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Magnificent Seven & Large Caps Lead Weekly Gains As Small Caps Pull Back – $AAPL $BTC $DECK $INVO $LTRN $NVDA Rise!

By John F. Heerdink, Jr.
Quote of the Day: “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes



Happy Saturday!

I hope that you had a wonderful week and that you are enjoying a weekend with you and yours that is exceeding your expectations. 

After last week’s very significant jump in the markets, the broad markets this week saw the large caps continue to rise, albeit somewhat tempered and led my the highest weighted stocks, while the small & micro caps headed decidedly south. The earnings season rolled on and overall gave a decent showing, however the markets received yet another shot in the leg on Thursday from Fed Chair “Uncle Jerry Powell” when he shared during an IMF panel discussion the following, “The Federal Open Market Committee is committed to achieving a stance of monetary policy that is sufficiently restrictive to bring inflation down to 2 percent over time; we are not confident that we have achieved such a stance.” This statement led some to believe the Fed might actually raise rates again before the end of the year, which could put further and significant pressure on the US economy, jobs, and the housing markets to a degree that may cause significant harm.  Did you know that personal savings rates have dropped from 6% to 3.4% and consumers have increased their overall credit card debt to +$1 trillion as of the Q3 of 2023, which is the highest on record & that lending standards at the local bank remain very tight? Accordingly, the yield curve jumped significantly with the 2-yr yield moving up 19bps to 5.05% and the 10-yr moving from 4.51% to 4.63%. The U.S. Dollar Index also rose this week from 105.07 to 105.80. The CBOE Volatility Index (^VIX) pulled back again by 4.84% closing at $14.17 as it waffled around a bit, but basically stayed in pace after the +24% drop last week. On positive note and some led by increasing global growth concerns oil prices fell again by 4.1% (+9% over the last 2-wks) ending at $77.23/bbl and back in to the traditionally acceptable range ($60-$80).

A number of macroeconomic reports hit the presses again this week that included on Tuesday, the September Trade Balance report that came in at -$61.5B. The Consumer credit report revealed a $9B rise in September. On Wednesday, the Weekly MBA Mortgage Applications Index report came in at 2.5% & the September Wholesale Inventories report at .2%. On Thursday, the Weekly Initial Claims report came in higher at 217k and the Weekly Continuing Claims rose to 1.834M. On Friday, the Preliminary November University of Michigan Consumer Sentiment Report came in lower at 60.4. 

At the end of the week, the Dow 30 closed at 34,283,10 (+.7%) this week and is now up 3.4% YTD.

The S&P 500 closed at 4,415.24 (+1.3%) for the week and is now up 15.0% YTD. 6 of the 11 sectors moved higher this week as the top two performing sectors were the information technology sector rising 4.8% and the communication services sector rising 2.2%, while the energy sector dropped 3.8%, the utilities sector fell 2.6%& the real estate lost 2.1%. 

The Nasdaq closed at 13,798.10 (+2.4) and is now up 31.8% YTD.  

The Magnificent Seven closed as follows over the last 5-days: Alphabet (GOOG) closing at $134.06, +1.80%, Amazon (AMZN) closing at $143.56, +3.58%, Apple (AAPL, $186.40, +5.52%), Meta Platforms (META) closing at $328.77, +4.50%, Microsoft (MSFT) closing at $369.67, +4.78%, NVIDIA (NVDA) closing at $483.35, +7.40% & Tesla (TSLA) closing at $214.65, -2.41%.

After the 7.6% jump last week, the small caps on the Russell 2000 closed at1,760.70 (-3.1%) for the week & is now down 3.2% YTD. The MicroCaps also moved significantly lower this week as the iShares Micro-Cap ETF (IWC) closed at $94.74, -3.77% this week, but is now down 12.14% YTD after establishing yet another new 52-wk low at $90.70 recently.

Bank stocks on the SPDR S&P Regional Banking ETF (KRE) fell back 5.16% over the last 5-days to close at $41.37and is now down 29.57% YTD & the SPDR S&P Bank ETF (KBE) also moved down 3.85% over the last 5-days to close at $36.97.

