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Interest Rates & Tesla Fly While Indices Drop Widely This Week – $ADT $EPRX $MODD $NVDA $OKLO $RKLB $TSLA Rise!

By John F. Heerdink, Jr.

As the curtain fell on another thrilling week in the stock market soap opera, investors found themselves on a rollercoaster ride that would make even the most seasoned theme park enthusiast queasy. After six weeks of gains that had the S&P 500 and Dow Jones Industrial Average strutting their stuff at record highs, the market decided it was time for a breather – or perhaps a dramatic pause for effect. The S&P 500, like a diva past her prime, stumbled 1.0% lower this week, while the Dow Jones Industrial Average took a nosedive worthy of a Hollywood stuntman, plummeting 2.7%. It seems the profit-taking activity was fueled by rising market rates, proving once again that in the world of finance, what goes up must come down – and then go back up again, because why not?

Meanwhile, the Treasury market decided to join the party, with yields rising faster than a helium-filled balloon at a children’s birthday party. The 10-year yield settled 16 basis points higher at 4.23%, while the 2-year yield wasn’t far behind, climbing 15 basis points to 4.10%. The 2s10s spread expanded by a whopping one basis point to 13 bps, a move so exciting it could barely keep investors awake. But fear not, dear readers, for in this tale of financial woe, there was a glimmer of hope! The Nasdaq Composite, like a plucky underdog in a feel-good sports movie, managed to eke out a 0.2% gain for the week. It seems the tech-heavy index was carried to victory on the broad shoulders of mega-caps and semiconductor shares, proving that in the stock market, size does matter. 

The Russell 2000, representing the small-cap stocks dropped a whopping 3.2% weekly gain as rates rose substantially and as it turned in to a “risk off” environment.   The micro mini stocks represented by the iShares Micro-Cap ETF (IWC) closed at $124.33, -3.14% over the last 5-days. The SPDR S&P 500 Biotech ETF (XBI) also dropped by 2.68% over the last 5-days,

Tech Titans This Week

* Apple (AAPL) closed at $231.41, down 1.53% for the week.  

* NVIDIA (NVDA) added another 2.57% over the five-day period to end at $141.54 and now enjoys a $3.47T Mkt cap, buoyed by the company’s ongoing dominance in AI chips and data center solutions continued to drive investor enthusiasm.

*Tesla (TSLA): Zoomed up by an electrifying 21.97% over the last 5-days after unveiling some shiny Q3 earnings and an optimistic vehicle growth estimate for 2025. Elon Musk must be doing his happy dance somewhere in space.

* Dell Technologies (DELL) closed at $122.54, -3.10% over the last 5-days.

* Advanced Micro Devices (AMD) closed at $156.23, +.17% over the last 5-days.

* Taiwan Semiconductor (TSMC) beat quarterly expectations recent and moved up +1.37% over the last 5-days. 

VP Watchlist Updates

Now let’s check out how these nuggets progressed below!


Oklo Inc. (NYSE: OKLO, $19.09, +4.72% over the last 5-days and up +131.96% over the last month), an advanced fission power technology and nuclear fuel recycling company, today announced that the U.S. Department of Energy (DOE) has approved the Conceptual Safety Design Report (CSDR) for the Aurora Fuel Fabrication Facility at Idaho National Laboratory (INL). This approval is a key milestone as Oklo advances toward its goal of utilizing recovered nuclear material to fuel its first commercial Aurora powerhouse. The Aurora Fuel Fabrication Facility is expected to fabricate fuel for Oklo’s Aurora power plant to be sited at INL. The facility will use high assay low enriched uranium that has been recovered from used Experimental Breeder Reactor-II fuel. “We are proud of our collaboration with INL and DOE as we move closer to turning on our first commercial plant that uses this recovered nuclear fuel in just a few years,” said Jacob DeWitte, co-founder and CEO of Oklo. Oklo is uniquely positioned with a secured fuel supply, site use permit, significant regulatory traction, and supply chain development to support the first deployment of its Aurora powerhouse.


 

The global diabetes care market, valued at $18.9 billion in 2023, is projected to reach $35.8 billion by 2028, with the insulin pump segment expected to grow from $5.26 billion to $21.65 billion by 2032. As reported by Fortune Business Insights, this rapid growth is driven by increasing diabetes prevalence and technological advancements in insulin delivery devices.

Modular Medical, Inc. (NASDAQ: MODD, $2.22, +.45% over the last 5-days and is up 117.65% over the last year), an insulin delivery system technology company preparing to launch a market expansion product with a more accessible, easier to prescribe, and easier to pay for and live with technology. Using its patented technologies, the company seeks to eliminate the tradeoff between complexity and efficacy, thereby making top quality insulin delivery both affordable and simple to learn. Their mission is to improve access to the highest standard of glycemic control for people with diabetes taking it beyond “superusers” and providing “diabetes care for the rest of us.” Modular Medical was founded by Paul DiPerna, a seasoned medical device professional and microfluidics engineer. Prior to founding Modular Medical, Mr. DiPerna was the founder (in 2005) of Tandem Diabetes and invented and designed its t:slim insulin pump. More information is available at https://modular-medical.com.

In October, Modular’s CEO was interviewed by Carole Sullivan on the Today In Nashville program affiliated with Channel 4 WSMV. The segment is called “New Tools for Treating Diabetes by Modular Medical.” You may watch the video now at this link.

On September 18, Modular Medical announced the issuance of U.S. Divisional Patent Application No. 17/968,599. “The issuance of this patent and the associated claims represent a major step in our efforts to protect the intellectual property in the MODD1 pump platform,” stated Jeb Besser, CEO of Modular Medical. “Some of the key features of our novel, low-cost and accurate insulin delivery technology are now protected by this important issued U.S. patent, which we believe represents a significant new barrier to entry. Our eight families of patents around our pump are an important part of our strategic value and market positioning, and we look forward to announcing further issuances on our portfolio in the future.”

On September 11, Modular Medical’s CEO Jeb Besser presented at Tribe Public’s Webinar Presentation and Q&A Event titled “Diabetes, Obesity, GLP-1, & The MODD-1 Opportunity.” The event video has now been viewed over 47,000 times and can now be viewed below:

On Wednesday, September 4, Modular announced it has received U. S. Food and Drug Administration (“FDA”) clearance to market and sell its MODD1 pump in the United States. With its commercial manufacturing infrastructure substantially established, the Company anticipates the MODD1 should be available for sale in early 2025.

 

James (Jeb) Besser, CEO of Modular Medical (NASDAQ: MODD)

“For too long, the benefits of superior glycemic control achieved by insulin pumps have, due to cost and complexity, been restricted to only the most sophisticated, motivated and well-insured users. The goal of Modular Medical has always been to change this by making diabetes technology accessible and affordable to underserved communities. We seek to make the experience of going ‘on a pump’ simpler and less intimidating and to widen the base beyond the current pump users,” said Jeb Besser, CEO of Modular Medical.


Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP) closed at $1.3501, -10.59% over the last 5-days.  Indaptus is a company with the ability to harness both the body’s innate and adaptive immune responses, believes that they are uniquely positioned to revolutionize the treatment of cancer and certain infectious diseases. Indaptus Therapeutics has evolved from more than a century of immunotherapy advances. The Company’s novel approach is based on the hypothesis that efficient activation of both innate and adaptive immune cells and pathways and associated anti-tumor and anti-viral immune responses will require a multi-targeted package of immune system-activating signals that can be administered safely intravenously (i.v.). Indaptus’ patented technology is composed of single strains of attenuated and killed, non-pathogenic, Gram-negative bacteria producing a multiple Toll-like receptor (TLR), Nucleotide oligomerization domain (Nod)-like receptor (NLR) and Stimulator of interferon genes (STING) agonist Decoy platform. The products are designed to have reduced i.v. toxicity, but largely uncompromised ability to prime or activate many of the cells and pathways of innate and adaptive immunity. Decoy products represent an antigen-agnostic technology that have produced single-agent activity against metastatic pancreatic and orthotopic colorectal carcinomas, single agent eradication of established antigen-expressing breast carcinoma, as well as combination-mediated eradication of established hepatocellular carcinomas and non-Hodgkin’s lymphomas in standard pre-clinical models, including syngeneic mouse tumors and human tumor xenografts.

On October 22, Indaptus announced a clinical supply agreement with BeiGene (BGNE). Building on Indaptus’ preclinical observation that Decoy20, when combined with a PD-1 inhibitor, induced complete cancer regressions and immunological memory in animal models, Indaptus plans to advance human clinical evaluation of the combination of BeiGene’s anti-PD-1 antibody, tislelizumab, with Indaptus’ Decoy20, a novel treatment designed to induce a broad immune response to fight cancer. Indaptus’ Decoy20 is being studied for its potential to treat a variety of cancers, including liver, colon, and pancreatic. PD-1 inhibitors are considered key agents in modern immunotherapy and have produced impressive response rates in some patients. In preclinical studies, Decoy20, when used in combination with a PD-1 inhibitor and an oral non-steroidal anti-inflammatory agent, demonstrated tumor eradication rates of 80-100%. Indaptus hopes to find a treatment combination that similarly improves outcomes in humans.

“PD-1 inhibitors have proven to be meaningful in treating multiple types of cancer. We are optimistic that we can improve outcomes by broadly and safely stimulating the immune system in a way that could enhance overall effectiveness of currently approved cancer treatments,” said Jeffrey Meckler, CEO of Indaptus Therapeutics. “This agreement with BeiGene marks a significant step forward in the search for curative cancer treatments for some of the most challenging cancers. Additionally, we view this as a significant milestone for Indaptus.”

As part of the agreement, BeiGene will provide Indaptus with access to its PD-1 inhibitor as well as technical expertise in order to accelerate the first clinical trial combining the two investigational drugs. Decoy20 utilizes Indaptus’ unique “Pulse-Prime” approach, which induces a strong and broad boost to the immune system but clears rapidly with only transient and tolerable side effects.

“Decoy20’s ability to synergize with a variety of approved therapeutic modalities, including checkpoint therapy, makes it a promising partner for several novel combination approaches,” said Dr. Michael Newman, Founder and Chief Scientific Officer at Indaptus. “This trial could reshape the checkpoint therapy landscape, as it will be the first time a short but broadly acting agent such as Decoy20, utilizing our innovative Pulse-Prime approach, will be tested in combination with a PD-1 inhibitor.”

On October 15, Indaptus Therapeutics, Inc. (Nasdaq: INDP) provided an update regarding key clinical advancements in its Phase 1 trial of lead drug candidate Decoy20. The Safety Review Committee examined weekly administration data at the lower Decoy20 dose and cleared unrestricted enrollment of patients at this dose. The safety profile observed to date remains aligned with Decoy20’s expected mechanism of action. The most clinically relevant treatment-related adverse events include Grade 2 Infusion Related Reaction and Grade 2 Hypotension, both of transient duration.  Jeffrey Meckler, Chief Executive Officer, added, “We continue to gather robust data on Decoy20, which remains consistent with our expectations from preclinical studies. We believe the continuation of this trial, and the eventual initiation of combination therapy studies presents an important opportunity to have a potentially significant impact on cancer immunotherapy. We look forward to sharing these results in the coming months.”


Lantern (LTRN) closed at $3.34, -2.91% over the last 5-days and is up +18.02% over the last year.  Lantern is an Artificial Intelligence (AI) firm that is transforming the cost, pace, and timeline of oncology drug discovery and development and specifically is developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs.

On October 22. Lantern announced that they will be participating in and hosting two webinars that are open to the public during October. Lantern expects to discuss in detail how big data and AI are being leveraged to advance the development of multiple indications for drug-candidates LP-184 and LP-284 during the “Leveraging Artificial Intelligence to Develop Therapies for Brain and Childhood Cancers” at 8:30am pacific on Monday, October 28. Register here. Lantern will also discuss how their algorithm for blood-brain-barrier (BBB) penetrability played a critical role in supporting the development of LP-184 across multiple CNS cancer indications, including GBM. This webinar will be hosted by Tribe Public and feature Panna Sharma, Lantern’s President and CEO. Both LP-184 and LP-284 are currently enrolling patients in Phase 1 trials. Webinar Wednesday will focus on Lantern’s AI-focused collaboration with Actuate Therapeutics, a clinical-stage biopharmaceutical company that went public in August 2024. Andrew Mazar, Ph.D., Chief Operating Officer of Actuate, and Lantern’s computational biologist Joseph McDermott, Ph.D., will discuss the multi-year research and development collaboration that accelerated the development of Actuate’s lead drug candidate, Elraglusib.

On October 15, Lantern Pharma announced that the FDA has granted Fast Track Designation for investigational drug candidate, LP-184, for treatment of Glioblastoma. LP-184 is currently in a Phase 1A clinical trial designed to evaluate the safety and tolerability of the synthetically lethal investigational drug candidate in a broad range of solid tumors, including Glioblastoma (GBM). LP-184 was optimized and advanced in part with Lantern’s AI platform, RADR®, to aid in the validation of mechanisms that could be exploited in the clinical setting to eradicate challenging cancers, and uncover insights in targeted patient populations. RADR® is Lantern’s AI platform for cancer therapy discovery, development and rescue with over 100 billion data points and aiding in the development of both Lantern’s portfolio and development initiatives with Lantern’s collaborators. Fast Track Designation is designed to expedite FDA review of important new drugs to treat serious conditions and fill an unmet medical need. Fast Track Designation for LP-184 (STAR-001) recognizes Glioblastoma (GBM) as a serious condition impacting more than 13,000 U.S. adults each year and approximately 300,000 globally. A phase 1b/2a clinical trial for recurrent GBM is targeted to start in late 2024/early 2025. LP-184, which will be developed as STAR-001 for CNS and other neuro-oncology indications by Starlight Therapeutics, a wholly owned subsidiary of Lantern Pharma, has the potential to be the first new drug for treating GBM in more than 20 years.

On September 23, Lantern announced that the company has been granted three rare pediatric disease designations (RPDD) by the FDA. Lantern was granted these rare pediatric disease designations in: malignant rhabdoid tumors (MRT), rhabdomyosarcoma (RMS), and hepatoblastoma. Rare pediatric diseases are defined by the FDA as serious or life-threatening conditions primarily affecting children under 18, with fewer than 200,000 cases in the U.S. A key benefit of obtaining a RPDD is the potential to receive a priority review voucher following FDA approval of a product with RPDD if the marketing application submitted for the product satisfies certain conditions, including approval prior to September 30, 2026 unless changed by legislation. These vouchers, often called “golden tickets,” can significantly expedite the review process for future NDAs or biologic license applications, reducing the standard review time from about ten months to six. Sponsors can either use these vouchers themselves or sell them to other companies. These vouchers, in the recent past, have commanded sales prices of approximately $100 million USD.

 

Panna Sharma is the President, CEO, and Board Member of Lantern Pharma Inc.

“At Lantern, we’re harnessing AI and data-driven approaches to revolutionize cancer drug development, aiming to dramatically reduce costs, accelerate timelines, and enhance precision in bringing new therapies to patients. Our recent breakthrough in identifying three additional, high-potential indications for LP-184 in pediatric cancers exemplifies this progress. We believe that ‘AI for good’ should address both blockbuster opportunities as well as rare, often overlooked pediatric cases. The FDA’s Rare Pediatric Disease designation for these three potential programs is a testament to this commitment. We’re acutely aware that patients and their families are relying on innovators like us to speed up therapy development. These designations mark a crucial step forward in advancing our expanding portfolio of pediatric programs targeting these devastating and rare cancers. It reinforces our dedication to transforming hope into tangible solutions for those who need them most,” stated Panna Sharma, CEO and President of Lantern Pharma.


Eupraxia Pharmaceuticals (EPRX, $2.58, +2.79% over the last 5-days) is a clinical-stage biotechnology company focused on the development of locally delivered, extended-release products that have the potential to address therapeutic areas with high unmet medical need. The Company strives to provide improved patient benefit and has developed technology designed to deliver targeted, long-lasting activity with fewer side effects. DiffuSphere™, a proprietary, polymer-based micro-sphere technology, is designed to facilitate targeted drug delivery, with extended duration of effect, and offers multiple, highly tuneable pharmacokinetic (PK) profiles. This investigational technology can be engineered for use with multiple active pharmaceutical ingredients and delivery methods.

On October 15, Eupraxia announced that Lancet Rheumatology, a leading independent, peer-reviewed journal committed to sharing progressive content relevant to rheumatology specialists worldwide, recently published Eupraxia’s Phase 2 data from its SPRINGBOARD trial evaluating EP-104IAR for the treatment of knee osteoarthritis. Publication of Eupraxia’s Phase 2b data in Lancet Rheumatology, a distinguished and respected journal, raises the profile of EP-104IAR. As outlined in Lancet Rheumatology, Eupraxia’s EP-104IAR imparts clinically significant and durable pain relief, while also having minimal changes in glucose and cortisol, along with stable fluticasone proportionate concentrations in plasma. The U.S. Centers for Disease Control and Prevention estimates that knee osteoarthritis affects more than 30 million people in the U.S. alone. You may read the Lancet Publication regarding Eupraxia at this link. 

Eupraxia is presented a poster at the United European Gastroenterology (“UEG”) Week 2024 held in Vienna, Austria on October 12-15, 2024.

On September 11, Eupraxia announced additional positive clinical data from its RESOLVE Phase 1b/2a trial, which is evaluating the safety and efficacy of EP-104GI as a treatment for eosinophilic esophagitis (“EoE”). The results announced today from the fourth cohort of the RESOLVE trial, using Eupraxia’s DiffuSphere™ technology for EoE, are derived from twelve 2.5 mg injections of EP-104GI (total dose of 30 mg) administered to less than two-thirds of each patient’s lower esophagus. The data show:

  • Straumann Dysphagia Index (“SDI”)1, a patient-reported outcome measure designed to assess symptom severity, was lower for all three patients post-administration with peak reductions up to four points (67% from baseline). At 12 weeks post-administration, SDI was reduced by a mean of 45% or 3.3 points – a level comparable with currently approved therapies.
  • Eosinophilic Esophagitis Histology Scoring System (“EoEHSS”)2 scores, which evaluate the severity and extent of EoE, showed the largest percent reduction of any cohort to date, with a mean 39% reduction in Composite Stage and a mean 37% reduction in Composite Grade at 12 weeks – a level comparable with currently approved therapies.
  • Using data from four biopsy sites, which is consistent with the U.S. Food and Drug Administration (“FDA”) Guidance for Developing Drugs for the Treatment of EoE, the mean reduction in Peak Eosinophil Counts (“PEC”)3 was 67% at 12 weeks.
 

 

On July 9, a Tribe Public CEO Presentation and Q&A Webinar Event titled Exploring The Rapid Rise Of Osteoarthritis”  was held with James A. Helliwell, MD, Director and Chief Executive Officer of Eupraxia Pharmaceuticals (NASDAQ: EPRX). Please view the event video below:


On Aug. 7, Eupraxia announced its financial results for the second quarter of 2024. Dr. James Helliwell, CEO of Eupraxia stated, “Our eosinophilic esophagitis (“EoE”) clinical program is making excellent progress, as additional safety and efficacy data from our ongoing RESOLVE study continues to suggest that EP-104GI could represent a significant improvement over currently approved therapies for this debilitating condition. In addition, during the second quarter, we presented data at two medical meetings highlighting the potential of our candidate for the treatment of knee osteoarthritis (“OA”), EP-104IAR, which also holds the potential to advance the current standard of care in OA. “Looking ahead, we anticipate reporting new data from the fourth cohort of the RESOLVE study in the near term and we continue to engage prospective partners for possible licensing of the EP-10IAR program. We look forward to engaging with the U.S. Food and Drug Administration in the fourth quarter of 2024 on the EP-104GI program and potentially expanding our gastrointestinal trials into the U.S. With two clinical-stage assets each having the potential to represent a meaningful improvement over currently approved therapies, we believe Eupraxia remains well positioned to create shareholder value.” Learn more here. 

On Aug. 2, Eupraxia announced entry into a new C$12 million convertible debt facility. Under the Convertible Debt Facility, Yabema Capital Limited and other current Eupraxia shareholders (together, the “Lenders”) will make available for drawdown an aggregate amount of C$12 million for a period of 120 days following entry into the agreement. The decision to draw on the facility within 120 days of closing is at the discretion of Eupraxia and is subject to the full and final release of the SVB Facility (as defined below), originally agreed to on June 21, 2021. The aggregate unpaid principal amount and any accrued and unpaid interest thereon will be convertible at each individual lender’s discretion into Eupraxia common shares (the “Common Shares”), at a conversion price equal to C$4.84375 per Common Share. The conversion is further subject to certain threshold limitations with respect to each lender’s aggregate ownership of the Common Shares. “The new convertible debt facility provides an important source of additional funding from long term, supportive investors, and creates greater stability to Eupraxia’s cap structure as we continue to advance our clinical programs in eosinophilic esophagitis and osteoarthritis,” said Dr. James Helliwell, Chief Executive Officer of Eupraxia. The Convertible Debt Facility is subject to final approval of the Toronto Stock Exchange.

 

Shares of ADT Inc. (ADT), a leading provider of monitored security and automation solutions for residential and small business customers in the United States and Canada, closed at $7.88, up +11.14%  over the last 5-days after reporting results for the third quarter of 2024 that beat the street’s estimates and highlighting the following: Continued strong financial results, cash generation, and leverage reduction, Revenue up 5% versus prior year period, GAAP income from continuing operations up 7%; Adjusted EBITDA up 6%, Record-high recurring monthly revenue; solid customer retention, & On track to achieve full year 2024 guidance metrics.

 

Sabres of Rocket Lab USA, Inc. (Nasdaq: RKLB) closed at $11.18, +3.42% over the last 5-days and +102.17% YTD), a global leader in launch services and space systems, recently announced it has added a last-minute Electron launch to its launch manifest for a commercial mission that is scheduled to launch in just three days’ time. The mission, called ‘Changes In Latitudes, Changes In Attitudes’, will launch to space from Rocket Lab Launch Complex 1 during a launch window that opens October 19th for a confidential commercial customer. The expedited mission will be Rocket Lab’s fastest turnaround to date: from signed contract to launch date in less than two months.

QUOTE OF WEEK


“The less we deserve good fortune, the more we hope for it.” – Lucius Annaeus Seneca

Investing & Inspiration

  1. “The less we deserve good fortune, the more we hope for it.” – Lucius Annaeus Seneca
  2. “Art is the right hand of Nature. The latter has only given us being, the former has made us men.” – Friedrich Schiller
  3. “To begin, begin.” –  William Wordsworth
  4. “Nature does not hurry, yet everything is accomplished.” – Lao Tzu
  5. “The end of labor is to gain leisure.” – Aristotle
  6. “People are not disturbed by things, but by the view they take of them.” – Epictetus
  7. “Have patience. All things are difficult before they become easy.” – Saadi
  8. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  9. “The traveler sees what he sees, the tourist sees what he has come to see.” – Gilbert K. Chesterton
  10. “The only true wisdom is in knowing you know nothing.” – Socrates
  11. “Courage is knowing what not to fear.”– Plato
  12. “The home is the chief school of human virtues.” – William Ellery Channing
  13. “Be brave. Take risks. Nothing can substitute experience.” – Paulo Coelho
  14. “There are no shortcuts in evolution.” – Louis D. Brandeis
  15. “A friend may well be reckoned the masterpiece of nature.” –  Ralph Waldo Emerson
  16. “Nature uses as little as possible of anything.” – Johannes Kepler
  17. “Every new beginning comes from some other beginning’s end.” – Seneca
  18. “Nothing ever becomes real till it is experienced.” – John Keats
  19. “Nobody who ever gave his best regretted it.” – George Halas
  20. “Honest disagreement is often a good sign of progress.” – Mahatma Gandhi
  21. “A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell
  22. “They always say time changes things, but you actually have to change them yourself.” – Andy Warhol
  23. “The secret of happiness is something to do.” – John Burroughs
  24. “The world of reality has its limits; the world of imagination is boundless.”
  25. “You begin with the possibilities of the material.” – Robert Rauschenberg
  26. “The only Zen you can find on the tops of mountains is the Zen you bring up there.” – Robert M. Pirsig
  27. “Leadership is the capacity to translate vision into reality.” – Warren Bennis
  28. “A man should always consider how much he has more than he wants.” – Joseph Addison
  29. “Happiness is good health and a bad memory.” –  Ingrid Bergman
  30. “We pass through this world but once.” – Stephen Jay Gould
  31. “Christmas waves a magic wand over this world, and behold, everything is softer and more beautiful.” – Norman Vincent Peale
  32. “Nothing can have value without being an object of utility.” – Karl Marx
  33. “Always turn a negative situation into a positive situation.” – Michael Jordan
  34. “Courage is found in unlikely places.” – J. R. R. Tolkien
  35. “One that would have the fruit must climb the tree.” – Thomas Fuller
  36. “Someone is sitting in the shade today because someone planted a tree a long time ago.” – Warren Buffett
  37. “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes
  38. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” – George Bernard Shaw
  39. “Everything in the world may be endured except continual prosperity.”  – Johann Wolfgang von Goethe
  40. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
  41. “Time is money.” – Benjamin Franklin
  42. “Change before you have to.” – Jack Welch
  43. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
  44. “The Universe is under no obligation to make sense to you.” – Neil deGrasse Tyson
  45. “Care and diligence bring luck.” – Thomas Fuller
  46. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
  47. “A man who is a master of patience is master of everything else.” – George Savile
  48. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
  49. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
  50. “Act as if what you do makes a difference. It does.” – William James
  51. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
  52. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
  53. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
  54. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
  55. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
  56. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
  57. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
  58. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
  59. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
  60. “Action is the foundational key to all success.” – Pablo Picasso
  61. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
  62. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
  63. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
  64. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
  65. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
  66. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
  67. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
  68. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
  69. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
  70. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
  71. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  72. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
  73. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
  74. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
  75. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
  76. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
  77. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  78. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  79. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
  80. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
  81. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  82. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
  83. “No man was ever wise by chance.” – Lucius Annaeus Seneca
  84. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  85. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  86. “It does not matter how slowly you go as long as you do not stop.” – Confucius

  87. “I want to put a ding in the universe.” – Steve Jobs

  88. “Research is creating new knowledge.” – Neil Armstrong

  89. “The reward for work well done is the opportunity to do more.” – Jonas Salk
  90. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
  91. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey
  92. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

  93. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger
  94. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

  95. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

  96. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain
  97. “The best way out is always through.” – Robert Frost

  98. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi
  99. “Without labor nothing prospers.” – Sophocles

  100. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein
  101. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

  102. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

  103. “He who is brave is free.” – Lucius Annaeus Seneca
  104. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

  105. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

  106. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

  107. “He who knows that enough is enough will always have enough.” – Lao Tzu

  108. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall
  109. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

  110. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
  111. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  112. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
  113. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
  114. “You must do the things you think you cannot do.”- Eleanor Roosevelt
  115. “Success is dependent on effort.” – Sophocles
  116. “Nobody who ever gave his best regretted it.” – George Halas
  117. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
  118. “And when I breathed, my breath was lightning.” – Black Elk
  119. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
  120. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
  121. “If you want a guarantee, buy a toaster.” – Clint Eastwood
  122. “We are an impossibility in an impossible universe.” – Ray Bradbury
  123. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
  124. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
  125. Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
  126. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
  127. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
  128. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
  129. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
  130. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
  131. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
  132. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
  133. “There is more to life than increasing its speed.” – Mahatma Gandhi
  134. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
  135. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
  136. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
  137. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
  138. “Life is too short for long-term grudges.” – Elon Musk
  139. There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
  140. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
  141. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
  142. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
  143. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
  144. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
  145. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
  146. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  147. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
  148. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  149. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
  150. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  151. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
  152. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
  153. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
  154. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
  155. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
  156. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
  157. “Delete the negative; accentuate the positive!” – Donna Karan
  158. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
  159. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
  160. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
  161. “Everything has beauty, but not everyone sees it.” – Confucius
  162. A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
  163. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
  164. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
  165. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  166. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  167. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
  168. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  169. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
  170. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  171. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
  172. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
  173. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
  174. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
  175. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
  176. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  177. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
  178. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
  179. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
  180. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  181. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  182. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
  183. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
  184. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
  185. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
  186. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
  187. “Never do anything against conscience even if the state demands it.”– Albert Einstein
  188. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  189. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
  190. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  191. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  192. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
  193. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
  194. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
  195. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
  196. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
  197. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
  198. “The secret of getting ahead is getting started.” – Mark Twain
  199. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe