Merck & Co., Inc. (MRK) is a global healthcare solutions provider that has been working towards bringing forward medicine and vaccines for some of the world’s most challenging diseases for more than a century. They are committed to increasing health care access and continue to be at the leading edge of research. Merck has the industry’s largest immuno-oncology clinical research program
Merck has entered into a collective agreement through a subsidiary of Seattle Genetics, Inc. (SGEN) and Astellas Pharma Inc to evaluate the efficacy and combination of Seattle Genetics’ and Astellas’ antibody-drug conjugate enfortumab vedotin and Merck’s anti-PD-1 therapy, KEYTRUDA® in patients with untreated metastatic urothelial cancer previously.
“We look forward to initiating a randomized phase 3 trial in patients with previously untreated locally advanced or metastatic urothelial cancer. Recent data from a phase 1b trial of enfortumab vedotin in combination with pembrolizumab showed evidence of clinical activity leading to the development of this phase 3 trial” stated Roger Dansey, M.D., Chief Medical Officer at Seattle Genetics.
Andrew Krivoshik, M.D., Ph.D., Senior Vice President and Oncology Therapeutic Area Head at Astellas stated, “An unmet medical need exists for previously untreated patients with metastatic urothelial cancer, and we are committed to studying enfortumab vedotin in combination with other agents in different stages of urothelial cancer. We look forward to further evaluating enfortumab vedotin and pembrolizumab in this high unmet need patient population.”
Urothelial cancer is the most common type of bladder cancer. Last Year globally, approximately 549k people were diagnosed with bladder cancer reporting 200k deaths worldwide.
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