The Biotech sector took yet another hit this week.  The Nasdaq Biotechnology ETF (IBB) closed at $115.53, -3.56% over the last 5-days and is now down 12.00% YTD, the NYSE ARCA Biotech Index (^BTK) closed at 4,639.09, -3.34% over the last 5-days and is now down 12.16% YTD, & the SPDR S&P Biotech ETF (XBI) closed at $66.95, -6.31 over the last 5-days, & is now down 19.34% YTD. The 52-week range is is now $63.80-$92.60 after establishing a new 52-wk low this week.

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $39.73, -1.76% over the last 5-days and is up 27.18% YTD.   

The iShares U.S. Healthcare ETF (IYH) closed at $263.14, -1.12% over the last 5-days and is now down 7.25% YTD.   

From the world of cryptocurrency, Bitcoin (BTC) moved to $37,147.98, +4.81% over the course of the last 5-days at the time of the completion of this message &  is up 118.08% over the last year.

Gold prices closed at $1,943 down from $1,997 over the last 5-days.  Silver prices closed at $22.31 up from $23.27 over the last 5-days. The Global X Silver ETF (SIL) closed at $22.305, -4% over the last 5-days.




VP Watchlist Updates


Deckers Brands (NYSE: DECK, $632.74, +5.9% over the last 5-days), a global leader in designing, marketing, and distributing innovative footwear, apparel, and accessories, announced financial results recently for the second fiscal quarter ended September 30, 2023. The Company also provided an update to its financial outlook for the full fiscal year ending March 31, 2024. “The strength of demand for our HOKA and UGG brands continued to drive exceptional performance, producing record revenue and earnings for Deckers in both the second quarter and first half of fiscal year 2024,” said Dave Powers, President and Chief Executive Officer. “Our team’s ability to deliver compelling products that create emotional connections with consumers through engaging marketing campaigns, differentiates our brands in a competitive marketplace. This, paired with our strategic approach to marketplace management, led by our DTC channel, remains paramount to the success of our brands and Company. We are focused on maintaining the integrity of our healthy brands to deliver the results detailed in our increased outlook, while remaining aligned with long-term objectives.”



Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP) closed at $2.33, -6.80% over the last 5-days, but closed $2.58, +10.73% in the aftermarket on Friday. INDP stocks is also up 60.69% YTD.

Indaptus is a company with the ability to harness both the body’s innate and adaptive immune responses, believes that they are uniquely positioned to revolutionize the treatment of cancer and certain infectious diseases. Indaptus Therapeutics has evolved from more than a century of immunotherapy advances. The Company’s novel approach is based on the hypothesis that efficient activation of both innate and adaptive immune cells and pathways and associated anti-tumor and anti-viral immune responses will require a multi-targeted package of immune system-activating signals that can be administered safely intravenously (i.v.). Indaptus’ patented technology is composed of single strains of attenuated and killed, non-pathogenic, Gram-negative bacteria producing a multiple Toll-like receptor (TLR), Nucleotide oligomerization domain (Nod)-like receptor (NLR) and Stimulator of interferon genes (STING) agonist Decoy platform. The products are designed to have reduced i.v. toxicity, but largely uncompromised ability to prime or activate many of the cells and pathways of innate and adaptive immunity. Decoy products represent an antigen-agnostic technology that have produced single-agent activity against metastatic pancreatic and orthotopic colorectal carcinomas, single agent eradication of established antigen-expressing breast carcinoma, as well as combination-mediated eradication of established hepatocellular carcinomas and non-Hodgkin’s lymphomas in standard pre-clinical models, including syngeneic mouse tumors and human tumor xenografts.

In pre-clinical studies tumor eradication was observed with Decoy products in combination with anti-PD-1 checkpoint therapy, low-dose chemotherapy, a non-steroidal anti-inflammatory drug, or an approved, targeted antibody. Combination-based tumor eradication in pre-clinical models produced innate and adaptive immunological memory, involved activation of both innate and adaptive immune cells, and was associated with induction of innate and adaptive immune pathways in tumors after only one i.v. dose of Decoy product, with associated “cold” to “hot” tumor inflammation signature transition. IND-enabling, nonclinical toxicology studies demonstrated safe i.v. administration without sustained induction of hallmark biomarkers of cytokine release syndromes, possibly due to passive targeting to liver, spleen, and tumor, followed by rapid elimination of the product. Indaptus’ Decoy products have also produced significant single agent activity against chronic hepatitis B virus (HBV) and chronic human immunodeficiency virus (HIV) infections in pre-clinical models.

On Nov. 6, Indaptus announced interim data from the first cohort of four patients in the Phase 1 INDP-D101 trial of its lead compound, Decoy20. A broad expression of cytokines and chemokines associated with innate and adaptive anti-tumor immune responses was observed, while adverse events were generally tolerable and resolved within 30 minutes to three days. Decoy20 is designed to “re-set” the immune system’s response to cancer. The poster was presented on November 4, 2023, at the Society for Immunotherapy of Cancer in San Diego.

“We are impressed that we saw short-term induction of more than 50 cytokines, chemokines and biomarkers and believe this is unprecedented with a single agent. These early data support our long-standing hypothesis that the Decoy platform may induce robust immune responses across multiple types of immune cells that we believe are important for the eradication of solid tumors,” commented Indaptus CEO Jeffrey Meckler. Learn more here. 

Also, on Nov. 6, Indaptus announced financial results for the third quarter ended September 30, 2023 and provided a corporate update.

We continue to be encouraged by early results from our first cohort of patients in the INDP-D101 trial evaluating Decoy20 for the treatment of solid tumors. As we recently reported and presented at the Society for Immunology in Cancer (SITC) conference, all four first cohort patients have maintained stable disease since receiving their single dose and presented evidence of immune activation, along with short-lived adverse events consistent with Decoy20’s mechanism of action, and we look forward to continuing to track them. In the meantime, we have already dosed our first patient in the second cohort, for which we have titrated the dose down in anticipation of a similar response. We continue to expect to have the second cohort completed by early 2024, which would provide guidance for the selection for the recommended Phase 2 dose for subsequent multi-dosing and combination studies, which are also planned for 2024,” said Jeffrey Meckler, Chief Executive Officer of Indaptus. “We are also fortunate to be receiving the benefit of our appointment of industry veteran, Roger Waltzman, M.D., as our Chief Medical Officer, who has already proven valuable even in this short period. We anticipate continuing to benefit from his expertise as we move forward with our Phase 1 trial and further develop the Decoy platform. In the meantime, we are prudently managing our cash position.”

On Sept, 29, Tribe Public hosted a Webinar Presentation and Q&A Event titled “Immunotherapy Reimagined” Indaptus Therapeutics’ (NASDAQ: INDP) CEO, Jeffrey Meckler delivered a presentation & also addressed a 5-10 minute Q&A session at the end of the presentation. You may view it now by clicking here. 


Learn more about Indaptus Therapeutics (NASDAQ: INDP) at the VP Watchlist page by clicking here.

Our sister organization, Tribe Public hosted a CEO Presentation and Q&A Webinar-based Event Tuesday, October 31 that was co-hosted by NAYA Biosciences (NAYA) Founder, Chairman, and CEO, Dr. Daniel Teper and was titled “Accelerating Biotech Value Creation”.   The event video is now published at the Tribe’s YouTube Channel and has now been viewed over 9k times. 

Dr. Teper has over 30 years of leadership experience as a biopharma entrepreneur, corporate executive, and management consultant. Previously, Dr. Teper was the Chairman & CEO of Cytovia Therapeutics, from 2019 to 2023, where he remains Chairman of the Board. Dr. Teper brings extensive experience. From 2011 to 2017, he was the CEO of Immune Pharmaceuticals, which he listed on NASDAQ. He previously served as New York-based Managing Partner (Head of North America) at Bionest Partners, now Accenture, where he advised companies on corporate strategy and business development. He was previously a Partner at ISO Healthcare Group, now Deloitte Monitor, in New York. Dr. Teper helped drive the accelerated growth of Softwatch, a pioneer digital health company, as senior vice president of sales and business development. He also served as global president of Havas Health, advising companies on global launches of major new drugs in multiple disease areas. Dr. Teper started his career at Novartis in Basel and then in the US, where he held management responsibilities in sales and marketing and as head of cardiovascular, new product development. Dr. Teper held general management positions in Europe at GlaxoSmithKline and Sanofi. He was the co-founder and CEO of Wintec Pharma, a European specialty pharmaceutical company focused on anti-infectives and dermatology, which he went on to sell. Dr. Teper co-founded Novagali, an ophthalmology specialty pharma later listed on EuroNext Paris and acquired by Japan’s Santen. He holds a Doctor of Pharmacy degree from Paris XI University and an MBA from INSEAD, where he was the J. Salmon scholar.



NAYA Biosciences is building a group of agile, disruptive, high-growth companies dedicated to increasing patient access to life-transforming treatments in oncology, fertility, and regenerative medicine.  NAYA’s capabilities in biology, cell and gene therapy, and artificial intelligence (AI) provide a synergistic platform for the accelerated clinical development and commercialization of these breakthrough treatments.  

  • NAYA Oncology aims to achieve clinical proof-of-concept for its two bispecific antibodies acquired from Cytovia Therapeutics, with the goal of advancing towards breakthrough outcomes for Hepatocellular Carcinoma and Multiple Myeloma patients. Clinical trials are expected to start in 2024.
  • NAYA Fertility aims to increase accessibility to advanced fertility care through a growing network of INVO-owned and affiliated clinics and the commercialization of INVO’s unique FDA-cleared INVOcell® device.
  • NAYA Regenerative Medicine is evaluating the acquisition of clinic-stage assets aiming to restore biological function in patients with damaged tissues and organs.


On Nov. 10, INVO and NAYA Biosciences Inc. (“NAYA”), a company dedicated to increasing patient access to breakthrough treatments in oncology and regenerative medicine, today jointly announced that following the closing of their pending merger, Dr. Peter Kash, Ed.D., MBA will join the combined company’s Board of Directors as Vice Chairman.

Dr. Kash has over 36 years of leadership experience in the biotech industry. He is currently the cofounder and Vice Chairman of TargImmune Therapeutics (Switzerland) and cofounder and Managing Director of Camelot BioCapital. He was formerly a cofounder and partner and Chairman of Two River Group and President of Riverbank Capital Securities, specializing in helping create and finance several biotech companies including Kite Pharma, Edgemont Pharmaceuticals, and Intercept Pharmaceuticals. He has cofounded more than a dozen biotech companies and coraised in excess of $2 billion in private/public financing, helping creating more than $20 billion in peak aggregate market value. Dr. Kash has worked on Wall Street for 30 years including at Shearson Lehman Hutton and Paramount Capital. At Paramount he cofounded and helped finance PolaRx Biopharmaceuticals; developing the first cancer drug from China, Trisenox approved by the FDA. The portfolio companies have received a total of 6 FDA approvals to date.

From 1990-1992 he was an Associate Professor of Marketing at Polytechnic University. During 1996-2000 he was an Adjunct Professor of Entrepreneurship at the Wharton Business School. During 2000-2002 he was a Visiting Professor of Entrepreneurship at the Graduate School of Business at Nihon University in Tokyo and in 2015 a Visiting Professor at Hebrew University. He has frequently lectured and served as a Keynote Speaker worldwide in many of the 70 countries he has visited.

His education includes a B.S. in Management Science from S.U.N.Y. Binghamton and an MBA in International Banking and Finance from the Lubin School of Business at Pace University. He holds a Doctorate in Education at The Azrieli Graduate School of Yeshiva University. Dr. Kash completed post graduate classes on Making Boards of Directors More Effective at Harvard Business School.

He has authored several books including a top international seller “Make Your Own Luck”, (Prentice Hall), now in 8 languages distributed in more than 30 countries.

On October 23, INVO, a healthcare services company focused on expanding access to advanced fertility treatment worldwide, and NAYA Biosciences Inc. (“NAYA”), a company dedicated to increasing patient access to breakthrough treatments in oncology and regenerative medicine, today jointly announced that they have entered into a definitive merger agreement (the “Merger”) for INVO to acquire NAYA Biosciences in an all-stock transaction. Under the terms of the agreement, NAYA Biosciences’ shareholders will receive 7.3333 shares of INVO for each share of NAYA Biosciences at closing, for a total of approximately 18,150,000 shares of INVO. Following the closing of the Merger, the combined company is expected to operate under the name “NAYA Biosciences”. Dr. Daniel Teper, currently Chairman & CEO of NAYA Biosciences, will be named Chairman & CEO of the combined company. Under the terms of the merger agreement, pending approval of the transaction by INVO’s, Cytovia’s, and NAYA’s stockholders and subject to key closing conditions, INVO will acquire 100% of the outstanding equity interests in NAYA by means of a reverse triangular merger of a wholly owned subsidiary of INVO with and into NAYA, with NAYA surviving as a wholly owned subsidiary of INVO (the “Merger”). On Friday, INVO shares closed at $1.31, +86.3442% and traded 71,711,588 shares of trading volume.


Shares of Atossa Therapeutics, Inc. (Nasdaq: ATOS), a clinical-stage biopharmaceutical company seeking to discover and develop innovative medicines in areas of significant unmet medical need in oncology, with a current focus on breast cancer and radiation-induced lung injury, closed at $.635, -9.29% over the last 5-days and is up 19.81% YTD.

On Aug. 14, Atossa announced financial results for the quarter ended June 30, 2023, and provides an update on recent company developments highlighted by the following: Achieved significant enrollment milestones in three ongoing Phase 2 clinical trials, Broadened patent protection for proprietary (Z)-endoxifen, Strengthened management team with appointment of Greg Weaver as Chief Financial Officer, & Ended second quarter 2023 with $99.4 million of cash and cash equivalents.

 

 

Shares of ADT Inc. (ADT), the most trusted brand in smart home and small business security, closed at $5.88, -4.08% over the last 5-days. ADT released its third quarter 2023 financial results recently and beat expectations. They highlighted the following progress: Significant balance sheet improvement driven by divestiture of commercial business, Record high CSB recurring monthly revenue balance driven by strong retention, Improved capital efficiency with record revenue payback of 2.0 years, & Continued innovation in core smart home security markets and rationalization of solar footprint.

On Oct. 2, GTCR, a leading private equity firm, announced that it has closed the acquisition of ADT’s commercial security, fire and life safety security businessfrom ADT Inc. (“ADT”, NYSE: ADT). Moving forward as a standalone organization, ADT Commercial will rebrand as Everon. GTCR will partner with former Protection1 executives Dan Bresingham and Tim Whall, along with other members of ADTC leadership, to acquire the Company, one of the leading national providers of electronic security and fire safety services to commercial enterprises and multi-site national accounts. Mr. Bresingham, former leader of ADT’s commercial security, fire and life safety business, will become Chief Executive Officer of Everon and Mr. Whall will serve as an active director on the Company’s Board.


Shares of Seanergy Maritime Holdings Corp. (SHIP), the only pure-play Capesize ship-owner publicly listed in the U.S. closed at $5.07, -.59% over the last 5 days. Seanergy (NASDAQ: SHIP) announced that it will release its financial results for the third quarter and nine months ended September 30, 2023, prior to the open of the market in New York on Tuesday, November 14, 2023.


Brad Hansen CEO of Holu Hou Energy (HHE), a company that uniquely brings state-of-the-art renewable energy and energy storage systems to the Single-Family Residential, Multi-Dwelling Unit Residential, and Commercial building markets, presented at our sister organization’s Tribe Public Webinar Presentation and Q&A Event titled “Discover How Multi-Dwelling Units Are Profitably Implementing Solar Energy Today.” The event video has now been published at the Tribe Public YouTube Channel and can be view now by clicking on this link

Note that HHE was recognized as the 2023 winner of the Innovative Tech Company of the Year at the 13th annual Pacific Edge Business Achievement Awards Gala in Honolulu, Hawai’i. With operations in California, Hawai’i, Wisconsin, and Shanghai, HHE engineers proprietary storage system and control platform solutions, including a breakthrough HHE “EnergyCluster” technology that is key to the development of the Multi-Dwelling Unit Residential housing market that uniquely allows for sharing amongst local units of excess energy created by solar energy production. This technology uniquely solves the key problems for installing solar energy for MDU tenant units: tenant load variability and tenant churn. Thus, HHE is essentially good for all parties. It is a vital partner for investors and asset owners who are seeking MDU renewable energy solutions that create a new and significant multi-year revenue stream. For tenants, the adoption is non-disruptive and, in practice, allows for energy control and localized resiliency. 

On Nov. 2, Holu Hou Energy LLC announced that it is has closed a $20M construction financing facility in support of the construction of Hawaii’s largest solar and energy storage project pipeline. The funding will enable procurement of the materials and EPC resources to construct MDU projects slated for completion in the next 4-quarters. HHE’s EnergyCluster Technology has  reportedly enabled the Largest Non-Utility Solar Project Pipeline in Hawaii – Approaching $1.0 Billion in Value.

 

Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again as we move forward!

Investing & Inspiration

  1. “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes
  2. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” – George Bernard Shaw
  3. “Everything in the world may be endured except continual prosperity.”  – Johann Wolfgang von Goethe
  4. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
  5. “Time is money.” – Benjamin Franklin
  6. “Change before you have to.” – Jack Welch
  7. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
  8. “The Universe is under no obligation to make sense to you.” – Neil deGrasse Tyson
  9. “Care and diligence bring luck.” – Thomas Fuller
  10. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
  11. “A man who is a master of patience is master of everything else.” – George Savile
  12. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
  13. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
  14. “Act as if what you do makes a difference. It does.” – William James
  15. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
  16. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
  17. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
  18. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
  19. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
  20. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
  21. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
  22. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
  23. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
  24. “Action is the foundational key to all success.” – Pablo Picasso
  25. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
  26. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
  27. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
  28. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
  29. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
  30. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
  31. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
  32. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
  33. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
  34. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
  35. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  36. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
  37. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
  38. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
  39. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
  40. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
  41. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  42. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  43. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
  44. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
  45. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  46. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
  47. “No man was ever wise by chance.” – Lucius Annaeus Seneca
  48. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  49. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  50. “It does not matter how slowly you go as long as you do not stop.” – Confucius

  51. “I want to put a ding in the universe.” – Steve Jobs

  52. “Research is creating new knowledge.” – Neil Armstrong

  53. “The reward for work well done is the opportunity to do more.” – Jonas Salk
  54. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
  55. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey
  56. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

  57. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger
  58. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

  59. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

  60. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain
  61. “The best way out is always through.” – Robert Frost

  62. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi
  63. “Without labor nothing prospers.” – Sophocles

  64. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein
  65. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

  66. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

  67. “He who is brave is free.” – Lucius Annaeus Seneca
  68. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

  69. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

  70. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

  71. “He who knows that enough is enough will always have enough.” – Lao Tzu

  72. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall
  73. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

  74. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
  75. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  76. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
  77. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
  78. “You must do the things you think you cannot do.”- Eleanor Roosevelt
  79. “Success is dependent on effort.” – Sophocles
  80. “Nobody who ever gave his best regretted it.” – George Halas
  81. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
  82. “And when I breathed, my breath was lightning.” – Black Elk
  83. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
  84. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
  85. “If you want a guarantee, buy a toaster.” – Clint Eastwood
  86. “We are an impossibility in an impossible universe.” – Ray Bradbury
  87. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
  88. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
  89. Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
  90. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
  91. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
  92. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
  93. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
  94. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
  95. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
  96. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
  97. “There is more to life than increasing its speed.” – Mahatma Gandhi
  98. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
  99. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
  100. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
  101. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
  102. “Life is too short for long-term grudges.” – Elon Musk
  103. There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
  104. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
  105. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
  106. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
  107. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
  108. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
  109. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
  110. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  111. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
  112. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  113. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
  114. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  115. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
  116. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
  117. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
  118. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
  119. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
  120. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
  121. “Delete the negative; accentuate the positive!” – Donna Karan
  122. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
  123. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
  124. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
  125. “Everything has beauty, but not everyone sees it.” – Confucius
  126. A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
  127. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
  128. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
  129. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  130. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  131. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
  132. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  133. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
  134. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  135. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
  136. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
  137. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
  138. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
  139. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
  140. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  141. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
  142. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
  143. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
  144. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  145. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  146. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
  147. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
  148. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
  149. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
  150. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
  151. “Never do anything against conscience even if the state demands it.”– Albert Einstein
  152. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  153. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
  154. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  155. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  156. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
  157. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
  158. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
  159. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
  160. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
  161. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
  162. “The secret of getting ahead is getting started.” – Mark Twain
  163. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe

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