Reportedly, an experimental Amgen Inc (AMGN) drug meant for a specific genetic mutation reduced tumors in 32% of advanced lung cancer patients and 7% with those suffering from colon cancer in an early-stage trial. The drug sotorasib was given to lung cancer patients for 6.3 months and 4 months for colorectal cancer patients before their disease worsened. The oral dose of medication is formulated to target a mutated form of a gene known as KRAS, occurring in about 13% of the most common form of lung cancer, the non-small cell lung cancers (NSCLC). The above mutation is also found in 1% to 3% of colorectal and other cancers. Sotorasib targets gene mutations leading to cancer, irrespective of which organ the disease originated.
As per the research and dosage, among the 59 patients, 32% had a partial reaction to the drug, with tumor reduction by at least 30%, and the remaining percentage experienced slow response or stable disease. 42 patients with colorectal cancer experienced 7% had tumor reduction, and 74% had stable disease.
Gregory Friberg, Amgen’s head of oncology global development stated, “These are patients that have very few options. They were on a third or fourth line of therapy.”
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