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Amgen’s Experimental Drug Shows Sign Of Improvement In Lung Cancer Patients With KRAS Gene Mutation

By John F. Heerdink, Jr.

Reportedly, an experimental Amgen Inc (AMGN) drug meant for a specific genetic mutation reduced tumors in 32% of advanced lung cancer patients and 7% with those suffering from colon cancer in an early-stage trial. The drug sotorasib was given to lung cancer patients for 6.3 months and 4 months for colorectal cancer patients before their disease worsened. The oral dose of medication is formulated to target a mutated form of a gene known as KRAS, occurring in about 13% of the most common form of lung cancer, the non-small cell lung cancers (NSCLC). The above mutation is also found in 1% to 3% of colorectal and other cancers. Sotorasib targets gene mutations leading to cancer, irrespective of which organ the disease originated.

As per the research and dosage, among the 59 patients, 32% had a partial reaction to the drug, with tumor reduction by at least 30%, and the remaining percentage experienced slow response or stable disease. 42 patients with colorectal cancer experienced 7% had tumor reduction, and 74% had stable disease.

Gregory Friberg, Amgen’s head of oncology global development stated, “These are patients that have very few options. They were on a third or fourth line of therapy.”


Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

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(Read Original Story: Amgen drug shrinks tumors in lung cancer patients with KRAS gene mutation -study in Reuters)


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