 therapy will respond to Elraglusib, a GSK-3ϐ inhibitor being developed by Actuate Therapeutics, which previously entered into a multi-year research and development collaboration with Lantern Pharma to leverage the RADR® platform. The continued growth of ICIs, especially the approval of new ICIs, will be predicated on: 1) efficiently identifying new biomarker or molecular signatures for optimal patient selection, stratification, and management, and 2) rapidly developing combination regimens that overcome treatment challenges facing current and emerging solid and hematological cancer indications. Lantern’s latest RADR® AI developments will focus on addressing these challenges by building automated and highly scalable computational analytics to generate clinically relevant tumor-specific and tumor-agnostic molecular signatures to guide the identification and development of drug combinations that can prolong ICI durability of response and improve patient survival. These developments will leverage RADR® to uncover molecular drivers of response and resistance influencing ICI treatment outcomes by coupling pathway and network-based analytics with the simultaneous screening of millions of targets from complex clinical and biological data sets. This capability will be powered by tens of billions of new data points from immunotherapy and checkpoint inhibitor studies that Lantern has begun to add to its RADR® platform.

Lantern plans to deploy its new RADR® ICI predictive module with biopharma partners and to identify potential combinatorial strategies for LP-184 and LP-284, the first of Lantern’s drug candidates developed internally with the assistance of the RADR® AI platform. The ICI market is projected to reach $67.8 billion in annual sales by 2025, according to GlobalData, with future growth dependent on approvals from precision-based approaches guiding the development and positioning of new combination therapies.

 

Panna Sharma is the President, CEO, and Board Member of Lantern Pharma Inc.

“We are expanding the functionality of our RADR® AI platform in ways that aim to solve the very meaningful and important challenges of future checkpoint inhibitor development. We initially began this effort by identifying meaningful combinations with checkpoint inhibitors that might be the most effective with our LP-184 and LP-284 drug candidates. Our latest RADR® advancements add a new level of speed, scalability, and precision in the identification of rational combination therapies that have the potential to overcome known shortcomings of ICIs. The current clinical trial landscape of ICIs is at a critical juncture, with dozens of new indications being pursued. Unfortunately, the majority of these trials are unlikely to succeed unless the right cancer subtypes are pinpointed and unless the right combinations with other molecules are pursued. ICIs have the potential to benefit from the ability to predict which patient groups and which cancer subtypes will respond to the drug or drug combination, which is a fundamental part of our AI platform, RADR®, as we recently demonstrated in our collaborative 2023 ASCO poster,”stated Panna Sharma, Lantern’s CEO and President.

On Aug 9. , Lantern hosted its second quarter 2023 operating and financial results webcast to discuss the operating and financial results for the second quarter ended June 30, 2023 and provide guidance on upcoming milestones. Panna Sharma, President and Chief Executive Officer of Lantern Pharma, will led the call & highlighted the following:

• Obtained FDA clearance of the IND application for LP-184 and activated initial clinical sites for the Phase 1 basket trial in relapsed/refractory advanced solid tumors and brain cancers – a patient population with unmet clinical needs,
• Completed IND-enabling studies for LP-284 and anticipate IND submission in August; first-in-human Phase 1 clinical trial targeted for Q4 in advanced non-Hodgkin’s lymphomas,
• Dosed initial patients in the Phase 2 Harmonic™ clinical trial for never smokers with NSCLC, who make up 15-20% of all lung cancer cases; continued expansion of additional clinical trial sites in the US and increased patient recruitment activity.
• Initiated RADR® collaboration with Bielefeld University to design and develop breakthrough antibody drug conjugates (ADCs) with greater precision and efficacy,
• Received US Patent & Trademark Office notice of allowance for composition of matter patent for LP-284, extending commercial protection into early 2039, &
• $48.0 million in cash, cash equivalents, and marketable securities as of June 30, 2023, providing a cash runway into 2025.

Indaptus Therapeutics, Inc. (Nasdaq: INDP, closed at $3.38, +10.46% over the course of the last 5-days after establishing a new 52-wk high of $3.399 on Friday and is up 133.10% YTD), a company with the ability to harness both the body’s innate and adaptive immune responses, believes they are uniquely positioned to revolutionize the treatment of cancer and certain infectious diseases.

Indaptus is a company with the ability to harness both the body’s innate and adaptive immune responses, believes that they are uniquely positioned to revolutionize the treatment of cancer and certain infectious diseases. Indaptus Therapeutics has evolved from more than a century of immunotherapy advances. The Company’s novel approach is based on the hypothesis that efficient activation of both innate and adaptive immune cells and pathways and associated anti-tumor and anti-viral immune responses will require a multi-targeted package of immune system-activating signals that can be administered safely intravenously (i.v.). Indaptus’ patented technology is composed of single strains of attenuated and killed, non-pathogenic, Gram-negative bacteria producing a multiple Toll-like receptor (TLR), Nucleotide oligomerization domain (Nod)-like receptor (NLR) and Stimulator of interferon genes (STING) agonist Decoy platform. The products are designed to have reduced i.v. toxicity, but largely uncompromised ability to prime or activate many of the cells and pathways of innate and adaptive immunity. Decoy products represent an antigen-agnostic technology that have produced single-agent activity against metastatic pancreatic and orthotopic colorectal carcinomas, single agent eradication of established antigen-expressing breast carcinoma, as well as combination-mediated eradication of established hepatocellular carcinomas and non-Hodgkin’s lymphomas in standard pre-clinical models, including syngeneic mouse tumors and human tumor xenografts. In pre-clinical studies tumor eradication was observed with Decoy products in combination with anti-PD-1 checkpoint therapy, low-dose chemotherapy, a non-steroidal anti-inflammatory drug, or an approved, targeted antibody. Combination-based tumor eradication in pre-clinical models produced innate and adaptive immunological memory, involved activation of both innate and adaptive immune cells, and was associated with induction of innate and adaptive immune pathways in tumors after only one i.v. dose of Decoy product, with associated “cold” to “hot” tumor inflammation signature transition. IND-enabling, nonclinical toxicology studies demonstrated safe i.v. administration without sustained induction of hallmark biomarkers of cytokine release syndromes, possibly due to passive targeting to liver, spleen, and tumor, followed by rapid elimination of the product. Indaptus’ Decoy products have also produced significant single agent activity against chronic hepatitis B virus (HBV) and chronic human immunodeficiency virus (HIV) infections in pre-clinical models.

On August 14, Indaptus announced financial results for the second quarter ended June 30, 2023 and provided a corporate update.

Jeffrey Meckler, CEO, Indaptus Therapuetics, Inc. (NASDAQ: INDP)

Jeffrey Meckler, Chief Executive Officer of Indaptus stated, “We have recently announced the completion of the first cohort of patients in our INDP-D101 trial evaluating Decoy20 for the treatment of solid tumors and receipt of authorization from the Safety Review Committee to advance into the second cohort. As previously announced, we are pleased to observe evidence of immune activation, along with short-lived adverse events consistent with Decoy20’s mechanism of action. We continue to analyze the data generated and anticipate that the data from the dose finding studies will guide the selection for the recommended Phase 2 dose for subsequent multi-dosing and combination studies, which are planned for 2024. An additional recent accomplishment is the appointment of industry veteran, Roger Waltzman, M.D., as our Chief Medical Officer. We anticipate benefiting from his expertise as we continue our Phase 1 trial and further develop the Decoy platform. In the meantime, we are prudently managing our cash position.”

Recent Corporate Highlights:

• The Company announced the completion of the first cohort of its INDP-D101 trial and receipt of authorization from its Safety Review Committee to proceed into the second cohort of the Phase 1 trial.
• A compound from the Company’s Decoy platform was presented in a poster titled, “A systemically administered killed bacteria-based multiple immune receptor agonist for pulsed anti-tumor immunotherapy,” at the American Association for Cancer Research Conference 2023. The poster highlighted that Decoy10 demonstrated 90% reduction of LPS-endotoxin activity and use of 100% killed, non-pathogenic bacteria.
• The Company’s Chief Scientific Officer, Michael Newman, Ph.D., was named Chair for two of the three days of the 4th STING & TLR-Targeting Therapies Summit held in Boston from May 9 to 11, where he was also a featured speaker.
• The Company received patent allowances for its Decoy immunotherapy platform in Brazil and India. The Indian patent allowance brought the number of countries in which the Company holds patent protection to 32.
• Roger Waltzman, M.D. was appointed the Chief Medical Officer of Indaptus, effective August 7, 2023.

Learn more about Indaptus Therapeutics (NASDAQ: INDP) at the VP Watchlist page by clicking here.

Shares of InMed Pharmaceuticals Inc. (INM), a leader in the research, development and manufacturing of rare cannabinoids, closed at $.83, down 2.35% over the last 5-days.

• On July 20, InMed provided a commercial and manufacturing update on its subsidiary BayMedica LLC (“BayMedica”), a leading supplier of bioidentical rare cannabinoids to the Health and Wellness (“H&W”) market. Highlighting the following: $2.3M revenues (unaudited) in Q4 2023, representing 123% increase quarter over quarter (“QoQ”), Optimized and scaled up manufacturing processes over the last 12 months to meet increasing demand, & Third consecutive quarter with significant revenue growth. Eric A. Adams, InMed’s President and CEO stated, “We are very encouraged to see another strong quarter with (unaudited) revenues in excess of $2.3M, representing our third consecutive quarter with significant revenue growth. As demand for minor cannabinoids continues to increase, we see a potential path for BayMedica to become a profitable standalone business subsidiary and contribute margin to the pharmaceutical R&D parent.”

• On June 22, InMed announced safety and efficacy results from its Phase 2 clinical trial, called 755-201-EB (the “Phase 2 Trial”), for the treatment of symptoms related to EB. The purpose of the Phase 2 Trial was to evaluate the safety of INM-755 CBN cream, which consists of the control cream plus the active pharmaceutical ingredient CBN, and obtain preliminary evidence of efficacy in treating symptoms and healing wounds over a 28-day period in patients with EB. All four subtypes of inherited EB, including EB Simplex, Dystrophic EB, Junctional EB, and Kindler Syndrome were accepted into the Phase 2 Trial. The Phase 2 Trial used a within-patient, double-blind design whereby matched index areas were randomized to INM-755 CBN cream or control cream. The Phase 2 Trial enrolled a total of 19 patients. Data from one patient were excluded from efficacy analyses due to a significant protocol deviation. Of the 18 remaining patients whose data were considered reliable for clinical review, 17 were treated for chronic non-wound itch and one patient was treated for wound-related itch. The remaining endpoints (pain, wound healing) could not be analyzed due to too few enrollees with such symptoms. Of the 18 participants assessed, chronic itch improved by a clinically meaningful amount in 12 patients (66.7%). InMed will pursue strategic partnership opportunities for INM-755 in epidermolysis bullosa (“EB”) and other itch-related skin conditions.
• On June 1, InMed announced that results from a neurodegenerative disease study was presented in a scientific poster at the Canadian Neuroscience Meeting in Montreal from May 28-31, 2023. The InMed sponsored research, entitled “Cannabinoids modulate cytotoxicity and neuritogenesis in Amyloid-beta-treated neuronal cells”, demonstrated the ability of a specific rare cannabinoid (“pCBx”) in InMed’s 900 Series library of potential candidates that reduces amyloid toxicity and tau protein expression while enhancing neuronal cell growth and neuritogenesis markers in vitro, all considered to be important targets in the potential treatment of neurodegenerative diseases such as Alzheimer’s. The research was conducted in the laboratory of Dr. Ujendra Kumar and Dr. Rishi Somvanshi of the faculty of Pharmaceutical Sciences at the University of British Columbia. Studies have shown that cannabinoids, via their endocannabinoid receptors (CB1R and CB2R) that naturally occur in the human body and brain, reduce amyloid-beta (“Aβ”) toxicity, decrease p-tau protein expression and provide neurite outgrowth, thus improving neuronal viability and function. The results presented demonstrate the anti-apoptotic effects of pCBx and its role in neuritogenesis in the cells of neuronal origin and support the role of pCBx as a potential therapeutic intervention in neurodegenerative diseases.

Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again as we move forward!

Investing & Inspiration

1. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
2. “A man who is a master of patience is master of everything else.” – George Savile
3. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
4. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
5. “Act as if what you do makes a difference. It does.” – William James
6. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
7. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
8. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
9. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
10. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
11. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
12. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
13. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
14. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
15. “Action is the foundational key to all success.” – Pablo Picasso
16. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
17. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
18. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
19. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
20. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
21. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
22. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
23. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
24. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
25. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
26. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
27. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
28. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
29. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
30. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
31. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
32. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
33. “There is little that can withstand a man who can conquer himself.” – Louis XIV
34. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
35. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
36. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
37. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
38. “No man was ever wise by chance.” – Lucius Annaeus Seneca
39. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
40. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare

41. “It does not matter how slowly you go as long as you do not stop.” – Confucius

42. “I want to put a ding in the universe.” – Steve Jobs

43. “Research is creating new knowledge.” – Neil Armstrong

44. “The reward for work well done is the opportunity to do more.” – Jonas Salk
45. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
46. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey

47. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

48. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger

49. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

50. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

51. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain

52. “The best way out is always through.” – Robert Frost

53. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi

54. “Without labor nothing prospers.” – Sophocles

55. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein

56. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

57. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

58. “He who is brave is free.” – Lucius Annaeus Seneca

59. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

60. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

61. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

62. “He who knows that enough is enough will always have enough.” – Lao Tzu

63. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall

64. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

65. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
66. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
67. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
68. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
69. “You must do the things you think you cannot do.”- Eleanor Roosevelt
70. “Success is dependent on effort.” – Sophocles
71. “Nobody who ever gave his best regretted it.” – George Halas
72. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
73. “And when I breathed, my breath was lightning.” – Black Elk
74. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
75. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
76. “If you want a guarantee, buy a toaster.” – Clint Eastwood
77. “We are an impossibility in an impossible universe.” – Ray Bradbury
78. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
79. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
80. “Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
81. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
82. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
83. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
84. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
85. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
86. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
87. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
88. “There is more to life than increasing its speed.” – Mahatma Gandhi
89. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
90. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
91. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
92. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
93. “Life is too short for long-term grudges.” – Elon Musk
94. “There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
95. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
96. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
97. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
98. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
99. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
100. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
101. “Let there be work, bread, water and salt for all.” – Nelson Mandela
102. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
103. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
104. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
105. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
106. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
107. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
108. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
109. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
110. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
111. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
112. “Delete the negative; accentuate the positive!” – Donna Karan
113. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
114. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
115. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
116. “Everything has beauty, but not everyone sees it.” – Confucius
117. “A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
118. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
119. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
120. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
121. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
122. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
123. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
124. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
125. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
126. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
127. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
128. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
129. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
130. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
131. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
132. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
133. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
134. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
135. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
136. “There is little that can withstand a man who can conquer himself.” – Louis XIV
137. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
138. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
139. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
140. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
141. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
142. “Never do anything against conscience even if the state demands it.”– Albert Einstein
143. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
144. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
145. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
146. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
147. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
148. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
149. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
150. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
151. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
152. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
153. “The secret of getting ahead is getting started.” – Mark Twain
154. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe