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Nasdaq Strongly Rebounds As Tesla, Alphabet, & NVIDIA Jump Double Digits This Week – $ADT $AAPL $ARKK $GOOG $IBRX $IWC $NVDA $SHIP $TSLA Rise!

By John F. Heerdink, Jr.
Quote of the Day: “Nobody who ever gave his best regretted it.” – George Halas




Happy Saturday!

I hope that you all had a successful week and are out and about enjoying your weekend. 

As for the broad stock market, equities overall closed higher this week with the Nasdaq and the Magnificent 7 stocks leading the weigh with overall significantly over-weighted and double digit moves in the some cases, while the CBOE Volatility Index (^VIX) fell over the course of the week down 11.38 to close at $15.03.

Continuing to fuel interest rate related fears, if not cement the fact the Fed will be pushing back the timeline on any interest rate cuts, the US macroeconomic schedule offered a number of reports including on Tuesday, the preliminary S&P Global U.S. Manufacturing PMI report for April that showed a drop below the expansion line coming in at 49.9 and nearly a 2 point drop since March, The preliminary S&P Global U.S. Services PMI report also dropped to 50.9. However, the New home sales report closed in with a 8.8% M/M rise in March to a seasonally adjusted annual rate of 693k units & on a Y/Y basis, new home sales also proved to pop by 8.3%. On Wednesday, the Weekly MBA Mortgage Applications Index report came at -2.7%. The March Durable Orders report also came in higher than expected at 2.6%, while the March Durable Goods, sans transportation, closed in at .2%. The Weekly EIA Crude Oil Inventories report also rang in with a 6.37M barrel draw. On Thursday, the Advanced Q1 GDP report clocked in lower than expected 1.6%, thus confirming a period of slowing growth combined with higher prices. The macroeconomic schedule also provided the March Advanced International Trade in Goods report that came in at-$91.8B. The March Advanced Retail Inventories report clocked lower at .3%, while the March Advanced Wholesales Inventories report came lower at -.4%. The Weekly Initial Claims report clocked in lower than expected at 207k, while the Weekly Continuing Claims report was a 1.781M. The March Pending Home Sales report also came above expectations at 3.4%. On Friday, the March Personal Income report came in as expected at .5%, while the March Personal Spending report came in above expectation at .8%, &  March PCE Prices came as expected at .3%. Finally, the Final April University of Michigan Consumer Sentiment clocked in lower than expected at 77.2.

In turn, the yield curve moved higher again this week as the 10-yr note yield rose 5bps to 4.62% & the 2-yr note yield moved up 3bps to 5%. Interestingly, Oil prices also rose to close at $83.65/bbl,+1.7%, & are now up 16.7% YTD. The U.S. Dollar Index also moved slightly lower from 106.11 to 106.09. 

At the end of the week, the Dow 30 actually closed at 38,240 (+.7%) this week and is now up just 1.5% YTD.  

The S&P 500 closed at 5,100 (2.7%) and is now up 6.9% YTD. 11 of the 11 sectors closed in the green with the information technology sector (+5.1%), the consumer discretionary sector (+3.5%), & the communication services sector (+2.7%) leading all. Note that about 1/3 of the S&P 500 companies reporting earnings have reported so far and nearly 80% of the companies beating expectation by ~10%.

The Nasdaq closed at 15,928 (+4.2%) and is now up 6.1% YTD. The overweighted Magnificent Seven closed across the board as follows over the last 5-days: Alphabet (GOOG) closing at $173.69, +11.54%, Amazon (AMZN) closing at $179.62, +2.86%, Apple (AAPL) at $169.30, +2.61%, Meta Platforms (META) closing at $443.29, -7.85%, Microsoft (MSFT) closing at $406.32, +1.80%, NVIDIA (NVDA) closing at $877.35, +15.14% as some of the chip giant’s customer base are investing further in their artificial intelligence endeavors, & Tesla (TSLA) closing at $168.29, +14.44% also popped post confirming that they would moving swiftly forward with their next-generation platform of sub-$30k mainstream EV-dubbed the Model 2. Note that profits for the Magnificent Seven are currently forecasted to increase by 47% in Q1 over a year ago. Tesla, Alphabet, Microsoft, reported this exceeding expectations & Meta failed to do so as they are having to invest more than was previously expected in their AI offering. Alphabet also added a cash dividend of $.20/share and approved a stock repurchase of up to $70B. 

The small caps on the Russell 2000 closed at 2,002.00 (+2.79%) for the week & is now down -1.24% YTD, while the MicroCaps closed higher this week as the iShares Micro-Cap ETF (IWC) closed at $112.63, +2.20% over the week.

Bank stocks on The SPDR S&P Regional Banking ETF (KRE) moved up to close at $48.19, +1.84% over the last 5-days & the SPDR S&P Bank ETF (KBE) moved up over the last 5-days to close at $45.33, +2.07% this week.  

Overall, The Nasdaq Biotechnology ETF (IBB) closed at $126.49, +1.42%, the NYSE ARCA Biotech Index (^BTK) closed at 4,939.03, +1.51% & the SPDR S&P Biotech ETF (XBI) closed at $83.49, +.80% over the last 5-days. The iShares U.S. Healthcare ETF (IYH) closed at $58.61, +.77% over the last 5-days.  

Cathie Wood’s ARK Innovation ETF (ARKK) closed at $44.07, +4.93% over the last 5-days.

From the world of cryptocurrency, Bitcoin (BTC) moved to 63,975.24, -4.28% over the course of the last 5-days at the time of the completion of this message.

Gold prices closed at $2,336 down from $2,395 over the last 5-days. The SPDR Gold Shares (GLD) closed at $216.62, -2% over the past 5-days and is up 17.26% over the last year. Silver prices closed at $27.22 up from $28.61/oz. The Global X Silver ETF (SIL) closed at $31.95, +1.72% over the last 5-days.  




VP Watchlist Updates


ImmunityBio, Inc. (NASDAQ: IBRX, $7.35, +39.47% over the last 5-days), an immunotherapy company, announced (April 25) positive overall survival results in the QUILT 3.055 study of 2nd- and 3rd-line NSCLC patients who progressed after checkpoint inhibitor therapy (pembrolizumab, nivolumab, or atezolizumab) and standard-of-care chemotherapy. The results continue to reinforce ImmunityBio’s belief in the unique mechanism of action of ANKTIVA (N-803, or nogapendekin alfa inbakicept-pmln) and its potential efficacy as a next-generation immunotherapy across multiple solid and liquid tumor types. In NSCLC patients who relapsed or were refractory to checkpoint inhibitors, ANKTIVA was administered together with the same checkpoint inhibitor. The addition of ANKTIVA resulted in the rescue of the checkpoint therapy efficacy, with significant prolongation of overall survival. These positive results were noted regardless of the patient’s PD-L1 status, consistent with the mechanism of action of ANKTIVA in activating and proliferating natural killer cells, and stimulating CD8+ Killer Memory T cells. This prolongation of survival in NSCLC following checkpoint failure is consistent with ImmunityBio’s findings of durable complete responses following BCG failure in NMIBC. A meeting with the FDA has been scheduled for June to discuss the company’s overall survival results in PD-L1 negative and positive patients and registration plans for 2nd-line and 3rd-line NSCLC patients whose cancer did not respond or continue to respond to checkpoint therapy and for whom few alternative therapies are available. The company further sighted the following:

  • QUILT 3.055 trial completed and shows median overall survival almost double that of standard of care chemotherapy in 2nd– and 3rd-line non-small cell lung cancer (NSCLC) patients whose cancer did not respond to checkpoint inhibitors with or without chemotherapy

  • Positive results seen in both PD-L1 negative and PD-L1 positive participants with NSCLC

  • Data reaffirms the mechanism of action of ANKTIVA as an immune cell enhancer that activates natural killer (NK) cells and memory T cells to rescue checkpoint inhibitor (pembrolizumab, nivolumab, atezolizumab) failures across multiple tumor types

  • Meeting scheduled with FDA in June to discuss path to registration filing of ANKTIVA plus checkpoint inhibitors in 2nd– and 3rd-line NSCLC patients whose cancer previously did not respond to checkpoint therapy

  • $100 million in non-dilutive cash infusion with ANKTIVA approval brings cash-on-hand to approximately $240 million for launch of ANKTIVA in non-muscle invasive bladder cancer (NMIBC)


 
 
Modular Medical, Inc. (NASDAQ: MODD, $1.58, -3.07% over the last 5-days and up +49.06% over the last 6-months), is a development-stage medical device company that intends to launch the next generation of insulin delivery technology. Using its patented technologies, the company seeks to eliminate the tradeoff between complexity and efficacy, thereby making top quality insulin delivery both affordable and simple to learn. Their mission is to improve access to the highest standard of glycemic control for people with diabetes taking it beyond “superusers” and providing “diabetes care for the rest of us.” Modular Medical was founded by Paul DiPerna, a seasoned medical device professional and microfluidics engineer. Prior to founding Modular Medical, Mr. DiPerna was the founder (in 2005) of Tandem Diabetes and invented and designed its t:slim insulin pump. More information is available at https://modular-medical.com.
 
 
 
Note that Jeb Besser, CEO, of Modular Medical will be presenting at two of our sister organization’s Tribe Public Presentation and Q&A Luncheon and Dinner Events on April 30 and will present Revolutionizing Diabetes Care” ] in Nashville, Tennessee. If you will be in the area, then let me know and I will try to find you a seat and introduce you to Jeb.
 

On Feb. 21, Modular Medical announced the closing of its previously announced underwritten public offering (the “offering”) of 9,090,910 shares of its common stock, led by Manchester Explorer, L.P., which is managed by Jeb Besser, Modular Medical’s Chief Executive Officer, and Morgan Frank, a member of the Company’s board of directors, and other existing institutional investors. Each share of common stock was sold at a price to the public of $1.10 per share. The gross proceeds to Modular Medical from this offering were approximately $10 million, before deducting underwriting discounts and commissions and other offering expenses payable by the Company. The Company intends to use the net proceeds from the offering to fund operations and for working capital and general corporate purposes, including capital expenditures. In addition, Modular Medical has granted the underwriters a 30-day option to purchase up to an additional 1,321,989 shares of common stock to cover over-allotments, if any.Titan Partners Group, a division of American Capital Partners, acted as sole book-running manager for the offering.

On Jan. 24, Modular Medical announced the issuance of U.S. Patent 11,817,197 B2 for the stream-lined pairing of a pump to a mobile device. Paul DiPerna, Chairman and CTO of Modular Medical, commented, “The issuance of this patent is just another step in our mission to use technology to rethink and simplify the adoption of and ability to live with pump technology for patients and caregivers. To address cybersecurity risks and the complexity of pairing multiple devices to talk between a phone and a pump, we added Near-Field Communication (NFC), whereby, just by bringing the phone close to our pump will create a secure connection making it much easier to develop, test and maintain. This patent protects our technology addressing pairing, and, most importantly, the downloading of patient data to allow clinicians to easier upload and review the patients data. The patient’s phone is not required, and a clinician can simply tap the pump to the phone or tablet to pull the data using Bluetooth from patient pumps. In a high-volume practice, such as a busy certified pump trainer’s office, the ability to pull data from several patients quickly is critical. Our patented technology addresses the ability to do this without the tedious step of powering on and pairing with a myriad of new Bluetooth devices. It also simplifies moving the configuration to a new reusable controller, when needed, without using an intermediate device.” Jeb Besser, Modular Medical’s CEO, commented, “Our family of patents, which includes both issued patents and pending applications, around our pump is an important part of our strategic value and market positioning, and we look forward to announcing further patent issuances in the future.”
 
On Jan. 19, Modular Medical announced the premarket submission of its MODD1 next-generation insulin pump to the FDA for 510(k) clearance. “This is an exciting milestone for the Company, as we seek to change the diabetes market. Almost 30 years after the introduction of the first insulin pump, more than three quarters of those who could benefit from wearing a pump do not wear one. It is our belief that our simplified design will encourage many “almost-pumpers” to adopt technology to aid in their diabetes management, without the complexity and expense required by many of the current solutions,” said Paul DiPerna, Chairman and CTO of Modular Medical.
 
On Dec. 21, Modular Medical announced a collaboration agreement with Glooko, Inc., a global leader specializing in connected care and remote patient monitoring for diabetes. Integrating with Glooko will allow clinicians and patients to easily review insulin dosing data from the MODD1 pump, when commercially available. In addition, through Glooko’s platform, Dexcom CGMS users will be able to view their glucose levels in the same accessible format in conjunction with their pump data. Glooko’s platform has a broad installed base, which has been deployed in over 30 countries and 8,000 clinical locations. Jeb Besser, CEO of Modular Medical stated, “We are extremely pleased to add the Glooko technology platform to our diabetes care system making it even easier and more cost effective for us to provide this important capability to our clinical and patient base. Glooko’s mission to improve health outcomes of people with chronic conditions through its personalized, intelligent, connected care platform fits perfectly with our vision of providing an easy to use, affordable delivery technology to give more patients access to better care.”
 


Lantern (LTRN) closed at $5.50, up +3% over the last 5-days and +28.50% YTD.  Lantern is an Artificial Intelligence (AI) firm that is transforming the cost, pace, and timeline of oncology drug discovery and development and specifically is developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs.

On March 18 after the close, Lantern announced operational highlights and financial results for the fourth quarter and fiscal year ended December 31, 2023. Panna Sharma, President and CEO of Lantern Pharma started, “This past quarter and the entire year of 2023 was a period of meaningful and remarkable progress for our programs and our AI platform at Lantern Pharma. Our team demonstrated how combining emerging AI technologies, cancer biology models and experiments, chemical, molecular, and multiomic biomarker data, along with large-scale patient data holds the promise of transforming timelines and costs in drug development for oncology. We are very enthusiastic about 2024 and will be actively focused on meeting and possibly exceeding the milestones ahead of us, which include potential initial data from our LP-184 Phase 1A trial; advancing the new company born from AI – Starlight Therapeutics, which is focused wholly on CNS cancers; and progressing our ADC oncology program. Computational and AI-driven approaches are increasing their value-driving impact on oncology drug development, and our team continues to increase the capabilities and usefulness of our platform while also helping to de-risk and sharpen the focus of our existing clinical drug candidates. Our leadership in the innovative use of AI and machine learning to transform costs and timelines in the development of precision oncology therapies has guided three drug development programs in active clinical trials. We believe this pace of development with our focused team and resources should yield significant future benefits for investors and patients as our industry matures, adopts and accepts a data and AI-centric approach to drug development.”

On March 15, Lantern announced the dosing of the first two patients in the Phase 1 clinical trial evaluating Lantern’s investigational new drug LP-284 in patients with relapsed or refractory non-Hodgkin’s lymphoma (NHL), including mantle cell lymphoma (MCL) and double hit lymphoma (DHL) and other high-grade B-cell lymphomas (HGBL) as well as other select solid tumors and sarcomas. Recently, Lantern Pharma’s AI platform, RADR® is expected to exceed 100 billion data points during 2024, and has been crucial in uncovering and accelerating indications for LP-284 as well as other drug-candidates that are in development.


Watch “How AI Has Lit A Revolution In Healthcare, Medicine, & Human Longevity”  on The Tribe Public Channel as Panna Sharma CEO Lantern Pharma was interviewed on Feb. 29.

On Feb. 15, Lantern announced an important milestone in its antibody-drug conjugate (ADC) program. In collaboration with Bielefeld University, Lantern has generated a new class of highly specific and highly potent ADCs with a cryptophycin drug-payload. This novel approach utilizes cysteine-engineered antibodies which allows for the development of uniform and homogenous ADCs with precise control of the drug to antibody ratio (DAR). The drug-payload, cryptophycin, has the potential to improve upon existing ADCs used in the clinical setting by: 1) improving the anti-tumor potency of the ADC molecule, and 2) overcoming drug resistance tumors can frequently develop to existing drug-payloads such as MMAE (Monomethyl auristatin E). The cryptophycin drug-payload and cryptophycin-ADC (CpADC) averaged an 80% cancer cell kill rate across the tested cancer cell lines and significantly outperformed MMAE. In a broad range of preclinical studies, the cryptophycin-ADC (Cp-ADC) demonstrated promising picomolar level potency and anti-tumor activity in a wide range of solid tumors, including six cancer indications that are being further evaluated. These six indications include: breast, bladder, colorectal, gastric, pancreatic and ovarian cancer. Initial results (Figure 1) have also shown that in high Her2 expressing tumors, Cp-ADC with a DAR of 8 (Tras(C8)-Cp) and DAR of 4 (Tras(C4)-Cp) is more potent than an MMAE ADC with a DAR of 8. MMAE payloads are used in several commercially available anti-cancer ADCs, including Adcetris®, Polivy® and Enhertu®. Additionally, the Cp-ADC with a lower DAR (Tras(C2)-Cp) provides an equivalent tumor kill-rate to that of an MMAE-ADC with a DAR of 8. In a moderate Her2 expressing cell line, the Cp-ADC with a DAR of 8 (Tras(C8)-Cp) was about 10 times more potent than a DAR 8 MMAE-ADC. The newly developed Cp-ADC showed highly efficient anti-tumor activity in all six cancer cell lines with EC-50 values in the picomolar to single-digit nanomolar range. Additional studies are now being developed to further validate and expand these findings and to obtain a better understanding of the genomic and biomarker correlates of payload efficacy across these tumors.

Kishor Bhatia, Ph.D., Lantern’s Chief Scientific Officer commented, “Our strategic, data-driven approach of utilizing cryptophycin as a highly potent and novel payload alongside the prioritization of biologically novel and relevant targets with scalable and efficient drug conjugate formats will help expand the repertoire and diversity of ADC opportunities.”

Lantern is also utilizing its AI platform, RADR® to further refine and understand other cancer targets, with a focus on prioritizing targets that are expressed across multiple tumor types or subtypes and have few or no therapeutic ADC options. Given the promise of cryptophycin as a payload, Lantern is also focused on the development and testing of two other cryptophycin-ADC molecules. For these selected targets, Lantern is in advanced discussions with potential partners and collaborators with the goal of generating proof-of-concept data for these additional ADCs and potentially other novel drug conjugate formats. Lantern expects to provide additional details on these studies and collaborations in the coming quarters. These efforts aim to improve ADC development for specific patient populations and potentially guide more effective future clinical treatments with less cost and greater efficiency than historical ADC drug development.

On Jan. 17, Starlight Therapeutics— a Lantern Pharma (Nasdaq: LTRN) subsidiary focused exclusively on the clinical development of therapies for central nervous system and brain cancers with limited or no effective therapeutic options— announced that Marc Chamberlain, M.D. has joined Starlight as its Chief Medical Officer. Dr. Chamberlain will oversee Starlight’s clinical operations, which currently include planned clinical trials for glioblastoma and other high-grade gliomas, brain metastases in adults, and atypical teratoid rhabdoid tumors (ATRT), and diffuse pontine glioma (DIPG) in children. In his role, Dr. Chamberlain will apply his significant medical, clinical, and pharmaceutical development expertise to advance Starlight’s AI-enabled and accelerated drug development portfolio. Dr. Chamberlain is a leading medical oncologist with an extensive and distinct background in therapeutic development, clinical practice, and academic research with a focus in adult and pediatric neurology and neuro-oncology. His experience before joining Starlight has included serving as the co-director of the neuro-oncology programs at 4 NCI designated cancer centers— Moores Cancer Center at UC San Diego, Norris Cancer Center at USC, Moffit Cancer Center at the University of South Florida, and Fred Hutchinson Cancer Center at the University of Washington. He has also served as medical director for Cascadian Therapeutics, Seattle Genetics, SystImmune, Angiochem, and Pionyr Immunotherapeutics. Dr. Chamberlain has published more than 300 neurology-focused papers in peer-reviewed journals. “Starlight Therapeutics and Lantern Pharma are poised to transform oncology with AI-enabled drug development aimed at providing advanced precision therapeutics for cancers in areas of severely unmet need, such as multiple types of pediatric and adult brain cancers, for which there is currently no cure,”said Panna Sharma, CEO and President of Lantern Pharma. “Dr. Chamberlain’s insight and expertise in neuro-oncology and therapeutic development will be invaluable to the further development of treatments already in the pipeline, and the discovery and development of new future treatments that are so desperately needed by cancer patients, especially in neuro-oncology.” Dr. Chamberlain earned his medical degree at the Columbia University College of Physicians and Surgeons, followed by pediatric and neurology residencies at the University of California, Los Angeles, and a neuro-oncology fellowship at the University of California, San Francisco. “Starlight, in collaboration with Lantern Pharma, is poised to advance its novel central nervous system (CNS) penetrant wholly synthetic acylfulvene, LP-184 (referred to as “STAR-001″ for CNS indications), to target tumors in the brain. We are now preparing for two recurrent glioblastoma studies as part of a larger planned expansion study to assess STAR-001 in subjects who have failed standard-of-care temozolomide and involved field radiotherapy. The development of STAR-001 for use in brain tumors has utilized Lantern’s proprietary RADR® platform of in silico modeling as well as extensive preclinical experimentation in multiple in-vitro and in-vivo models,” said Dr. Chamberlain. “I’m looking forward to working alongside the talented researchers and experts at Lantern and its collaborators at Starlight who have already done so much to advance these treatments. I look forward to working together with our collaborators and clinicians to bring these and many more innovative neuro-oncology treatments to the patients who need them.” Formed in Q1 of 2023, Starlight Therapeutics is leveraging RADR®— Lantern Pharma’s proprietary artificial intelligence and machine learning platform focused on transforming the cost, pace and timeline of oncology drug discovery and development— to research, develop and clinically advance therapeutics for CNS and brain cancers.


Shares of Indaptus Therapeutics, Inc. (Nasdaq: INDP), a clinical stage biotechnology company dedicated to pioneering innovative cancer and viral infection treatments, closed at  $2.10.59% over the last 5-days and up 19.89% YTD. 

Indaptus’ CEO, Jeffrey Meckler presented a corporate overview at the MedInvest Biotech & Pharma Investor Conference. The conference is being held on April 3 – 4, 2024 at Cooley Law, 55 Hudson Yards, New York, NY 10001.

On April 11, Indaptus announced it was proud to unveil its poster at the 2024 Annual Meeting of the American Association for Cancer Research (AACR) in San Diego on Wednesday, April 10th. The poster details mechanism of action data that demonstrates the Company’s Decoy platform successfully induces, matures or activates multiple immune cell types involved in anti-tumor responses. The latest findings significantly enhance the Company’s understanding of its “Decoy” platform technology, which uses killed, non-pathogenic bacteria engineered to activate the immune system to attack tumors. The study highlights the platform’s effectiveness in engaging key innate and adaptive immune cells, including, natural killer cells, natural killer T cells, dendritic cells, CD4+, and CD8+ T cells. In some settings, the platform also produced additive or synergistic activity in combination with IL-2, an approved cancer drug. Additionally, the data reveal that the Decoy platform may not only boost the immune system’s ability to recognize and kill tumor cells, but potentially also overcome a mechanism that suppresses the immune response. The results suggest that the Company’s Decoy bacteria can both directly and indirectly prime the immune system to more effectively fight cancer. Jeffrey Meckler, Indaptus’ Chief Executive Officer, added, “We are encouraged by the promising results observed in our preclinical studies and our ongoing Phase 1 clinical trial. The recognition and validation from prestigious organizations such as the AACR, coupled with the support and insights we are receiving from medical experts, partners and investors at the conference, inspire us to continue advancing our technology and demonstrating its significant therapeutic potential for the treatment of solid tumors.” The full poster can be accessed on the Indaptus Therapeutics website by clicking here.

Dr. Michael Newman, Indaptus’ Founder, Chief Scientific Officer, and lead author, commented, “The new data are consistent with our preclinical animal tumor model studies and provide evidence for our hypothesis that patented Decoy bacteria can activate a wide range of innate and adaptive human immune cells involved in fighting tumors. This aligns with what we’ve observed in our ongoing Phase 1 clinical trial of Decoy20 – broad immune activation, as evidenced by transiently increased levels of many key cytokines and chemokines following single dose administration. These findings bolster our confidence in Decoy20’s potential as a multifaceted immunotherapy.”


The Company recently initiated the multi-dose cohort of its Phase 1 clinical trial in solid tumors. Learn more by clicking here!


Indaptus CEO presented in an open Q&A on Tribe Public’s Webinar titled, “Fully Engaging The Human Immune System To Cure Disease” on Wednesday, March 20, 2024. You can now watch the event video at the Tribe Public YouTube Channel at this link

On March 13, Indaptus  announced financial results for the fourth quarter and fiscal year ended December 31, 2023 and provided a corporate update. Jeffrey Meckler, Chief Executive Officer of Indaptus, commented, “We are thrilled with the progress we made in 2023, which was capped off in November when we announced that our lead candidate, Decoy20, demonstrated a broad immune response in patients following a single dose in the first cohort of our ongoing phase 1 study. More recently, in March 2024, we announced positive results from our second cohort. In close consultation with an independent Safety Review Committee, we are now initiating a multi-dose cohort. Our objective in this next part of the Phase 1 trial is to determine the safety of Decoy20, with multiple doses administered to the same patient, which we believe could also potentially enhance anti-tumor activity across various tumor types. As we are encouraged by these initial findings and by the anti-cancer activity we observed from multi-dosing in our pre-clinical models, we look forward to continuing our efforts to demonstrate safety and efficacy. We remain prudent in managing our cash position and furthering our research in a cost effective and efficient manner.”

Indaptus’ CEO Jeffrey A. Meckler, and Nir Sassi, Chief Financial Officer, presented a corporate update at the 2024 BIO CEO & Investor Conference. The conference is being held on February 26 – 27, 2024 at the New York Marriott Marquis.

On Jan. 4, Indaptus announced that the European Patent Office (EPO) has informed the company that it will grant a European patent related to the company’s platform technology, covering a composition that can be used in the prevention or treatment of viral infections. The patent, titled “Methods of Treatment of Infections Using Bacteria,” (Application 19 866 580.4) provides protections for the application of the Company’s Decoy technology platform alone or in combination with standards of care for the prevention or treatment of any viral infection. The EPO patent will be the second patent granted to Indaptus outside the United States for this application. Jeffrey Meckler, Indaptus Therapeutics CEO, commented, “The continued protection of our intellectual property both in the U.S. and abroad will provide a competitive advantage for the Company, which should ultimately drive significant shareholder value over time. We continue to explore the applications of our technology platform beyond solid tumors, for which we are currently engaged in a Phase 1 clinical trial, and look forward to updating our shareholders on scientific progress.”


Learn more about Indaptus Therapeutics (NASDAQ: INDP) at the VP Watchlist page by clicking here.
 

 

 

Shares of ADT Inc. (ADT), the most trusted brand in smart home and small business security, closed at $6.43, +3.88% over the last 5-days. On April 25, ADT report their Q1 earnings results highlighting the following:  

  • Total revenue of $1.2 billion with end-of-period recurring monthly revenue (RMR) up 3% to $353 million ($4.2 billion on an annualized basis)
  • Consumer and Small Business (CSB) revenue of $1.2 billion, up 5% and segment Adjusted EBITDA of $638 million, up 8%
  • Strong customer retention with gross revenue attrition of 13.1%
  • GAAP income from continuing operations of $92 million, or $0.10 per diluted share, up $218 millionAdjusted income from continuing operations of $151 million, or $0.16 per diluted share, up $56 million

On March 6, ADT announced the pricing of a secondary public offering of 65,000,000 shares of the Company’s common stock held by certain entities managed by affiliates of Apollo Global Management, Inc. (the “Selling Stockholders”) at a price to the public of $6.50 per share. The offering is expected to close on March 11, 2024, subject to satisfaction of customary conditions.The underwriters will have a 30-day option to purchase up to an additional 9,750,000 shares of common stock from the Selling Stockholders. The Company is not selling any shares and will not receive any proceeds from the offering. In addition, ADT has authorized the concurrent purchase from the underwriters of 15,000,000 shares of common stock as part of the secondary public offering (the “Share Repurchase”) subject to the completion of the offering. The Share Repurchase is part of the Company’s existing $350 million share repurchase program. The underwriters will not receive any underwriting fees for the shares being repurchased by the Company. Morgan Stanley, Barclays, Apollo Global Securities and RBC Capital Markets are acting as book-running managers for the offering. BNP PARIBAS, Deutsche Bank Securities, Mizuho, Goldman Sachs & Co. LLC, MUFG, BMO Capital Markets, BTIG and Raymond James are acting as joint book-runners for the offering. Berenberg, Fifth Third Securities, Academy Securities, Bancroft Capital and Siebert Williams Shank are acting as co-managers for the offering.


Shares of Seanergy Maritime Holdings Corp. (SHIP), the only pure-play Capesize ship-owner publicly listed in the U.S. closed at $9.57, +2.79% over last 5-days. Seanergy is known as a leading player in the global shipping industry, being the only pure-play Capesize ship owner publicly listed in the U.S. The company specializes in Capesize shipping, representing the largest dry bulk carriers globally. Seanergy’s operating fleet currently consists of 17 vessels (1 Newcastlemax and 16 Capesize), with an average age of approximately 12.7 years and an aggregate cargo-carrying capacity of approximately 3,054,820 deadweight tons (dwt). The company is incorporated in the Marshall Islands and has executive offices in Glyfada, Greece.

 On March 15, Seanergy announced its financial results for the fourth quarter and twelve months ended December 31, 2023. The Company also declared a regular quarterly cash dividend of $0.025 per common share and a special cash dividend of $0.075 per common share for the fourth quarter of 2023.

On Dec. 14, Seanergy announced that the Board of Directors of the Company (“BOD”) has authorized a new $25 million buyback program (the “Plan”) which can be utilized to repurchase the Company’s common shares and other securities. The Company will also fully repay its last remaining convertible note (the “Note”) pursuant to the terms of the Note. The Note bears a 5.5% coupon, it is the last from a series of convertible notes with aggregate original notional amount of $38.7 million and $3.2 million face value remains outstanding. The full repayment of the Note will preempt potential dilution upon conversion of the Note.

 
 

On Jan, 23, NAYA Biosciences Inc. (“NAYA”), a company which has recently signed a definitive merger agreement with INVO Bioscience (INVO, $.98) to establish an expanded, publicly-traded life science company dedicated to increasing patient access to breakthrough treatments in oncology, regenerative medicine, and fertility, today announced that it has entered into a binding letter of intent to acquire Florida Biotechnologies, Inc. a gene therapy company focusing on the treatment of mitochondrial diseases.announced that it has entered into a binding letter of intent to acquire Florida Biotechnologies, Inc. a gene therapy company focusing on the treatment of mitochondrial diseases. “We are delighted to contribute to the emergence of a strong biotech ecosystem leveraging Florida’s academic medical excellence,” commented Florida Biotechnologies cofounder Dr. Peter Kash. “The NAYA leadership team brings an agile entrepreneurial platform, broad development and commercialization experience, and access to public capital, which will unlock the potential of our promising AAV gene therapy platform for mitochondrial genetic diseases. As it expands its clinical pipeline to additional regenerative medicine as well as oncology and fertility programs, NAYA is poised to build a world-class Miami-based biopharmaceutical company.” “We are impressed by the initial safety and efficacy of the AAV gene therapy developed by Florida Biotechnologies and the University of Miami for the treatment of LHON, a rare and debilitating genetic disease with no currently approved therapeutic regimen,” commented NAYA Chairman & CEO Dr. Daniel Teper. “NAYA is committed to accelerating clinical development and Early Patient Access to this breakthrough therapy, which has the potential to achieve curative results in patients with progressive vision loss and blindness.”

On Jan 17, INVO Bioscience, announced that it has filed S-4 registration and preliminary joint proxy statements in connection with the upcoming merger. NAYA has also announced that five new board directors have joined its leadership team effective January 1st, 2024. The additions to the board join Chairman and Chief Executive Officer Dr. Daniel Teper, Vice Chairman Dr. Peter Kash, and Director Gilles Seydoux and will continue post-merger as part of the combined company alongside current INVO CEO Steve Shum. “NAYA is thrilled to welcome new board members with outstanding executive and entrepreneurial track records,” commented NAYA CEO Dr. Daniel Teper. “As we prepare for our merger with INVO, their experience will be key in helping the management team structure our group of companies and secure financing to advance our ambitious growth strategy for 2024 and beyond. Upon closing of the merger with INVO, the NAYA leadership team will focus on scaling up the fertility business through clinic acquisitions and revamped commercialization of INVOcell®, advancing the clinical development of our oncology assets, and building our regenerative medicine portfolio.”

On April 16 after the close, INVO Bioscience, Inc. (Nasdaq: INVO), a healthcare services fertility company focused on expanding access to advanced treatment worldwide through the establishment and acquisition of fertility clinics, and with the intravaginal culture (“IVC”) procedure enabled by its INVOcell® medical device, today announced financial results for the fourth quarter and fiscal year ended December 31, 2023 and provided a business update.

Q4 2023 Financial Highlights (all metrics compared to Q4 2022 unless otherwise noted)

Revenue was $1,381,754, an increase of 397% compared to $278,142.

Clinic revenue increased 519% to $1,362,938, compared to $220,253. All reported clinic revenue is derived from the Company’s INVO Center in Atlanta, Georgia, and fertility clinic in Madison, Wisconsin which are consolidated in the Company’s financial statements.

Revenue from all clinics, inclusive of both those accounted for as consolidated and under the equity method, was $1,634,912, an increase of 140% compared to $682,055.

Total operating expenses were $2.9 million, a $0.1 million decrease compared to $3.0 million. Included in the Q4 2023 operating expenses were approximately $250,000 pertaining to the definitive merger agreement with NAYA Biosciences, Inc. (“NAYA”) to acquire NAYA in an all-stock transaction.

Net loss was $(2.0) million compared to $(2.8) million.

Adjusted EBITDA (see table included) was $(1.2) million, including transaction costs related to the potential merger, compared to $(2.2) million in the prior year.



Thanks again for your attention this week. Please continue to share your thoughts, questions, & ideas as we move forward. 

In the meantime, please enjoy the balance of the weekly newsletter’s videos, quotes, updates and let’s find ways to crush it again as we move forward!

Investing & Inspiration

  1. “Nobody who ever gave his best regretted it.” – George Halas
  2. “Honest disagreement is often a good sign of progress.” – Mahatma Gandhi
  3. “A leader is one who knows the way, goes the way, and shows the way.” – John C. Maxwell
  4. “They always say time changes things, but you actually have to change them yourself.” – Andy Warhol
  5. “The secret of happiness is something to do.” – John Burroughs
  6. “The world of reality has its limits; the world of imagination is boundless.”
  7. “You begin with the possibilities of the material.” – Robert Rauschenberg
  8. “The only Zen you can find on the tops of mountains is the Zen you bring up there.” – Robert M. Pirsig
  9. “Leadership is the capacity to translate vision into reality.” – Warren Bennis
  10. “A man should always consider how much he has more than he wants.” – Joseph Addison
  11. “Happiness is good health and a bad memory.” –  Ingrid Bergman
  12. “We pass through this world but once.” – Stephen Jay Gould
  13. “Christmas waves a magic wand over this world, and behold, everything is softer and more beautiful.” – Norman Vincent Peale
  14. “Nothing can have value without being an object of utility.” – Karl Marx
  15. “Always turn a negative situation into a positive situation.” – Michael Jordan
  16. “Courage is found in unlikely places.” – J. R. R. Tolkien
  17. “One that would have the fruit must climb the tree.” – Thomas Fuller
  18. “Someone is sitting in the shade today because someone planted a tree a long time ago.” – Warren Buffett
  19. “We relish news of our heroes, forgetting that we are extraordinary to somebody too.” – Helen Hayes
  20. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” – George Bernard Shaw
  21. “Everything in the world may be endured except continual prosperity.”  – Johann Wolfgang von Goethe
  22. “Nine-tenths of wisdom is being wise in time.” – Theodore Roosevelt
  23. “Time is money.” – Benjamin Franklin
  24. “Change before you have to.” – Jack Welch
  25. “Our deeds determine us, as much as we determine our deeds.” – George Eliot
  26. “The Universe is under no obligation to make sense to you.” – Neil deGrasse Tyson
  27. “Care and diligence bring luck.” – Thomas Fuller
  28. “Nobody made a greater mistake than he who did nothing because he could do only a little.” – Edmund Burke
  29. “A man who is a master of patience is master of everything else.” – George Savile
  30. “Once you replace negative thoughts with positive ones, you’ll start having positive results.” – Willie Nelson
  31. “Endurance is nobler than strength, and patience than beauty.” – John Ruskin
  32. “Act as if what you do makes a difference. It does.” – William James
  33. “Let us be grateful to people who make us happy, they are the charming gardeners who make our souls blossom.” –  Marcel Proust
  34. “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill
  35. “Science may never come up with a better office communication system than the coffee break.” – Earl Wilson
  36. “If everyone is moving forward together, then success takes care of itself.” – Henry Ford
  37. “Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.”– Samuel Smiles
  38. “Patriotism is supporting your country all the time, and your government when it deserves it.” – Mark Twain
  39. “What would life be if we had no courage to attempt anything?” – Vincent Van Gogh
  40. “The biggest risk is not taking any risk… In a world that is changing really quickly, the only strategy that is guaranteed to fail is not taking risks.” – Mark Zuckerberg
  41. “Our lives improve only when we take chances – and the first and most difficult risk we can take is to be honest with ourselves.” – Walter Anderson
  42. “Action is the foundational key to all success.” – Pablo Picasso
  43. “Success is never final, failure is never fatal. It’s courage that counts.” – John Wooden
  44. “Innovation distinguishes between a leader and a follower.” – Steve Jobs
  45. “All the art of living lies in a fine mingling of letting go and holding on.” – Havelock Ellis
  46. “The size of your success is measured by the strength of your desire; the size of your dream; and how you handle disappointment along the way.” – Robert Kiyosaki
  47. “O, wind, if winter comes, can spring be far behind?” – Percy Bysshe Shelley
  48. “Patience is a virtue, and I’m learning patience. It’s a tough lesson.” – Elon Musk
  49. “Be true to your work, your word, and your friend.” – John Boyle O’Reilly
  50. “Believe in yourself! Have faith in your abilities! Without a humble but reasonable confidence in your own powers you cannot be successful or happy.” – Norman Vincent Peale
  51. “Surprise is the greatest gift which life can grant us.” – Boris Pasternak
  52. “Logic will get you from A to B. Imagination will take you everywhere.” – Albert Einstein
  53. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  54. “Do exactly what you would do if you felt most secure.” – Meister Eckhart
  55. “Life lived for tomorrow will always be just a day away from being realized.” – Leo Buscaglia
  56. “Wisdom is oftentimes nearer when we stoop than when we soar.” – Wordsworth
  57. “Take chances, make mistakes. That’s how you grow. Pain nourishes your courage. You have to fail in order to practice being brave.” – Mary Tyler Moore
  58. “A single twig breaks, but the bundle of twigs is strong.” – Tecumseh
  59. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  60. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  61. “The limits of the possible can only be defined by going beyond them into the impossible.” – Arthur C. Clarke
  62. “Be faithful in small things because it is in them that your strength lies.” – Mother Teresa
  63. “The future rewards those who press on. I don’t have time to feel sorry for myself. I don’t have time to complain. I’m going to press on.” – Barack Obama
  64. “By three methods we may learn wisdom: First, by reflection, which is noblest; Second, by imitation, which is easiest; and third by experience, which is the bitterest.” – Confucius
  65. “No man was ever wise by chance.” – Lucius Annaeus Seneca
  66. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  67. “It is not in the stars to hold our destiny but in ourselves.” – William Shakespeare
  68. “It does not matter how slowly you go as long as you do not stop.” – Confucius

  69. “I want to put a ding in the universe.” – Steve Jobs

  70. “Research is creating new knowledge.” – Neil Armstrong

  71. “The reward for work well done is the opportunity to do more.” – Jonas Salk
  72. “Man is a creative retrospection of nature upon itself.” – Karl Wilhelm Friedrich Schlegel
  73. “There’s something about taking a plow and breaking new ground. It gives you energy.” – Ken Kesey
  74. “Success seems to be largely a matter of hanging on after others have let go.” – William Feather

  75. “The essential conditions of everything you do must be choice, love, passion.” – Nadia Boulanger
  76. “More business is lost every year through neglect than through any other cause.” – Rose Kennedy

  77. “Give me a lever long enough and a fulcrum on which to place it, and I shall move the world.” – Archimedes

  78. “A person who won’t read has no advantage over one who can’t read.” – Mark Twain
  79. “The best way out is always through.” – Robert Frost

  80. “Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” – Francis of Assisi
  81. “Without labor nothing prospers.” – Sophocles

  82. “Intellectuals solve problems, geniuses prevent them.” – Albert Einstein
  83. “This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.” – Hannah Arendt

  84. “The best and most beautiful things in the world cannot be seen or even touched – they must be felt with the heart.” – Helen Keller

  85. “He who is brave is free.” – Lucius Annaeus Seneca
  86. “When something is important enough, you do it even if the odds are not in your favor.” – Elon Musk

  87. “I choose a block of marble and chop off whatever I don’t need.” – Auguste Rodin

  88. “Hope is the only bee that makes honey without flowers.” – Robert Green Ingersoll

  89. “He who knows that enough is enough will always have enough.” – Lao Tzu

  90. “Plans to protect air and water, wilderness and wildlife are in fact plans to protect man.” – Stewart Udall
  91. “In order to carry a positive action we must develop here a positive vision.” – Dalai Lama

  92. “A hero is someone who understands the responsibility that comes with his freedom.” – Bob Dylan
  93. “Inflation destroys savings, impedes planning, and discourages investment. That means less productivity and a lower standard of living.” – Kevin Brady
  94. “If we give something positive to others, it will return to us. If we give negative, that negativity will be returned.” – Allu Arjun
  95. “A good plan violently executed now is better than a perfect plan executed next week.” ~ George S. Patton
  96. “You must do the things you think you cannot do.”- Eleanor Roosevelt
  97. “Success is dependent on effort.” – Sophocles
  98. “Nobody who ever gave his best regretted it.” – George Halas
  99. “Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down.” ~ Oprah Winfrey
  100. “And when I breathed, my breath was lightning.” – Black Elk
  101. “Moderation is the silken string running through the pearl chain of all virtues.” – Joseph Hall
  102. “You are the sum total of everything you’ve ever seen, heard, eaten, smelled, been told, forgot – it’s all there. Everything influences each of us, and because of that I try to make sure that my experiences are positive.” – Maya Angelou
  103. “If you want a guarantee, buy a toaster.” – Clint Eastwood
  104. “We are an impossibility in an impossible universe.” – Ray Bradbury
  105. “If you think in terms of a year, plant a seed; if in terms of ten years, plant trees; if in terms of 100 years, teach the people.” – Confucius
  106. “I’d rather attempt to do something great and fail than to attempt to do nothing and succeed.” – Robert H. Schuller
  107. Do your little bit of good where you are; it’s those little bits of good put together that overwhelm the world.” Desmond Tutu
  108. “It takes considerable knowledge just to realize the extent of your own ignorance.” – Thomas Sowell
  109. “Do not dwell in the past, do not dream of the future, concentrate the mind on the present moment.” – Buddha”
  110. Surprise is the greatest gift which life can grant us.” –  Boris Pasternak
  111. “Trust in dreams, for in them is hidden the gate to eternity.” – Khalil Gibran 
  112. “Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.” – Bruce Lee
  113. “All life is an experiment. The more experiments you make the better.” – Ralph Waldo Emerson
  114. “There are no secrets to success. It is the result of preparation, hard work, and learning from failure.” –  Colin Powell
  115. “There is more to life than increasing its speed.” – Mahatma Gandhi
  116. “Your attitude is like a box of crayons that color your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.” – Allen Klein
  117. “Definiteness of purpose is the starting point of all achievement.” – W. Clement Stone
  118. “Success usually comes to those who are too busy to be looking for it.” – Henry David Thoreau
  119. “In matters of truth and justice, there is no difference between large and small problems, for issues concerning the treatment of people are all the same.” – Albert Einstein
  120. “Life is too short for long-term grudges.” – Elon Musk
  121. There cannot be a crisis next week. My schedule is already full.” – Henry Kissinger
  122. “Success consists of getting up just one more time than you fall.” – Oliver Goldsmith
  123. “The Earth is the cradle of humanity, but mankind cannot stay in the cradle forever.” – Konstantin Tsiolkovsky
  124. “Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living.” – Omar N. Bradley
  125. “Beauty surrounds us, but usually we need to be walking in a garden to know it.” – Rumi
  126. “But man is not made for defeat. A man can be destroyed but not defeated.” – Ernest Hemingway
  127. “Don’t watch the clock; do what it does. Keep going.” – Sam Levenson
  128. “Let there be work, bread, water and salt for all.” – Nelson Mandela
  129. “The social object of skilled investment should be to defeat the dark forces of time and ignorance which envelope our future.” – John Maynard Keynes
  130. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  131. “I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones.” – Albert Einstein
  132. “It is the fight alone that pleases us, not the victory.” – Blaise Pascal
  133. “If you can’t describe what you are doing as a process, you don’t know what you’re doing.” – W. Edwards Deming
  134. “Never interrupt your enemy when he is making a mistake.” – Napoleon Bonaparte
  135. “Be sure you put your feet in the right place, then stand firm.” – Abraham Lincoln
  136. “Without investment there will not be growth, and without growth there will not be employment.” – Muhtar Kent
  137. “You have to do your own growing no matter how tall your grandfather was.” – Abraham Lincoln
  138. “Victory has a thousand fathers, but defeat is an orphan.” – John F. Kennedy
  139. “Delete the negative; accentuate the positive!” – Donna Karan
  140. “It’s crazy how fast time flies and how things progress.” – Nathan Chen
  141. “The world is a dangerous place to live; not because of the people who are evil, but because of the people who don’t do anything about it.” – Albert Einstein
  142. “Life isn’t about finding yourself. Life is about creating yourself.” – George Bernard Shaw
  143. “Everything has beauty, but not everyone sees it.” – Confucius
  144. A man must be big enough to admit his mistakes, smart enough to profit from them, and strong enough to correct them.” – John C. Maxwell
  145. “Walking with a friend in the dark is better than walking alone in the light.” – Helen Keller
  146. “A man who dares to waste one hour of time has not discovered the value of life.” – Charles Darwin
  147. “The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark.” – Michelangelo
  148. “Progress is man’s ability to complicate simplicity.” – Thor Heyerdahl
  149. “I like to encourage people to realize that any action is a good action if it’s proactive and there is positive intent behind it.” – Michael J. Fox
  150. “Nothing is impossible, the word itself says ‘I’m possible’!” – Audrey Hepburn
  151. “But investment in space stimulates society, it stimulates it economically, it stimulates it intellectually, and it gives us all passion.” – Bill Nye
  152. “Bitcoin, in the short or even long term, may turn out be a good investment in the same way that anything that is rare can be considered valuable. Like baseball cards. Or a Picasso.” – Andrew Ross Sorkin
  153. “Life is a tragedy when seen in close-up, but a comedy in long-shot.” – Charlie Chaplin
  154. “No matter what you’re going through, there’s a light at the end of the tunnel and it may seem hard to get to it but you can do it and just keep working towards it and you’ll find the positive side of things.” – Demi Lovato
  155. “Infrastructure investment in science is an investment in jobs, in health, in economic growth and environmental solutions.” – Oren Etzioni
  156. “Educating our children and giving them the skills they need to compete in a global economy is a smart investment in our country’s future.” – Sheldon Whitehouse
  157. “Know thy self, know thy enemy. A thousand battles, a thousand victories.” – Sun Tzu
  158. “If one does not know to which port one is sailing, no wind is favorable.” – Lucius Annaeus Seneca
  159. “Beware of missing chances; otherwise it may be altogether too late some day.” – Franz Liszt
  160. “The sofa is a really important investment for anybody, and I don’t mean financially. You need to find a really great sofa that can transition with you, and you can build from there.” – Jeremiah Brent
  161. “There is no investment you can make which will pay you so well as the effort to scatter sunshine and good cheer through your establishment.” – Orison Swett Marden
  162. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” – Marie Curie
  163. “There is little that can withstand a man who can conquer himself.” – Louis XIV
  164. “In tennis, you strike a ball just after the rebound for the fastest return. It’s the same with investment.” – Masayoshi Son
  165. “A camel makes an elephant feel like a jet plane.” – Jackie Kennedy
  166. “The advance of technology is based on making it fit in so that you don’t really even notice it, so it’s part of everyday life.” – Bill Gates
  167. “Success depends upon previous preparation, and without such preparation there is sure to be failure.” – Confucius, Chinese 
  168. “Coming together is a beginning; keeping together is progress; working together is success.” – Edward Everett Hale
  169. “Never do anything against conscience even if the state demands it.”– Albert Einstein
  170. “Education is not only a ladder of opportunity, but it is also an investment in our future.” – Ed Markey
  171. “The true measure of a man is how he treats someone who can do him absolutely no good.” – Samuel Johnson
  172. “In my view, the biggest investment risk is not the volatility of prices, but whether you will suffer a permanent loss of capital. Not only is the mere drop in stock prices not risk, but it is an opportunity. Where else do you look for cheap stocks?” – Li Lu
  173. “A successful society is characterized by a rising living standard for its population, increasing investment in factories and basic infrastructure, and the generation of additional surplus, which is invested in generating new discoveries in science and technology.” – Robert Trout
  174. “The best preparation for tomorrow is doing your best today.” – H. Jackson Brown, Jr.
  175. “Friendship marks a life even more deeply than love. Love risks degenerating into obsession, friendship is never anything but sharing.” – Elie Wiesel
  176. “Investing in women’s lives is an investment in sustainable development, in human rights, in future generations – and consequently in our own long-term national interests.” – Liya Kebede
  177. “Success isn’t measured by money or power or social rank. Success is measured by your discipline and inner peace.” – Mike Ditka
  178. “No matter how many goals you have achieved, you must set your sights on a higher one.” – Jessica Savitch 
  179. “Start where you are. Use what you have. Do what you can.”– Arthur Ashe
  180. “The secret of getting ahead is getting started.” – Mark Twain
  181. “The amount of work and the amount of both physical and emotional investment it takes to get to the top.” – Drew Bledsoe

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