company profile
Lantern Pharma (NASDAQ: LTRN) is an artificial intelligence (“AI”) company developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning (“ML”) platform with multiple clinical stage drug programs focused on innovating the cancer drug development process by using advanced genomics, machine learning, and artificial intelligence (“A.I.”).
Their A.I. platform, known as RADR®️, currently includes more than 25 billion data points, and uses big data analytics and machine learning to rapidly uncover biologically relevant genomic signatures correlated to drug response, and then to identify the cancer patients that they believe may benefit most from their compounds. RADR®️ is also used by Lantern and its collaborators to 1) develop and position new drugs and 2) to rescue and reposition drug candidates that others have tried, but failed, to develop.
Lantern’s current portfolio consists of four drug candidates and an ADC program across eleven disclosed tumor targets, including two Phase 2 programs and several additional Phase 1 clinical trials anticipated for 2023. Lantern seeks out experienced industry partners, world-class scientific advisors and innovative clinical-regulatory approaches to assist with its objective of delivering cancer therapies to patients as quickly and cost-effectively as possible. This data-driven, genomically-targeted and biomarker-driven approach allows us to pursue a transformational drug development strategy that identifies, rescues or develops, and advances potential small molecule drug candidates at what we believe is a fraction of the time and cost associated with traditional cancer drug development.
vista's key points
- Lantern is an artificial intelligence ("AI") company developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning ("ML") platform with multiple clinical stage drug programs.
- Lantern believes that the use of machine learning, genomics and computational methods can help accelerate the development and commercialization of small molecule-based therapies. These drugs can be targeted to patients whose genomic profile identifies them as having the highest probability of benefiting from the drug, thereby creating the potential to achieve better outcomes.
- Their proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development.
- By harnessing the power of AI and with input from world-class scientific advisors and collaborators, they have accelerated the development of their growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program.
- On average, their newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.
- Lantern’s current portfolio consists of four drug candidates and an ADC program across 12 cancer indications, including two phase 2 programs.
- Lantern has been granted multiple Orphan Drug Designations by the FDA for LP-184 in pancreatic cancer, malignant gliomas, and atypical teratoid rhabdoid tumors (ATRT); in addition the FDA granted Rare Pediatric Disease Designation granted for LP-184 in ATRT.
- The cancer indications being pursued for LP-184 are estimated to have an annual market potential of $11-13 billion; $6-7 billion for solid tumors and $5-6 billion for brain and CNS cancers.
- Lantern will leverage its proprietary AI platform, RADR®, to rapidly develop novel cryptophycin-antibody drug conjugates (ADCs), which represent an exciting class of potent and highly targeted drug candidates.
- The global ADC market is currently over $4.0 billion and is projected to reach $14.0 billion by 2027.
- Lantern is receiving an exclusive and worldwide option to license intellectual property from Bielefeld University related to the collaboration and IP generated from the collaboration.
- The Harmonic™ trial (NCT05456256) is a Phase 2 clinical trial that is assessing the effect of Lantern's investigational new drug LP-300 in combination with standard-of-care (SOC) chemotherapy, pemetrexed and carboplatin, on the overall and progression-free survival of never smoker patients with advanced non-small cell lung cancer (NSCLC).
- $51.5 million in cash, cash equivalents, and marketable securities as of March 31, 2023 and management has stated that Lantern has a cash runway into 2025.
VISTA'S PROGRESS REPORT
Lantern Pharma is led Panna Sharma (pictured above) is the President, CEO, and Board Member of Lantern Pharma Inc., a clinical-stage oncology biotech using artificial intelligence (AI) and genomics to innovate the rescue, revitalization, and development of precision cancer therapeutics. Lantern is focused on improving patient outcomes by using its proprietary AI platform – Response Algorithm for Drug Repositioning & Rescue (RADR®) – to rescue, revitalize and develop abandoned or failed cancer drugs, and to accelerate their development through precision trials that help identify patient groups more likely to respond to its pipeline of targeted cancer therapies.
As Chief Executive Officer, Panna is responsible for developing Lantern’s strategic vision, and working closely with the venture investors to raise capital that will place the Company at the forefront of using AI and genomics in developing its pipeline of precision therapies. The Lantern Pharma (LP) pipeline currently consists of four drug candidates and an ADC program across 8 tumor targets, including two phase 2 programs, all focusing on cancers that have unique and unmet clinical needs with a clearly defined patient population. These drugs can be targeted to patients whose profile identifies them as having the highest probability of benefiting from the drug, thereby achieving better outcomes with reduced costs and accelerated timelines.
Prior to joining Lantern in 2018, Panna was the President and Chief Executive Officer of Cancer Genetics, Inc. (Nasdaq: CGIX), a provider of genomic and immune-based cancer diagnostics and therapy development services to some of the most prestigious medical institutions and pharma companies in the world. In his capacity as CEO at CGIX, he raised over $100 million in the public and private markets and grew the company from 25 employees in New Jersey to over 250 employees globally across multiple continents. Panna took CGIX public in 2013 and acquired four companies globally that help CGIX deliver on its mission to help personalize cancer treatment. Prior to CGIX, Panna founded TSG Partners, a specialty advisory group combining corporate strategy and corporate finance to create shareholder value for companies and investors in the life sciences, biotechnology, and environmental sciences. Panna began his career as an industry analyst for financial services and technology companies and was part of the management team that took the digital strategy and e-business company iXL public.
Panna attended Boston University in the University Professors Program and focused his studies on Philosophy of Science, Neural Networks and Artificial Intelligence. When not focused on the future of biotech, machine learning, emerging technologies, and genomics, Panna can be found with his three children and wife and listening to music, attending sports functions, discussing new and ethical uses of A.I., debating language theories and enjoying the vibrant and evolving local food scene.
vista's key points
- Lantern is an artificial intelligence ("AI") company developing targeted and transformative cancer therapies using its proprietary RADR® AI and machine learning ("ML") platform with multiple clinical stage drug programs.
- Lantern believes that the use of machine learning, genomics and computational methods can help accelerate the development and commercialization of small molecule-based therapies. These drugs can be targeted to patients whose genomic profile identifies them as having the highest probability of benefiting from the drug, thereby creating the potential to achieve better outcomes.
- Their proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development.
- By harnessing the power of AI and with input from world-class scientific advisors and collaborators, they have accelerated the development of their growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program.
- On average, their newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.
- Lantern’s current portfolio consists of four drug candidates and an ADC program across 12 cancer indications, including two phase 2 programs.
- Lantern has been granted multiple Orphan Drug Designations by the FDA for LP-184 in pancreatic cancer, malignant gliomas, and atypical teratoid rhabdoid tumors (ATRT); in addition the FDA granted Rare Pediatric Disease Designation granted for LP-184 in ATRT.
- The cancer indications being pursued for LP-184 are estimated to have an annual market potential of $11-13 billion; $6-7 billion for solid tumors and $5-6 billion for brain and CNS cancers.
- Lantern will leverage its proprietary AI platform, RADR®, to rapidly develop novel cryptophycin-antibody drug conjugates (ADCs), which represent an exciting class of potent and highly targeted drug candidates.
- The global ADC market is currently over $4.0 billion and is projected to reach $14.0 billion by 2027.
- Lantern is receiving an exclusive and worldwide option to license intellectual property from Bielefeld University related to the collaboration and IP generated from the collaboration.
- The Harmonic™ trial (NCT05456256) is a Phase 2 clinical trial that is assessing the effect of Lantern's investigational new drug LP-300 in combination with standard-of-care (SOC) chemotherapy, pemetrexed and carboplatin, on the overall and progression-free survival of never smoker patients with advanced non-small cell lung cancer (NSCLC).
- $51.5 million in cash, cash equivalents, and marketable securities as of March 31, 2023 and management has stated that Lantern has a cash runway into 2025.
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