Stock Market Today – Sept. 22, 2026 – Nasdaq Hits Record as AI Strength Offsets Macro and Energy Uncertainty -( $AMD $GME $GRML $INTC $LPL $META $NVDA $SER $VKTX $YSG )

U.S. equities finished mixed on Tuesday, September 22, 2026, with the Nasdaq Composite extending its advance to a fresh record while the Dow Jones Industrial Average declined. Investors continued to favor technology and AI-linked opportunities, even as regional manufacturing data softened and energy-policy developments kept inflation and geopolitical risks in focus.

U.S. Market Close

The Nasdaq Composite’s 0.45% gain contrasted with a 0.36% decline in the Dow Jones Industrial Average, showing that the market’s leadership remained concentrated in growth, AI and semiconductor-linked themes. The Russell 2000 added 0.58%, a constructive sign that smaller companies participated in the risk-on tone even as the broad S&P 500 finished essentially unchanged.

Market Commentary

Tuesday’s close delivered a split market: investors continued to reward secular-growth and AI-related opportunities, while the more traditional large-cap industrial and blue-chip complex lost ground. The Nasdaq closed at 27,244.28, while the S&P 500 finished at 7,764.64, just 0.06 point below its prior close. The low-volatility backdrop was also notable. The VIX fell 4.04% to 14.27, suggesting equity investors were not pricing in a sharp near-term increase in market stress, despite continued uncertainty surrounding crude oil, diesel-export policy and global security developments. Crude oil fell nearly 3% to $89.62 per barrel, providing a potentially constructive input for inflation expectations, consumer spending and transport-sensitive industries. At the same time, gold rose 0.42% to $4,402.20, indicating that investors still saw value in defensive and inflation-sensitive assets.

Macroeconomic Report

The Federal Reserve Bank of Richmond reported that Fifth District manufacturing activity weakened in September. Its composite manufacturing index fell to -2 from 4 in August, as the shipments index dropped to -5 from 11 and the new-orders index declined to -6 from 3. The employment component improved to 7 from -2. The report offers a mixed message for investors and policymakers:

• New orders and shipments moved back into contraction territory, signaling softer demand conditions in the region’s factory economy.
• Employment improved, suggesting that manufacturers were not yet responding to weaker demand with broad labor reductions.
• Pricing remained a concern, with the Richmond Fed indicating continued upward pressure in prices paid and prices received.
• The combination of slower industrial activity and persistent pricing pressure reinforces the challenge facing the Federal Reserve: growth may be cooling unevenly, but inflation risks have not disappeared.

The market implication is that investors will likely remain highly sensitive to upcoming labor, inflation and consumer-demand releases. Lower oil prices help at the margin, but a 10-year Treasury yield that has recently remained near elevated levels continues to restrain rate-sensitive sectors and valuations.

Stocks and Sectors

AI, chips and technology

Intel Corp. (NASDAQ: INTC) remained a closely watched semiconductor name after shares rallied roughly 25% over the prior five trading days. The move reflected renewed investor attention to central processing units as enterprises build AI-agent workflows, large-scale compute platforms and data-center capacity. The broader AI investment theme continues to include NVIDIA Corp. (NASDAQ: NVDA), Advanced Micro Devices Inc. (NASDAQ: AMD) and Meta Platforms Inc. (NASDAQ: META). Investors are increasingly evaluating the full AI infrastructure stack, including chips, networking, cloud capacity, data centers, power availability, software tools and AI-agent deployment rather than focusing only on graphics-processing-unit demand.

Consumer and corporate actions

GameStop Corp. (NYSE: GME) rose about 4% after CEO Ryan Cohen disclosed purchases of roughly 1.1 million shares worth approximately $26 million. The insider purchase gave the stock a company-specific catalyst and strengthened the market’s focus on management alignment. Insider buying can be viewed as a constructive signal, but it does not eliminate the operational, valuation and volatility risks associated with GameStop’s evolving strategy. Investors should distinguish insider sentiment from a sustained improvement in operating results.

Critical minerals and Greenland

Greenland Mines Ltd. (NASDAQ: GRML, $14.15, +50.21%) announced an application for a new exploration license covering approximately 262 square kilometers east of its existing Sarfartoq license. Approval would expand the company’s controlled area from about 192 square kilometers to about 454 square kilometers. The company’s announcement arrived as policy attention toward Greenland intensified. A reported U.S.-Denmark-Greenland security arrangement has highlighted the strategic importance of Arctic security, mineral resources and Western supply chains for rare earths and other critical materials. The added Greenland Mines area is not included in the company’s existing resource estimate or economic analysis. Its ultimate value will depend on permit approval, exploration results, project economics, financing conditions and long-term commodity demand.

Biotechnology and obesity care

Viking Therapeutics Inc. (NASDAQ: VKTX, $40.85, +35.67%) reported positive topline results from a maintenance study of its obesity-treatment candidate VK2735, a GLP-1/GIP agonist. The company reported 22% placebo-adjusted weight loss at week 33 in the weekly 17.5 mg cohort, with no plateau observed in the reported results. Viking also reported that patients transitioned to every-other-week dosing maintained up to 97% of induction-phase weight loss, while monthly dosing maintained up to 90%. If supported by further clinical development, less-frequent dosing could become a meaningful differentiator in the competitive obesity-drug market.

An Outlook

The central question for Wednesday is whether the Nasdaq-led advance can spread more broadly across the S&P 500 and Dow. The Russell 2000’s 0.58% gain offers a positive sign of participation beyond mega-cap technology, but the flat S&P 500 and lower Dow show that leadership remains selective. Many will be watching:

• Whether crude oil can remain below $90 per barrel and ease pressure on inflation expectations.
• New developments related to U.S. diesel-export policy and the Strait of Hormuz.
• The durability of AI and semiconductor demand, particularly for Intel Corp. (NASDAQ: INTC), NVIDIA Corp. (NASDAQ: NVDA) and Advanced Micro Devices Inc. (NASDAQ: AMD).
• Evidence of whether weak manufacturing readings are isolated or becoming a broader slowdown signal.
• Treasury yields, labor-market data and upcoming Federal Reserve communications.

VP Watchlist Updates

Amwell® (NYSE: AMWL)

Amwell® (NYSE: AMWL), a leading provider of a comprehensive SaaS-based software platform for technology-enabled healthcare, closed at $13.21.

AMWL announced (Sept 8) announced the Department of Veterans Affairs (VA) has declared its intent for the Company to deploy its virtual health platform within the VA enterprise and help power the modernization of the VA’s digital health infrastructure. The VA anticipates the Amwell platform will support a broad range of clinical services, enhance care coordination, and improve access for our Veterans across the VA enterprise. The Letter of Intent follows a comprehensive evaluation process by the VA, in which it determined that Amwell’s virtual health platform aligns with the Department’s strategic objectives to expand access to high-quality, secure, and reliable virtual care services for Veterans nationwide through the VA’s current electronic health record modernization efforts. Specifically, the capabilities Amwell demonstrated in scalable video consultations, interoperability, cybersecurity compliance, and support for integrated care delivery were significant factors in this determination.

Amwell® has received Frost & Sullivan’s 2026 United States Technology Innovation Leadership Recognition in the Technology-Enabled Care Platforms Industry. The recognition validates Amwell’s ability to address healthcare fragmentation through a unified platform that orchestrates consumer experiences, clinician workflows, care programs, and partner solutions.

The Company also reiterated recently its objective to achieve positive cash flow from operations in the fourth quarter of 2026.

Serina Theraeuptics (NYSE: SER)

Serina Theraeuptics (NYSE: SER, $2.31, +0.00%) is a clinical-stage biotechnology company developing a pipeline of wholly owned drug product candidates to treat neurological diseases and other indications. Serina’s POZ PlatformTM provides the potential to improve the integrated efficacy and safety profile of multiple modalities including small molecules, RNA-based therapeutics and antibody-based drug conjugates (ADCs). Serina is headquartered in Huntsville, Alabama on the campus of the HudsonAlpha Institute of Biotechnology.

On Thursday, September 24, 2026, at 8:30 a.m. PT / 11:30 a.m. ET, Serina CEO Steve Ledger will discuss the program’s progress during Tribe Public’s “A New Approach to Advanced Parkinson’s Disease: Serina Discusses SER-252’s Clinical Progress”webinar, followed by a live Q&A. The efficient 30-minute format may be especially useful for many tracking one of biotech’s most durable value-creation formulas: familiar pharmacology, differentiated delivery, and a clinical path with identifiable milestones. REGISTER AT: AdvancedParkinsonsDisease.TribePublic.com

SER announced (Sept. 9) that the independent Safety Monitoring Committee (SMC) has completed its blinded review of Cohort 1 of the ongoing Phase 1b registrational study of SER-252 in patients with advanced Parkinson’s disease and recommended that the study advance to Cohort 2. Cohort 1 evaluated the lowest dose level in the single-ascending-dose portion of the study. In addition to supporting continued dose escalation, blinded Cohort 1 observations showed a pharmacokinetic profile consistent with the sustained apomorphine exposure SER-252 is designed to provide and included sustained periods of improvement in motor function in individual patients on exploratory clinical measures.

Hudson Pacific Properties (NYSE: HPP)

Hudson Pacific Properties (NYSE: HPP, $12.08) is a real estate investment trust serving dynamic tech and media tenants in global epicenters for these synergistic, converging and secular growth industries. Hudson Pacific’s unique and high-barrier tech and media focus leverages a full-service, end-to-end value creation platform forged through deep strategic relationships and niche expertise across identifying, acquiring, transforming and developing properties into world-class amenitized, collaborative and sustainable office and studio space. HPP turned in a quarter ( Aug. 5) that suggests the office malaise is not over, but it may finally be meeting resistance. Revenue came in above Wall Street’s expectations, occupancy moved higher for a fourth straight quarter, and management raised full-year guidance, a combination that does not make for a triumphant victory lap, but it does make for a more credible turnaround narrative. Learn more.

Eupraxia Pharmaceuticals Inc. (EPRX)

Eupraxia Pharmaceuticals Inc. (EPRX, $8.58), a clinical-stage biotechnology company leveraging its proprietary Diffusphere™ technology designed to optimize local, controlled drug delivery for applications with significant unmet need, announced (Aug. 13) positive results from a new analysis of the RESOLVE study examining the effect of EP-104GI on symptom severity, including for the first time an analysis of the effect of EP-104GI on odynophagia (pain when swallowing). This is important because odynophagia scoring is a component of Dysphagia Symptom Questionnaire (DSQ), a commonly used patient reported outcome used in pivotal clinical trials in EoE patients.

Modular Medical, Inc. (NASDAQ: MODD)

Modular Medical, Inc. (NASDAQ: MODD, $2.22), a commercial-stage medical device company preparing for the commercial launch of its next-generation Pivot™ tubeless patch pump, announced (September 4) that it has secured a contract with a national U.S. pharmacy benefit manager (PBM) in the United States. Pursuant to the contract, the Company’s Pivot insulin delivery system is now available through the national PBM. The Company believes the engagement with this national PBM represents a significant step forward in broadening patient access to the Company’s Pivot tubeless patch pump and will further validate the Pivot pump as an accessible therapeutic option for people living with diabetes.

MODD announced (September 3) that the U.S. Food & Drug Administration (FDA) has cleared a set of software enhancements to its Pivot insulin delivery system, further expanding the system’s functionality and providing users with greater flexibility and customization options in bolus dosing, an enhanced user-interface (UI), and other software upgrades.

MODD CEO, Jeb Besser, co-hosted a Tribe Public’s CEO Presentation and Q&A Webinar Event titled “The Road To Revenue: Modular Medical’s Strategy For Launching Pivot,” that was held Friday, September 4, 2026 (8:30am PT / 11:30 am ET). You may watch the event video below now if you missed it below now.

MODD announced (Aug. 3) plans to initiate the first phase of commercialization of its Pivot tubeless patch pump across five strategically selected U.S. markets beginning in October 2026. The initial rollout will include Atlanta, Cincinnati/Lexington, Dallas, Houston, and Philadelphia, representing a foundational step in the Company’s capital efficient commercialization strategy with its mission to expand access to simplified insulin delivery solutions for all people living with diabetes.

MODD recently (July 22) announced the formation of its Pivot Innovation Council, a cross-functional group of leading clinicians and healthcare experts established to help guide the company’s clinical and commercial strategy. Diabetes care expert Robert Gabbay, MD, PhD, FACP was appointed as chair of the Pivot Innovation Council. The council will provide insights on target patient populations, support optimization of clinical workflows, inform evidence-generation initiatives, and help refine the Pivot product roadmap and go-to-market approach, as the Company continues to scale its differentiated offering.

Modular released findings (July 15) from an independent market research study demonstrating positive receptivity to its FDA-cleared Pivot™ tubeless patch pump due to its differentiated design, streamlined user experience, and potential for reimbursement through the pharmacy channel.

Similarweb Ltd. (NYSE: SMWB)

Similarweb explores the many ways AI, apps, and other transformational forces are changing online shopping in its State of Ecommerce 2026 report, published on Sept 10. They reported that despite increasing more than 200% over the past year, direct referrals from dedicated AI platforms don’t produce a large volume of traffic to ecommerce marketplaces and online stores. In other words, compared with search, AI conversations don’t result in as much immediate click-through traffic. However, AI buying recommendations exert an outsize influence on purchases – in some cases, giving the recommended brand a 2-to-1 advantage over its competitors. Consumers are also making ChatGPT, Gemini, and other conversational AI tools a routine part of the buying process. However, that doesn’t mean they are abandoning search, 89% of the time, consumers who use AI in their shopping research also use search. “Consumers are not switching tools, they are stacking them,” said Daniel Reid, Principal Insight Analyst, Consumer Goods & Retail at Similarweb and the lead author of the report. “People are using AI to explore and narrow options while still turning to Search to move toward a decision. The most complex journeys, the ones that use both, convert the best. Retailers and brands who figure out how to master these new paths to product discovery stand to benefit.”

Similarweb Ltd. (NYSE: SMWB) and NIQ (NYSE: NIQ) have recently announced their planned Agentic Commerce Measurement solution aims to connect AI-based product discovery with consumer intent, traffic, conversion and verified sales outcomes. The first version is expected in the fourth quarter of 2026, initially across selected categories and markets. For many, the strategic appeal is simple: as AI becomes an increasingly consequential front door to commerce, the value may accrue not only to the companies building AI assistants, but also to the data-and-measurement providers that tell enterprises whether all that artificial intelligence is generating actual revenue, or merely very articulate window-shopping.

SMWB also recently delivered the sort of second-quarter report investors tend to enjoy: revenue and profitability exceeded guidance, full-year expectations moved higher, and AI demand translated into contracts rather than merely conference-call poetry. SMWB closed at $8.50, +.24%. Learn More.

LG Display Co., Ltd. (LPL)

LG Display Co., Ltd. (NYSE: LPL, $3.04, +0.00%) has spent the last few years doing something many hardware companies talk about but few execute well: turning a technology pivot into a full‑blown business transformation that everyday investors can actually follow. Instead of chasing commoditized LCD TV panels in a race to the bottom, LPL is leaning into Gaming OLED, CES‑worthy innovation, and premium automotive displays – and the press trail tells a surprisingly investor‑friendly story.

Yatsen Group (NYSE: YSG)

Yatsen Group (NYSE: YSG, $2.73, +4.60%), a leading China-based beauty group, delivered the sort of quarter that can make a turnaround investor sit up straighter: reported revenue grew, its strategically important skincare operation accelerated sharply, and the company is increasingly built around clinical and premium brands rather than a pure color-cosmetics play. The results are not yet a victory lap, losses widened and third-quarter guidance is cautious, but YSG’s transformation is beginning to look less like a cosmetic touch-up and more like a genuine renovation.

YSG announced (July 8) a landmark collaboration to bring its flagship brand, Perfect Diary, to Sephora in China. This partnership integrates Yatsen’s rigorous scientific infrastructure with the world’s leading prestige beauty retailer, marking a significant milestone in Yatsen’s continuing evolution into a global beauty technology powerhouse.

Doximity, Inc. (NYSE:DOCS)

Doximity (NYSE: DOCS, $26.51) is the leading digital platform for U.S. medical professionals. The company’s network members include more than 85% of U.S. physicians across all specialties and practice areas. Doximity provides its verified clinical membership with digital tools built for medicine, enabling them to collaborate with colleagues, stay current on medical news and research, manage their careers and on-call schedules, streamline documentation and administrative paperwork, and conduct virtual patient visits.

Doximity, Inc. (NYSE: DOCS) announced (Aug. 6) results of its fiscal 2027 first quarter ended June 30, 2026. Jeff Tangney, co-founder and CEO of Doximity, “We’re proud that our clinical AI assistant, Doximity Ask, was the top-performing U.S.-based model in the NOHARM benchmark while we delivered another quarter of record engagement. In Q1 we had accelerated revenue growth along with workflow active prescriber growth of more than 30% year-over-year and AI Search query growth of over 25% quarter-over-quarter.”

Fiscal 2027 First Quarter Financial Highlights

All comparisons, unless otherwise noted, are to the three months ended June 30, 2025.

• Revenue: Revenue of $156.6 million, versus $145.9 million, an increase of 7% year-over-year.
• Net income and non-GAAP net income: Net income of $24.3 million, versus $53.3 million, representing a margin of 15.5%, versus 36.5%. Non-GAAP net income of $55.0 million, versus $71.9 million, representing a margin of 35.1%, versus 49.2%.
• Adjusted EBITDA: Adjusted EBITDA of $74.8 million, versus $79.8 million, a decrease of 6% year-over-year, representing adjusted EBITDA margins of 47.7%, versus 54.7%.
• Diluted net income per share and non-GAAP diluted net income per share: Diluted net income per share was $0.13, versus $0.27, while non-GAAP diluted net income per share was $0.29, versus $0.36.
• Operating cash flow and free cash flow: Operating cash flow of $42.0 million, versus $62.1 million, a decrease of 32% year-over-year, and free cash flow of $39.6 million, versus $60.1 million, a decrease of 34% year-over-year.

Financial Outlook

Doximity is providing guidance for its fiscal second quarter ending September 30, 2026 as follows:

• Revenue between $170 million and $171 million.
• Adjusted EBITDA between $80.5 million and $81.5 million.

Doximity is updating guidance for its fiscal year ending March 31, 2027 as follows:

• Revenue between $671 million and $681 million.
• Adjusted EBITDA between $309 million and $329 million.

Sable Offshore Corp. (SOC)

Sable Offshore Corp. (NYSE: SOC, $4.31) has moved from the awkward “pre-revenue restoration project” phase into something much more recognizable to Wall Street: a company selling meaningful volumes of oil, generating operating cash flow, and building momentum into a potentially larger 2027 earnings base. The second-quarter report on Monday was not a polished victory lap—midstream bottlenecks and one-time costs made sure of that—but it offered something potentially more valuable: proof that the Santa Ynez Unit restart is translating into barrels, revenue, and operational traction. Learn more.

T1 Energy Inc. (NYSE: TE)

T1 Energy Inc. (NYSE: TE, $4.36) offers a different type of growth story: one rooted in domestic production, trade-policy tailwinds and execution on solar manufacturing capacity. T1 announced (Aug. 27) that local officials in Mo i Rana, Norway, have rezoned a portion of the company’s Giga Arctic campus, allowing for the development of a data center. T1 is pursuing multiple pathways to monetize this brownfield facility as part of a value optimization initiative.

T1 recently reported second-quarter net sales of $250.1 million, produced 935 megawatts of solar modules at its G1_Dallas facility and generated adjusted EBITDA of $10.7 million. The company also monetized $39.1 million of 2025 Section 45X tax credits and ended the quarter with $156.4 million in cash, cash equivalents and restricted cash, including $79.1 million unrestricted. The headline loss should not be ignored: T1 reported a $36.9 million net loss from continuing operations, while its adjusted EBITDA benefited from $24.4 million in tariff refunds recognized in cost of sales. Yet the more interesting investor question is whether the company is creating a viable U.S. solar-manufacturing platform at a time when supply-chain security and domestic energy capacity carry unusually high strategic value. The company expects its first solar cells from a planned 2.1-gigawatt manufacturing facility in the first quarter of 2027. With 3 gigawatts of firm contracts, a 641-megawatt offtake agreement with Clearway and 2026 output expected toward the upper end of its 3.1-to-4.2-gigawatt range, T1’s story is increasingly about turning production capacity into contracted revenue. For investors, TE is less a conventional earnings multiple story than an execution-and-optionality story. If domestic solar demand remains durable and manufacturing milestones stay on schedule, the market may ultimately value the company less like a troubled commodity producer and more like a strategically positioned industrial platform.

Nvidia (NVDA, $228.87, +.66%)

NVDA announced plans (Sept. 3) to acquire open-AI platform Hugging Face for approximately $13 billion, with closing expected in 2027. The move reinforces NVIDIA’s effort to deepen its position across AI infrastructure, development tools, and the open-source AI ecosystem. Learn More.

Nvidia once again delivered (Wed., August 26) results that made Wall Street’s estimates look rather conservative. After the bell on Wednesday, NVIDIA, for its fiscal second quarter, the AI-chip leader reported adjusted earnings of $2.22 per share, ahead of the $2.10 consensus forecast, while revenue reached $96.22 billion, comfortably above expectations of $92.17 billion. The performance underscores Nvidia’s central role in the global AI buildout, where demand for its computing hardware continues to turn ambitious data-center plans into exceptionally large purchase orders. In short: the company remains one of the market’s preferred ways to bet on artificial intelligence, and, judging by the numbers, the machines are still very much hungry.

The Sources

1. CNBC Stock Market Today: Live Updates
2. CNBC Trump Administration Examining Whether a Diesel Export Ban Is Feasible
3. CNBC U.S. Strikes Greenland Security Deal and Plans Cold War-Era Base Reopening
4. Yahoo Finance GameStop Stock Jumps After CEO Ryan Cohen Buys $26 Million in Shares
5. Yahoo Finance Greenland Mines Applies to More Than Double Its Sarfartoq Rare Earth District Footprint
6. Yahoo Finance Intel Stock Up 25% in Five Days on CPU Demand as AI Agents Gain Traction
7. Yahoo Finance Viking Therapeutics Announces Positive Topline Results for VK2735 Maintenance Study
8. Federal Reserve Bank of Richmond Fifth District Survey of Manufacturing Activity, September 2026
9. Market Data Screenshot U.S. Indexes, VIX, Gold, Bitcoin and Crude Oil Closing Performance, September 22, 2026